External validation of nomogram to predict inguinal lymph node metastasis in patients with penile cancer and clinically negative lymph nodes
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | International Braz J Urol (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382019000400671 |
Resumo: | ABSTRACT Introduction Penile cancer (PC) occurs less frequently in Europe and in the United States than in South America and parts of Africa. Lymph node (LN) involvement is the most important prognostic factor, and inguinal LN (ILN) dissection can be curative; however, ILN dissection has high morbidity. A nomogram was previously developed based on clinicopathological features of PC to predict ILN metastases. Our objective was to conduct an external validation of the previously developed nomogram based on our population. Materials and methods We included men with cN0 ILNs who underwent ILN dissection for penile carcinoma between 2000 and 2014. We performed external validation of the nomogram considering three different external validation methods: k-fold, leave-one-out, and bootstrap. We also analyzed prognostic variables. Performance was quantified in terms of calibration and discrimination (receiver operator characteristic curve). A logistic regression model for positive ILNs was developed based on clinicopathological features of PC. Results We analyzed 65 men who underwent ILN dissection (cN0). The mean age was 56.8 years. Of 65 men, 24 (36.9%) presented with positive LNs. A median 21 ILNs were removed. Considering the three different methods used, we concluded that the previously developed nomogram was not suitable for our sample. Conclusions In our study, the previously developed nomogram that was applied to our population had low accuracy and low precision for correctly identifying patients with PC who have positive ILNs. |
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International Braz J Urol (Online) |
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External validation of nomogram to predict inguinal lymph node metastasis in patients with penile cancer and clinically negative lymph nodesNomogramsLymphLymphatic MetastasisPenile NeoplasmsABSTRACT Introduction Penile cancer (PC) occurs less frequently in Europe and in the United States than in South America and parts of Africa. Lymph node (LN) involvement is the most important prognostic factor, and inguinal LN (ILN) dissection can be curative; however, ILN dissection has high morbidity. A nomogram was previously developed based on clinicopathological features of PC to predict ILN metastases. Our objective was to conduct an external validation of the previously developed nomogram based on our population. Materials and methods We included men with cN0 ILNs who underwent ILN dissection for penile carcinoma between 2000 and 2014. We performed external validation of the nomogram considering three different external validation methods: k-fold, leave-one-out, and bootstrap. We also analyzed prognostic variables. Performance was quantified in terms of calibration and discrimination (receiver operator characteristic curve). A logistic regression model for positive ILNs was developed based on clinicopathological features of PC. Results We analyzed 65 men who underwent ILN dissection (cN0). The mean age was 56.8 years. Of 65 men, 24 (36.9%) presented with positive LNs. A median 21 ILNs were removed. Considering the three different methods used, we concluded that the previously developed nomogram was not suitable for our sample. Conclusions In our study, the previously developed nomogram that was applied to our population had low accuracy and low precision for correctly identifying patients with PC who have positive ILNs.Sociedade Brasileira de Urologia2019-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382019000400671International braz j urol v.45 n.4 2019reponame:International Braz J Urol (Online)instname:Sociedade Brasileira de Urologia (SBU)instacron:SBU10.1590/s1677-5538.ibju.2018.0756info:eu-repo/semantics/openAccessMaciel,Carlos Vaz de MeloMachado,Roberto DiasMorini,Mariana AndoziaMattos,Pablo Aloisio LimaReis,Ricardo dosReis,Rodolfo Borges dosGuimarães,Gustavo CardosoCunha,Isabela Werneck daFaria,Eliney Ferreiraeng2019-08-30T00:00:00Zoai:scielo:S1677-55382019000400671Revistahttp://www.brazjurol.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||brazjurol@brazjurol.com.br1677-61191677-5538opendoar:2019-08-30T00:00International Braz J Urol (Online) - Sociedade Brasileira de Urologia (SBU)false |
dc.title.none.fl_str_mv |
External validation of nomogram to predict inguinal lymph node metastasis in patients with penile cancer and clinically negative lymph nodes |
title |
External validation of nomogram to predict inguinal lymph node metastasis in patients with penile cancer and clinically negative lymph nodes |
spellingShingle |
External validation of nomogram to predict inguinal lymph node metastasis in patients with penile cancer and clinically negative lymph nodes Maciel,Carlos Vaz de Melo Nomograms Lymph Lymphatic Metastasis Penile Neoplasms |
title_short |
External validation of nomogram to predict inguinal lymph node metastasis in patients with penile cancer and clinically negative lymph nodes |
title_full |
External validation of nomogram to predict inguinal lymph node metastasis in patients with penile cancer and clinically negative lymph nodes |
title_fullStr |
External validation of nomogram to predict inguinal lymph node metastasis in patients with penile cancer and clinically negative lymph nodes |
title_full_unstemmed |
External validation of nomogram to predict inguinal lymph node metastasis in patients with penile cancer and clinically negative lymph nodes |
title_sort |
External validation of nomogram to predict inguinal lymph node metastasis in patients with penile cancer and clinically negative lymph nodes |
author |
Maciel,Carlos Vaz de Melo |
author_facet |
Maciel,Carlos Vaz de Melo Machado,Roberto Dias Morini,Mariana Andozia Mattos,Pablo Aloisio Lima Reis,Ricardo dos Reis,Rodolfo Borges dos Guimarães,Gustavo Cardoso Cunha,Isabela Werneck da Faria,Eliney Ferreira |
author_role |
author |
author2 |
Machado,Roberto Dias Morini,Mariana Andozia Mattos,Pablo Aloisio Lima Reis,Ricardo dos Reis,Rodolfo Borges dos Guimarães,Gustavo Cardoso Cunha,Isabela Werneck da Faria,Eliney Ferreira |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Maciel,Carlos Vaz de Melo Machado,Roberto Dias Morini,Mariana Andozia Mattos,Pablo Aloisio Lima Reis,Ricardo dos Reis,Rodolfo Borges dos Guimarães,Gustavo Cardoso Cunha,Isabela Werneck da Faria,Eliney Ferreira |
dc.subject.por.fl_str_mv |
Nomograms Lymph Lymphatic Metastasis Penile Neoplasms |
topic |
Nomograms Lymph Lymphatic Metastasis Penile Neoplasms |
description |
ABSTRACT Introduction Penile cancer (PC) occurs less frequently in Europe and in the United States than in South America and parts of Africa. Lymph node (LN) involvement is the most important prognostic factor, and inguinal LN (ILN) dissection can be curative; however, ILN dissection has high morbidity. A nomogram was previously developed based on clinicopathological features of PC to predict ILN metastases. Our objective was to conduct an external validation of the previously developed nomogram based on our population. Materials and methods We included men with cN0 ILNs who underwent ILN dissection for penile carcinoma between 2000 and 2014. We performed external validation of the nomogram considering three different external validation methods: k-fold, leave-one-out, and bootstrap. We also analyzed prognostic variables. Performance was quantified in terms of calibration and discrimination (receiver operator characteristic curve). A logistic regression model for positive ILNs was developed based on clinicopathological features of PC. Results We analyzed 65 men who underwent ILN dissection (cN0). The mean age was 56.8 years. Of 65 men, 24 (36.9%) presented with positive LNs. A median 21 ILNs were removed. Considering the three different methods used, we concluded that the previously developed nomogram was not suitable for our sample. Conclusions In our study, the previously developed nomogram that was applied to our population had low accuracy and low precision for correctly identifying patients with PC who have positive ILNs. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382019000400671 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382019000400671 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/s1677-5538.ibju.2018.0756 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Urologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Urologia |
dc.source.none.fl_str_mv |
International braz j urol v.45 n.4 2019 reponame:International Braz J Urol (Online) instname:Sociedade Brasileira de Urologia (SBU) instacron:SBU |
instname_str |
Sociedade Brasileira de Urologia (SBU) |
instacron_str |
SBU |
institution |
SBU |
reponame_str |
International Braz J Urol (Online) |
collection |
International Braz J Urol (Online) |
repository.name.fl_str_mv |
International Braz J Urol (Online) - Sociedade Brasileira de Urologia (SBU) |
repository.mail.fl_str_mv |
||brazjurol@brazjurol.com.br |
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1750318076853747712 |