Sensitive method for determination of piplartine, an alkaloid amide from Piper species, in rat plasma samples by liquid chromatography-tandem mass spectrometry

Detalhes bibliográficos
Autor(a) principal: Bezerra,Daniel P.
Data de Publicação: 2012
Outros Autores: Pessoa,Cláudia, Moraes,Manoel O., Costa-Lotufo,Letícia V., Rubio Gouvea,Dayana, Jabor,Valquíria A. Polisel, Lopes,Norberto Peporine, Borges,Keyller Bastos, Lima,Mary Anne S., Silveira,Edilberto R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000300004
Resumo: Piplartine (PPTN) is an alkaloid amide found in Piper species that presents different activities. PPTN determination in rat plasma is necessary to better understand its biological effects. The aim of this study was to develop a sensitive LC-MS/MS method for the determination of PPTN in rat plasma. The performance criteria for linearity, sensitivity, precision, accuracy, recovery, and stability have been assessed and were within the recommended guidelines. The validated method proved to be suitable in a pilot study of PPTN kinetic disposition in rat plasma after a single intraperitoneal dose, and represents an appropriate tool to further pharmacokinetic studies.
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spelling Sensitive method for determination of piplartine, an alkaloid amide from Piper species, in rat plasma samples by liquid chromatography-tandem mass spectrometrypiplartineLC-MS/MSrat plasma analysisPiplartine (PPTN) is an alkaloid amide found in Piper species that presents different activities. PPTN determination in rat plasma is necessary to better understand its biological effects. The aim of this study was to develop a sensitive LC-MS/MS method for the determination of PPTN in rat plasma. The performance criteria for linearity, sensitivity, precision, accuracy, recovery, and stability have been assessed and were within the recommended guidelines. The validated method proved to be suitable in a pilot study of PPTN kinetic disposition in rat plasma after a single intraperitoneal dose, and represents an appropriate tool to further pharmacokinetic studies.Sociedade Brasileira de Química2012-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000300004Química Nova v.35 n.3 2012reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422012000300004info:eu-repo/semantics/openAccessBezerra,Daniel P.Pessoa,CláudiaMoraes,Manoel O.Costa-Lotufo,Letícia V.Rubio Gouvea,DayanaJabor,Valquíria A. PoliselLopes,Norberto PeporineBorges,Keyller BastosLima,Mary Anne S.Silveira,Edilberto R.eng2012-04-24T00:00:00Zoai:scielo:S0100-40422012000300004Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2012-04-24T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Sensitive method for determination of piplartine, an alkaloid amide from Piper species, in rat plasma samples by liquid chromatography-tandem mass spectrometry
title Sensitive method for determination of piplartine, an alkaloid amide from Piper species, in rat plasma samples by liquid chromatography-tandem mass spectrometry
spellingShingle Sensitive method for determination of piplartine, an alkaloid amide from Piper species, in rat plasma samples by liquid chromatography-tandem mass spectrometry
Bezerra,Daniel P.
piplartine
LC-MS/MS
rat plasma analysis
title_short Sensitive method for determination of piplartine, an alkaloid amide from Piper species, in rat plasma samples by liquid chromatography-tandem mass spectrometry
title_full Sensitive method for determination of piplartine, an alkaloid amide from Piper species, in rat plasma samples by liquid chromatography-tandem mass spectrometry
title_fullStr Sensitive method for determination of piplartine, an alkaloid amide from Piper species, in rat plasma samples by liquid chromatography-tandem mass spectrometry
title_full_unstemmed Sensitive method for determination of piplartine, an alkaloid amide from Piper species, in rat plasma samples by liquid chromatography-tandem mass spectrometry
title_sort Sensitive method for determination of piplartine, an alkaloid amide from Piper species, in rat plasma samples by liquid chromatography-tandem mass spectrometry
author Bezerra,Daniel P.
author_facet Bezerra,Daniel P.
Pessoa,Cláudia
Moraes,Manoel O.
Costa-Lotufo,Letícia V.
Rubio Gouvea,Dayana
Jabor,Valquíria A. Polisel
Lopes,Norberto Peporine
Borges,Keyller Bastos
Lima,Mary Anne S.
Silveira,Edilberto R.
author_role author
author2 Pessoa,Cláudia
Moraes,Manoel O.
Costa-Lotufo,Letícia V.
Rubio Gouvea,Dayana
Jabor,Valquíria A. Polisel
Lopes,Norberto Peporine
Borges,Keyller Bastos
Lima,Mary Anne S.
Silveira,Edilberto R.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bezerra,Daniel P.
Pessoa,Cláudia
Moraes,Manoel O.
Costa-Lotufo,Letícia V.
Rubio Gouvea,Dayana
Jabor,Valquíria A. Polisel
Lopes,Norberto Peporine
Borges,Keyller Bastos
Lima,Mary Anne S.
Silveira,Edilberto R.
dc.subject.por.fl_str_mv piplartine
LC-MS/MS
rat plasma analysis
topic piplartine
LC-MS/MS
rat plasma analysis
description Piplartine (PPTN) is an alkaloid amide found in Piper species that presents different activities. PPTN determination in rat plasma is necessary to better understand its biological effects. The aim of this study was to develop a sensitive LC-MS/MS method for the determination of PPTN in rat plasma. The performance criteria for linearity, sensitivity, precision, accuracy, recovery, and stability have been assessed and were within the recommended guidelines. The validated method proved to be suitable in a pilot study of PPTN kinetic disposition in rat plasma after a single intraperitoneal dose, and represents an appropriate tool to further pharmacokinetic studies.
publishDate 2012
dc.date.none.fl_str_mv 2012-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000300004
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000300004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422012000300004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.35 n.3 2012
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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