Multivariate spectroscopic determination of the lamivudine-zidovudine association

Detalhes bibliográficos
Autor(a) principal: Cordeiro,Gilcélia A
Data de Publicação: 2011
Outros Autores: Nagata,Noemi, Messerschmidt,Iara, Peralta-Zamora,Patricio, Rodrigues,Letícia N. C
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011000200020
Resumo: The multivariate spectroscopic determination of lamivudine-zidovudine associations was carried out by partial least square regression (PLS). This model was developed from 20 synthetic mixtures using mean-centered spectral data acquired from 190 to 350 nm and with 3 latent variables. External validation was performed with 6 synthetic mixtures providing prediction errors close to 1%. Moreover, the analysis of commercial drugs showed good results with prediction errors lower than 10%. The multivariate methodology was validated according to International Conference on Harmonization (ICH) criteria, demonstrating precision, accuracy and robustness within legal requirements.
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spelling Multivariate spectroscopic determination of the lamivudine-zidovudine associationlamivudinezidovudineelectronic spectroscopymultivariate calibrationThe multivariate spectroscopic determination of lamivudine-zidovudine associations was carried out by partial least square regression (PLS). This model was developed from 20 synthetic mixtures using mean-centered spectral data acquired from 190 to 350 nm and with 3 latent variables. External validation was performed with 6 synthetic mixtures providing prediction errors close to 1%. Moreover, the analysis of commercial drugs showed good results with prediction errors lower than 10%. The multivariate methodology was validated according to International Conference on Harmonization (ICH) criteria, demonstrating precision, accuracy and robustness within legal requirements.Sociedade Brasileira de Química2011-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011000200020Journal of the Brazilian Chemical Society v.22 n.2 2011reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532011000200020info:eu-repo/semantics/openAccessCordeiro,Gilcélia ANagata,NoemiMesserschmidt,IaraPeralta-Zamora,PatricioRodrigues,Letícia N. Ceng2011-02-14T00:00:00Zoai:scielo:S0103-50532011000200020Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2011-02-14T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Multivariate spectroscopic determination of the lamivudine-zidovudine association
title Multivariate spectroscopic determination of the lamivudine-zidovudine association
spellingShingle Multivariate spectroscopic determination of the lamivudine-zidovudine association
Cordeiro,Gilcélia A
lamivudine
zidovudine
electronic spectroscopy
multivariate calibration
title_short Multivariate spectroscopic determination of the lamivudine-zidovudine association
title_full Multivariate spectroscopic determination of the lamivudine-zidovudine association
title_fullStr Multivariate spectroscopic determination of the lamivudine-zidovudine association
title_full_unstemmed Multivariate spectroscopic determination of the lamivudine-zidovudine association
title_sort Multivariate spectroscopic determination of the lamivudine-zidovudine association
author Cordeiro,Gilcélia A
author_facet Cordeiro,Gilcélia A
Nagata,Noemi
Messerschmidt,Iara
Peralta-Zamora,Patricio
Rodrigues,Letícia N. C
author_role author
author2 Nagata,Noemi
Messerschmidt,Iara
Peralta-Zamora,Patricio
Rodrigues,Letícia N. C
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Cordeiro,Gilcélia A
Nagata,Noemi
Messerschmidt,Iara
Peralta-Zamora,Patricio
Rodrigues,Letícia N. C
dc.subject.por.fl_str_mv lamivudine
zidovudine
electronic spectroscopy
multivariate calibration
topic lamivudine
zidovudine
electronic spectroscopy
multivariate calibration
description The multivariate spectroscopic determination of lamivudine-zidovudine associations was carried out by partial least square regression (PLS). This model was developed from 20 synthetic mixtures using mean-centered spectral data acquired from 190 to 350 nm and with 3 latent variables. External validation was performed with 6 synthetic mixtures providing prediction errors close to 1%. Moreover, the analysis of commercial drugs showed good results with prediction errors lower than 10%. The multivariate methodology was validated according to International Conference on Harmonization (ICH) criteria, demonstrating precision, accuracy and robustness within legal requirements.
publishDate 2011
dc.date.none.fl_str_mv 2011-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011000200020
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011000200020
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532011000200020
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.22 n.2 2011
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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