External validation of nomogram to predict inguinal lymph node metastasis in patients with penile cancer and clinically negative lymph nodes

Detalhes bibliográficos
Autor(a) principal: Maciel,Carlos Vaz de Melo
Data de Publicação: 2019
Outros Autores: Machado,Roberto Dias, Morini,Mariana Andozia, Mattos,Pablo Aloisio Lima, Reis,Ricardo dos, Reis,Rodolfo Borges dos, Guimarães,Gustavo Cardoso, Cunha,Isabela Werneck da, Faria,Eliney Ferreira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: International Braz J Urol (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382019000400671
Resumo: ABSTRACT Introduction Penile cancer (PC) occurs less frequently in Europe and in the United States than in South America and parts of Africa. Lymph node (LN) involvement is the most important prognostic factor, and inguinal LN (ILN) dissection can be curative; however, ILN dissection has high morbidity. A nomogram was previously developed based on clinicopathological features of PC to predict ILN metastases. Our objective was to conduct an external validation of the previously developed nomogram based on our population. Materials and methods We included men with cN0 ILNs who underwent ILN dissection for penile carcinoma between 2000 and 2014. We performed external validation of the nomogram considering three different external validation methods: k-fold, leave-one-out, and bootstrap. We also analyzed prognostic variables. Performance was quantified in terms of calibration and discrimination (receiver operator characteristic curve). A logistic regression model for positive ILNs was developed based on clinicopathological features of PC. Results We analyzed 65 men who underwent ILN dissection (cN0). The mean age was 56.8 years. Of 65 men, 24 (36.9%) presented with positive LNs. A median 21 ILNs were removed. Considering the three different methods used, we concluded that the previously developed nomogram was not suitable for our sample. Conclusions In our study, the previously developed nomogram that was applied to our population had low accuracy and low precision for correctly identifying patients with PC who have positive ILNs.
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spelling External validation of nomogram to predict inguinal lymph node metastasis in patients with penile cancer and clinically negative lymph nodesNomogramsLymphLymphatic MetastasisPenile NeoplasmsABSTRACT Introduction Penile cancer (PC) occurs less frequently in Europe and in the United States than in South America and parts of Africa. Lymph node (LN) involvement is the most important prognostic factor, and inguinal LN (ILN) dissection can be curative; however, ILN dissection has high morbidity. A nomogram was previously developed based on clinicopathological features of PC to predict ILN metastases. Our objective was to conduct an external validation of the previously developed nomogram based on our population. Materials and methods We included men with cN0 ILNs who underwent ILN dissection for penile carcinoma between 2000 and 2014. We performed external validation of the nomogram considering three different external validation methods: k-fold, leave-one-out, and bootstrap. We also analyzed prognostic variables. Performance was quantified in terms of calibration and discrimination (receiver operator characteristic curve). A logistic regression model for positive ILNs was developed based on clinicopathological features of PC. Results We analyzed 65 men who underwent ILN dissection (cN0). The mean age was 56.8 years. Of 65 men, 24 (36.9%) presented with positive LNs. A median 21 ILNs were removed. Considering the three different methods used, we concluded that the previously developed nomogram was not suitable for our sample. Conclusions In our study, the previously developed nomogram that was applied to our population had low accuracy and low precision for correctly identifying patients with PC who have positive ILNs.Sociedade Brasileira de Urologia2019-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382019000400671International braz j urol v.45 n.4 2019reponame:International Braz J Urol (Online)instname:Sociedade Brasileira de Urologia (SBU)instacron:SBU10.1590/s1677-5538.ibju.2018.0756info:eu-repo/semantics/openAccessMaciel,Carlos Vaz de MeloMachado,Roberto DiasMorini,Mariana AndoziaMattos,Pablo Aloisio LimaReis,Ricardo dosReis,Rodolfo Borges dosGuimarães,Gustavo CardosoCunha,Isabela Werneck daFaria,Eliney Ferreiraeng2019-08-30T00:00:00Zoai:scielo:S1677-55382019000400671Revistahttp://www.brazjurol.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||brazjurol@brazjurol.com.br1677-61191677-5538opendoar:2019-08-30T00:00International Braz J Urol (Online) - Sociedade Brasileira de Urologia (SBU)false
dc.title.none.fl_str_mv External validation of nomogram to predict inguinal lymph node metastasis in patients with penile cancer and clinically negative lymph nodes
title External validation of nomogram to predict inguinal lymph node metastasis in patients with penile cancer and clinically negative lymph nodes
spellingShingle External validation of nomogram to predict inguinal lymph node metastasis in patients with penile cancer and clinically negative lymph nodes
Maciel,Carlos Vaz de Melo
Nomograms
Lymph
Lymphatic Metastasis
Penile Neoplasms
title_short External validation of nomogram to predict inguinal lymph node metastasis in patients with penile cancer and clinically negative lymph nodes
title_full External validation of nomogram to predict inguinal lymph node metastasis in patients with penile cancer and clinically negative lymph nodes
title_fullStr External validation of nomogram to predict inguinal lymph node metastasis in patients with penile cancer and clinically negative lymph nodes
title_full_unstemmed External validation of nomogram to predict inguinal lymph node metastasis in patients with penile cancer and clinically negative lymph nodes
title_sort External validation of nomogram to predict inguinal lymph node metastasis in patients with penile cancer and clinically negative lymph nodes
author Maciel,Carlos Vaz de Melo
author_facet Maciel,Carlos Vaz de Melo
Machado,Roberto Dias
Morini,Mariana Andozia
Mattos,Pablo Aloisio Lima
Reis,Ricardo dos
Reis,Rodolfo Borges dos
Guimarães,Gustavo Cardoso
Cunha,Isabela Werneck da
Faria,Eliney Ferreira
author_role author
author2 Machado,Roberto Dias
Morini,Mariana Andozia
Mattos,Pablo Aloisio Lima
Reis,Ricardo dos
Reis,Rodolfo Borges dos
Guimarães,Gustavo Cardoso
Cunha,Isabela Werneck da
Faria,Eliney Ferreira
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Maciel,Carlos Vaz de Melo
Machado,Roberto Dias
Morini,Mariana Andozia
Mattos,Pablo Aloisio Lima
Reis,Ricardo dos
Reis,Rodolfo Borges dos
Guimarães,Gustavo Cardoso
Cunha,Isabela Werneck da
Faria,Eliney Ferreira
dc.subject.por.fl_str_mv Nomograms
Lymph
Lymphatic Metastasis
Penile Neoplasms
topic Nomograms
Lymph
Lymphatic Metastasis
Penile Neoplasms
description ABSTRACT Introduction Penile cancer (PC) occurs less frequently in Europe and in the United States than in South America and parts of Africa. Lymph node (LN) involvement is the most important prognostic factor, and inguinal LN (ILN) dissection can be curative; however, ILN dissection has high morbidity. A nomogram was previously developed based on clinicopathological features of PC to predict ILN metastases. Our objective was to conduct an external validation of the previously developed nomogram based on our population. Materials and methods We included men with cN0 ILNs who underwent ILN dissection for penile carcinoma between 2000 and 2014. We performed external validation of the nomogram considering three different external validation methods: k-fold, leave-one-out, and bootstrap. We also analyzed prognostic variables. Performance was quantified in terms of calibration and discrimination (receiver operator characteristic curve). A logistic regression model for positive ILNs was developed based on clinicopathological features of PC. Results We analyzed 65 men who underwent ILN dissection (cN0). The mean age was 56.8 years. Of 65 men, 24 (36.9%) presented with positive LNs. A median 21 ILNs were removed. Considering the three different methods used, we concluded that the previously developed nomogram was not suitable for our sample. Conclusions In our study, the previously developed nomogram that was applied to our population had low accuracy and low precision for correctly identifying patients with PC who have positive ILNs.
publishDate 2019
dc.date.none.fl_str_mv 2019-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382019000400671
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382019000400671
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/s1677-5538.ibju.2018.0756
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Urologia
publisher.none.fl_str_mv Sociedade Brasileira de Urologia
dc.source.none.fl_str_mv International braz j urol v.45 n.4 2019
reponame:International Braz J Urol (Online)
instname:Sociedade Brasileira de Urologia (SBU)
instacron:SBU
instname_str Sociedade Brasileira de Urologia (SBU)
instacron_str SBU
institution SBU
reponame_str International Braz J Urol (Online)
collection International Braz J Urol (Online)
repository.name.fl_str_mv International Braz J Urol (Online) - Sociedade Brasileira de Urologia (SBU)
repository.mail.fl_str_mv ||brazjurol@brazjurol.com.br
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