Available evidence on HIFU for focal treatment of prostate cancer: a systematic review
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | International Braz J Urol (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382022000200263 |
Resumo: | ABSTRACT Purpose: Prostate cancer (PCa) is the second most common oncologic disease among men. Radical treatment with curative intent provides good oncological results for PCa survivors, although definitive therapy is associated with significant number of serious side-effects. In modern-era of medicine tissue-sparing techniques, such as focal HIFU, have been proposed for PCa patients in order to provide cancer control equivalent to the standard-of-care procedures while reducing morbidities and complications. The aim of this systematic review was to summarise the available evidence about focal HIFU therapy as a primary treatment for localized PCa. Material and methods: We conducted a comprehensive literature review of focal HIFU therapy in the MEDLINE database (PROSPERO: CRD42021235581). Articles published in the English language between 2010 and 2020 with more than 50 patients were included. Results: Clinically significant in-field recurrence and out-of-field progression were detected to 22% and 29% PCa patients, respectively. Higher ISUP grade group, more positive cores at biopsy and bilateral disease were identified as the main risk factors for disease recurrence. The most common strategy for recurrence management was definitive therapy. Six months after focal HIFU therapy 98% of patients were totally continent and 80% of patients retained sufficient erections for sexual intercourse. The majority of complications presented in the early postoperative period and were classified as low-grade. Conclusions: This review highlights that focal HIFU therapy appears to be a safe procedure, while short-term cancer control rate is encouraging. Though, second-line treatment or active surveillance seems to be necessary in a significant number of patients. |
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Available evidence on HIFU for focal treatment of prostate cancer: a systematic reviewProstate cancer, familial [Supplementary Concept]High-Intensity Focused Ultrasound AblationTechnologycomplications [Subheading]ABSTRACT Purpose: Prostate cancer (PCa) is the second most common oncologic disease among men. Radical treatment with curative intent provides good oncological results for PCa survivors, although definitive therapy is associated with significant number of serious side-effects. In modern-era of medicine tissue-sparing techniques, such as focal HIFU, have been proposed for PCa patients in order to provide cancer control equivalent to the standard-of-care procedures while reducing morbidities and complications. The aim of this systematic review was to summarise the available evidence about focal HIFU therapy as a primary treatment for localized PCa. Material and methods: We conducted a comprehensive literature review of focal HIFU therapy in the MEDLINE database (PROSPERO: CRD42021235581). Articles published in the English language between 2010 and 2020 with more than 50 patients were included. Results: Clinically significant in-field recurrence and out-of-field progression were detected to 22% and 29% PCa patients, respectively. Higher ISUP grade group, more positive cores at biopsy and bilateral disease were identified as the main risk factors for disease recurrence. The most common strategy for recurrence management was definitive therapy. Six months after focal HIFU therapy 98% of patients were totally continent and 80% of patients retained sufficient erections for sexual intercourse. The majority of complications presented in the early postoperative period and were classified as low-grade. Conclusions: This review highlights that focal HIFU therapy appears to be a safe procedure, while short-term cancer control rate is encouraging. Though, second-line treatment or active surveillance seems to be necessary in a significant number of patients.Sociedade Brasileira de Urologia2022-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382022000200263International braz j urol v.48 n.2 2022reponame:International Braz J Urol (Online)instname:Sociedade Brasileira de Urologia (SBU)instacron:SBU10.1590/s1677-5538.ibju.2021.0091info:eu-repo/semantics/openAccessBakavicius,ArnasMarra,GiancarloMacek,PetrRobertson,CaryAbreu,Andre L.George,Arvin K.Malavaud,BernardColoby,PatrickRischmann,PascalMoschini,MarcoRastinehad,Ardeshir R.Sidana,AbhinavStabile,ArmandoTourinho-Barbosa,RafaelRosette,Jean de laAhmed,HashimPolascik,ThomasCathelineau,XavierSanchez-Salas,Rafaeleng2022-03-08T00:00:00Zoai:scielo:S1677-55382022000200263Revistahttp://www.brazjurol.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||brazjurol@brazjurol.com.br1677-61191677-5538opendoar:2022-03-08T00:00International Braz J Urol (Online) - Sociedade Brasileira de Urologia (SBU)false |
dc.title.none.fl_str_mv |
Available evidence on HIFU for focal treatment of prostate cancer: a systematic review |
title |
Available evidence on HIFU for focal treatment of prostate cancer: a systematic review |
spellingShingle |
Available evidence on HIFU for focal treatment of prostate cancer: a systematic review Bakavicius,Arnas Prostate cancer, familial [Supplementary Concept] High-Intensity Focused Ultrasound Ablation Technology complications [Subheading] |
title_short |
Available evidence on HIFU for focal treatment of prostate cancer: a systematic review |
title_full |
Available evidence on HIFU for focal treatment of prostate cancer: a systematic review |
title_fullStr |
Available evidence on HIFU for focal treatment of prostate cancer: a systematic review |
title_full_unstemmed |
Available evidence on HIFU for focal treatment of prostate cancer: a systematic review |
title_sort |
Available evidence on HIFU for focal treatment of prostate cancer: a systematic review |
author |
Bakavicius,Arnas |
author_facet |
Bakavicius,Arnas Marra,Giancarlo Macek,Petr Robertson,Cary Abreu,Andre L. George,Arvin K. Malavaud,Bernard Coloby,Patrick Rischmann,Pascal Moschini,Marco Rastinehad,Ardeshir R. Sidana,Abhinav Stabile,Armando Tourinho-Barbosa,Rafael Rosette,Jean de la Ahmed,Hashim Polascik,Thomas Cathelineau,Xavier Sanchez-Salas,Rafael |
author_role |
author |
author2 |
Marra,Giancarlo Macek,Petr Robertson,Cary Abreu,Andre L. George,Arvin K. Malavaud,Bernard Coloby,Patrick Rischmann,Pascal Moschini,Marco Rastinehad,Ardeshir R. Sidana,Abhinav Stabile,Armando Tourinho-Barbosa,Rafael Rosette,Jean de la Ahmed,Hashim Polascik,Thomas Cathelineau,Xavier Sanchez-Salas,Rafael |
author2_role |
author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Bakavicius,Arnas Marra,Giancarlo Macek,Petr Robertson,Cary Abreu,Andre L. George,Arvin K. Malavaud,Bernard Coloby,Patrick Rischmann,Pascal Moschini,Marco Rastinehad,Ardeshir R. Sidana,Abhinav Stabile,Armando Tourinho-Barbosa,Rafael Rosette,Jean de la Ahmed,Hashim Polascik,Thomas Cathelineau,Xavier Sanchez-Salas,Rafael |
dc.subject.por.fl_str_mv |
Prostate cancer, familial [Supplementary Concept] High-Intensity Focused Ultrasound Ablation Technology complications [Subheading] |
topic |
Prostate cancer, familial [Supplementary Concept] High-Intensity Focused Ultrasound Ablation Technology complications [Subheading] |
description |
ABSTRACT Purpose: Prostate cancer (PCa) is the second most common oncologic disease among men. Radical treatment with curative intent provides good oncological results for PCa survivors, although definitive therapy is associated with significant number of serious side-effects. In modern-era of medicine tissue-sparing techniques, such as focal HIFU, have been proposed for PCa patients in order to provide cancer control equivalent to the standard-of-care procedures while reducing morbidities and complications. The aim of this systematic review was to summarise the available evidence about focal HIFU therapy as a primary treatment for localized PCa. Material and methods: We conducted a comprehensive literature review of focal HIFU therapy in the MEDLINE database (PROSPERO: CRD42021235581). Articles published in the English language between 2010 and 2020 with more than 50 patients were included. Results: Clinically significant in-field recurrence and out-of-field progression were detected to 22% and 29% PCa patients, respectively. Higher ISUP grade group, more positive cores at biopsy and bilateral disease were identified as the main risk factors for disease recurrence. The most common strategy for recurrence management was definitive therapy. Six months after focal HIFU therapy 98% of patients were totally continent and 80% of patients retained sufficient erections for sexual intercourse. The majority of complications presented in the early postoperative period and were classified as low-grade. Conclusions: This review highlights that focal HIFU therapy appears to be a safe procedure, while short-term cancer control rate is encouraging. Though, second-line treatment or active surveillance seems to be necessary in a significant number of patients. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382022000200263 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382022000200263 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/s1677-5538.ibju.2021.0091 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Urologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Urologia |
dc.source.none.fl_str_mv |
International braz j urol v.48 n.2 2022 reponame:International Braz J Urol (Online) instname:Sociedade Brasileira de Urologia (SBU) instacron:SBU |
instname_str |
Sociedade Brasileira de Urologia (SBU) |
instacron_str |
SBU |
institution |
SBU |
reponame_str |
International Braz J Urol (Online) |
collection |
International Braz J Urol (Online) |
repository.name.fl_str_mv |
International Braz J Urol (Online) - Sociedade Brasileira de Urologia (SBU) |
repository.mail.fl_str_mv |
||brazjurol@brazjurol.com.br |
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