Development and physicochemical characterization of dexamethasone-loaded polymeric nanocapsule suspensions

Detalhes bibliográficos
Autor(a) principal: Friedrich,Rossana Barcellos
Data de Publicação: 2008
Outros Autores: Fontana,Marcia Camponogara, Beck,Ruy Carlos R., Pohlmann,Adriana Raffin, Guterres,Silvia Stanisçuaski
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000500038
Resumo: The influence of drug concentration, oil phase, and surfactants on the characteristics of dexamethasone-loaded nanocapsules was investigated. The best formulations were obtained at dexamethasone concentrations of 0.25 and 0.50 mg.mL-1 (encapsulation efficiency: 80-90%; mean size: 189-253 nm). The type of oil phase influenced only the stability of dexamethasone-loaded nanocapsules. The association of polysorbate 80 and sorbitan monooleate provided a more stable formulation. Sunflower oil and sorbitan sesquioleate used for the first time as oil phase and surfactant for nanocapsules, respectively, have allowed obtaining suspensions with low mean size and narrow size distribution.
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spelling Development and physicochemical characterization of dexamethasone-loaded polymeric nanocapsule suspensionsdexamethasonenanocapsulesnanoparticlesThe influence of drug concentration, oil phase, and surfactants on the characteristics of dexamethasone-loaded nanocapsules was investigated. The best formulations were obtained at dexamethasone concentrations of 0.25 and 0.50 mg.mL-1 (encapsulation efficiency: 80-90%; mean size: 189-253 nm). The type of oil phase influenced only the stability of dexamethasone-loaded nanocapsules. The association of polysorbate 80 and sorbitan monooleate provided a more stable formulation. Sunflower oil and sorbitan sesquioleate used for the first time as oil phase and surfactant for nanocapsules, respectively, have allowed obtaining suspensions with low mean size and narrow size distribution.Sociedade Brasileira de Química2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000500038Química Nova v.31 n.5 2008reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422008000500038info:eu-repo/semantics/openAccessFriedrich,Rossana BarcellosFontana,Marcia CamponogaraBeck,Ruy Carlos R.Pohlmann,Adriana RaffinGuterres,Silvia Stanisçuaskieng2008-09-12T00:00:00Zoai:scielo:S0100-40422008000500038Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2008-09-12T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Development and physicochemical characterization of dexamethasone-loaded polymeric nanocapsule suspensions
title Development and physicochemical characterization of dexamethasone-loaded polymeric nanocapsule suspensions
spellingShingle Development and physicochemical characterization of dexamethasone-loaded polymeric nanocapsule suspensions
Friedrich,Rossana Barcellos
dexamethasone
nanocapsules
nanoparticles
title_short Development and physicochemical characterization of dexamethasone-loaded polymeric nanocapsule suspensions
title_full Development and physicochemical characterization of dexamethasone-loaded polymeric nanocapsule suspensions
title_fullStr Development and physicochemical characterization of dexamethasone-loaded polymeric nanocapsule suspensions
title_full_unstemmed Development and physicochemical characterization of dexamethasone-loaded polymeric nanocapsule suspensions
title_sort Development and physicochemical characterization of dexamethasone-loaded polymeric nanocapsule suspensions
author Friedrich,Rossana Barcellos
author_facet Friedrich,Rossana Barcellos
Fontana,Marcia Camponogara
Beck,Ruy Carlos R.
Pohlmann,Adriana Raffin
Guterres,Silvia Stanisçuaski
author_role author
author2 Fontana,Marcia Camponogara
Beck,Ruy Carlos R.
Pohlmann,Adriana Raffin
Guterres,Silvia Stanisçuaski
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Friedrich,Rossana Barcellos
Fontana,Marcia Camponogara
Beck,Ruy Carlos R.
Pohlmann,Adriana Raffin
Guterres,Silvia Stanisçuaski
dc.subject.por.fl_str_mv dexamethasone
nanocapsules
nanoparticles
topic dexamethasone
nanocapsules
nanoparticles
description The influence of drug concentration, oil phase, and surfactants on the characteristics of dexamethasone-loaded nanocapsules was investigated. The best formulations were obtained at dexamethasone concentrations of 0.25 and 0.50 mg.mL-1 (encapsulation efficiency: 80-90%; mean size: 189-253 nm). The type of oil phase influenced only the stability of dexamethasone-loaded nanocapsules. The association of polysorbate 80 and sorbitan monooleate provided a more stable formulation. Sunflower oil and sorbitan sesquioleate used for the first time as oil phase and surfactant for nanocapsules, respectively, have allowed obtaining suspensions with low mean size and narrow size distribution.
publishDate 2008
dc.date.none.fl_str_mv 2008-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000500038
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000500038
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422008000500038
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.31 n.5 2008
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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