Simultaneous spectrophotometric determination of lamivudine and zidovudine in fixed dose combinations using multivariate calibration

Detalhes bibliográficos
Autor(a) principal: Grangeiro Jr.,Severino
Data de Publicação: 2011
Outros Autores: Albuquerque,Miracy M., Santana,Davi P., Pimentel,Maria Fernanda, Silva,Reniere H. da, Simões,Simone S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000500022
Resumo: The simultaneous determination of two or more active components in pharmaceutical preparations, without previous chemical separation, is a common analytical problem. Published works describe the determination of AZT and 3TC separately, as raw material or in different pharmaceutical preparations. In this work, a method using UV spectroscopy and multivariate calibration is described for the simultaneous measurement of 3TC and AZT in fixed dose combinations. The methodology was validated and applied to determine the AZT+3TC contents in tablets from five different manufacturers, as well as their dissolution profile. The results obtained employing the proposed methodology was similar to methods using first derivative technique and HPLC.
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spelling Simultaneous spectrophotometric determination of lamivudine and zidovudine in fixed dose combinations using multivariate calibrationmultivariate calibrationlamivudine (3TC)zidovudine (AZT)The simultaneous determination of two or more active components in pharmaceutical preparations, without previous chemical separation, is a common analytical problem. Published works describe the determination of AZT and 3TC separately, as raw material or in different pharmaceutical preparations. In this work, a method using UV spectroscopy and multivariate calibration is described for the simultaneous measurement of 3TC and AZT in fixed dose combinations. The methodology was validated and applied to determine the AZT+3TC contents in tablets from five different manufacturers, as well as their dissolution profile. The results obtained employing the proposed methodology was similar to methods using first derivative technique and HPLC.Sociedade Brasileira de Química2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000500022Química Nova v.34 n.5 2011reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422011000500022info:eu-repo/semantics/openAccessGrangeiro Jr.,SeverinoAlbuquerque,Miracy M.Santana,Davi P.Pimentel,Maria FernandaSilva,Reniere H. daSimões,Simone S.eng2011-07-18T00:00:00Zoai:scielo:S0100-40422011000500022Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2011-07-18T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Simultaneous spectrophotometric determination of lamivudine and zidovudine in fixed dose combinations using multivariate calibration
title Simultaneous spectrophotometric determination of lamivudine and zidovudine in fixed dose combinations using multivariate calibration
spellingShingle Simultaneous spectrophotometric determination of lamivudine and zidovudine in fixed dose combinations using multivariate calibration
Grangeiro Jr.,Severino
multivariate calibration
lamivudine (3TC)
zidovudine (AZT)
title_short Simultaneous spectrophotometric determination of lamivudine and zidovudine in fixed dose combinations using multivariate calibration
title_full Simultaneous spectrophotometric determination of lamivudine and zidovudine in fixed dose combinations using multivariate calibration
title_fullStr Simultaneous spectrophotometric determination of lamivudine and zidovudine in fixed dose combinations using multivariate calibration
title_full_unstemmed Simultaneous spectrophotometric determination of lamivudine and zidovudine in fixed dose combinations using multivariate calibration
title_sort Simultaneous spectrophotometric determination of lamivudine and zidovudine in fixed dose combinations using multivariate calibration
author Grangeiro Jr.,Severino
author_facet Grangeiro Jr.,Severino
Albuquerque,Miracy M.
Santana,Davi P.
Pimentel,Maria Fernanda
Silva,Reniere H. da
Simões,Simone S.
author_role author
author2 Albuquerque,Miracy M.
Santana,Davi P.
Pimentel,Maria Fernanda
Silva,Reniere H. da
Simões,Simone S.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Grangeiro Jr.,Severino
Albuquerque,Miracy M.
Santana,Davi P.
Pimentel,Maria Fernanda
Silva,Reniere H. da
Simões,Simone S.
dc.subject.por.fl_str_mv multivariate calibration
lamivudine (3TC)
zidovudine (AZT)
topic multivariate calibration
lamivudine (3TC)
zidovudine (AZT)
description The simultaneous determination of two or more active components in pharmaceutical preparations, without previous chemical separation, is a common analytical problem. Published works describe the determination of AZT and 3TC separately, as raw material or in different pharmaceutical preparations. In this work, a method using UV spectroscopy and multivariate calibration is described for the simultaneous measurement of 3TC and AZT in fixed dose combinations. The methodology was validated and applied to determine the AZT+3TC contents in tablets from five different manufacturers, as well as their dissolution profile. The results obtained employing the proposed methodology was similar to methods using first derivative technique and HPLC.
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000500022
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000500022
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422011000500022
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.34 n.5 2011
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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