Set-up of a method using LC-UV to assay mometasone furoate in pharmaceutical dosage forms

Detalhes bibliográficos
Autor(a) principal: Ourique, Aline Ferreira
Data de Publicação: 2012
Outros Autores: Contri, Renata Vidor, Guterres, Silvia Stanisçuaski, Beck, Ruy Carlos Ruver, Pohlmann, Adriana Raffin, Melero, Ana Z., Schaefer, Ulrich F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/72884
Resumo: A reliable method using LC-UV to assay mometasone furoate (MF) in creams or nasal sprays using the same chromatographic conditions was set up. Methanol:water 80:20 (v/v) (1.0 mL min-1) was used as mobile phase. MF was detected at 248 nm and analyzed in a concentration range from 1.0 to 20.0 μg mL-1. The method provided acceptable theoretical plates, peak simmetry, peak tailing factor and peak resolution a short run (5 min). The method showed specificity, good linearity (r = 0.9999) and the quantification limit was 0.379 μg mL-1. Furthermore, the method was precise (RSD < 2.0%), accurate (recovery > 97%) and robust.
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spelling Ourique, Aline FerreiraContri, Renata VidorGuterres, Silvia StanisçuaskiBeck, Ruy Carlos RuverPohlmann, Adriana RaffinMelero, Ana Z.Schaefer, Ulrich F.2013-07-02T01:43:21Z20120100-4042http://hdl.handle.net/10183/72884000837761A reliable method using LC-UV to assay mometasone furoate (MF) in creams or nasal sprays using the same chromatographic conditions was set up. Methanol:water 80:20 (v/v) (1.0 mL min-1) was used as mobile phase. MF was detected at 248 nm and analyzed in a concentration range from 1.0 to 20.0 μg mL-1. The method provided acceptable theoretical plates, peak simmetry, peak tailing factor and peak resolution a short run (5 min). The method showed specificity, good linearity (r = 0.9999) and the quantification limit was 0.379 μg mL-1. Furthermore, the method was precise (RSD < 2.0%), accurate (recovery > 97%) and robust.application/pdfengQuímica nova. São Paulo. Vol. 35, n. 4, (2012), p. 818-821Produtos farmacêuticosCromatografia liquidaMometasonaPharmaceuticalsLiquid chromatographyMometasoneSet-up of a method using LC-UV to assay mometasone furoate in pharmaceutical dosage formsinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000837761.pdf000837761.pdfTexto completo (inglês)application/pdf262272http://www.lume.ufrgs.br/bitstream/10183/72884/1/000837761.pdfcd01cd041309663b5c4e1fee96bed99bMD51TEXT000837761.pdf.txt000837761.pdf.txtExtracted Texttext/plain20514http://www.lume.ufrgs.br/bitstream/10183/72884/2/000837761.pdf.txtdbd82406b415c18806163734c9515613MD52THUMBNAIL000837761.pdf.jpg000837761.pdf.jpgGenerated Thumbnailimage/jpeg1901http://www.lume.ufrgs.br/bitstream/10183/72884/3/000837761.pdf.jpg11464d01968f8245b34403631b7fb159MD5310183/728842020-02-20 04:16:04.216478oai:www.lume.ufrgs.br:10183/72884Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2020-02-20T07:16:04Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Set-up of a method using LC-UV to assay mometasone furoate in pharmaceutical dosage forms
title Set-up of a method using LC-UV to assay mometasone furoate in pharmaceutical dosage forms
spellingShingle Set-up of a method using LC-UV to assay mometasone furoate in pharmaceutical dosage forms
Ourique, Aline Ferreira
Produtos farmacêuticos
Cromatografia liquida
Mometasona
Pharmaceuticals
Liquid chromatography
Mometasone
title_short Set-up of a method using LC-UV to assay mometasone furoate in pharmaceutical dosage forms
title_full Set-up of a method using LC-UV to assay mometasone furoate in pharmaceutical dosage forms
title_fullStr Set-up of a method using LC-UV to assay mometasone furoate in pharmaceutical dosage forms
title_full_unstemmed Set-up of a method using LC-UV to assay mometasone furoate in pharmaceutical dosage forms
title_sort Set-up of a method using LC-UV to assay mometasone furoate in pharmaceutical dosage forms
author Ourique, Aline Ferreira
author_facet Ourique, Aline Ferreira
Contri, Renata Vidor
Guterres, Silvia Stanisçuaski
Beck, Ruy Carlos Ruver
Pohlmann, Adriana Raffin
Melero, Ana Z.
Schaefer, Ulrich F.
author_role author
author2 Contri, Renata Vidor
Guterres, Silvia Stanisçuaski
Beck, Ruy Carlos Ruver
Pohlmann, Adriana Raffin
Melero, Ana Z.
Schaefer, Ulrich F.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ourique, Aline Ferreira
Contri, Renata Vidor
Guterres, Silvia Stanisçuaski
Beck, Ruy Carlos Ruver
Pohlmann, Adriana Raffin
Melero, Ana Z.
Schaefer, Ulrich F.
dc.subject.por.fl_str_mv Produtos farmacêuticos
Cromatografia liquida
Mometasona
topic Produtos farmacêuticos
Cromatografia liquida
Mometasona
Pharmaceuticals
Liquid chromatography
Mometasone
dc.subject.eng.fl_str_mv Pharmaceuticals
Liquid chromatography
Mometasone
description A reliable method using LC-UV to assay mometasone furoate (MF) in creams or nasal sprays using the same chromatographic conditions was set up. Methanol:water 80:20 (v/v) (1.0 mL min-1) was used as mobile phase. MF was detected at 248 nm and analyzed in a concentration range from 1.0 to 20.0 μg mL-1. The method provided acceptable theoretical plates, peak simmetry, peak tailing factor and peak resolution a short run (5 min). The method showed specificity, good linearity (r = 0.9999) and the quantification limit was 0.379 μg mL-1. Furthermore, the method was precise (RSD < 2.0%), accurate (recovery > 97%) and robust.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2013-07-02T01:43:21Z
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/72884
dc.identifier.issn.pt_BR.fl_str_mv 0100-4042
dc.identifier.nrb.pt_BR.fl_str_mv 000837761
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dc.language.iso.fl_str_mv eng
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dc.relation.ispartof.pt_BR.fl_str_mv Química nova. São Paulo. Vol. 35, n. 4, (2012), p. 818-821
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