Incidence and treatment of malignant tumors of the genitourinary tract in renal transplant recipients
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | International Braz J Urol (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382018000500874 |
Resumo: | ABSTRACT Purpose: To provide data of the incidence and management of common urological malignancies in renal transplant recipients. Materials and Methods: We conducted a retrospective analysis of a prospective database from August 1967 to August 2015. A descriptive analysis of the sample was performed. Results: Among 1256 consecutive RTR a total of 88 patients developed malignancies (7%). There were 18 genitourinary tumors in the 16 patients (20.45 % of all malignant neoplasms), incidence of 1.27%. The most common neoplasm encounter was renal cancer (38.8%), followed by urothelial carcinoma (33.3%). Median follow-up of transplantation was 197 months (R, 36-336). Mean time from RT to cancer diagnosis 89±70 months (R, 12-276). CsA and AZA was the most common immunosuppression regimen in 68.75%. Mean follow-up after diagnosis was 103±72 months (R 10-215). Recurrence free survival rate of 100%. Overall survival of 89.5% of the sample; there were two non-related cancer deaths during follow-up. Conclusions: The incidence of neoplasms in RTR was lower than in other series, with favorable functional and oncologic results after treatment. This suggests that actions to reduce the risk of these malignancies as well as a strict follow-up are mandatory for an early detection and treatment. |
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Incidence and treatment of malignant tumors of the genitourinary tract in renal transplant recipientsNeoplasmsUrinary TractKidney TransplantationABSTRACT Purpose: To provide data of the incidence and management of common urological malignancies in renal transplant recipients. Materials and Methods: We conducted a retrospective analysis of a prospective database from August 1967 to August 2015. A descriptive analysis of the sample was performed. Results: Among 1256 consecutive RTR a total of 88 patients developed malignancies (7%). There were 18 genitourinary tumors in the 16 patients (20.45 % of all malignant neoplasms), incidence of 1.27%. The most common neoplasm encounter was renal cancer (38.8%), followed by urothelial carcinoma (33.3%). Median follow-up of transplantation was 197 months (R, 36-336). Mean time from RT to cancer diagnosis 89±70 months (R, 12-276). CsA and AZA was the most common immunosuppression regimen in 68.75%. Mean follow-up after diagnosis was 103±72 months (R 10-215). Recurrence free survival rate of 100%. Overall survival of 89.5% of the sample; there were two non-related cancer deaths during follow-up. Conclusions: The incidence of neoplasms in RTR was lower than in other series, with favorable functional and oncologic results after treatment. This suggests that actions to reduce the risk of these malignancies as well as a strict follow-up are mandatory for an early detection and treatment.Sociedade Brasileira de Urologia2018-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382018000500874International braz j urol v.44 n.5 2018reponame:International Braz J Urol (Online)instname:Sociedade Brasileira de Urologia (SBU)instacron:SBU10.1590/s1677-5538.ibju.2017.0471info:eu-repo/semantics/openAccessManuel Ochoa-López,JuanGabilondo-Pliego,BernardoCollura-Merlier,SylvainHerrera-Cáceres,Jaime O.Sotomayor de Zavaleta,MarianoRodríguez-Covarrubias,Francisco TomásFeria-Bernal,GuillermoGabilondo-Navarro,FernandoCastillejos-Molina,Ricardo Alonsoeng2018-10-24T00:00:00Zoai:scielo:S1677-55382018000500874Revistahttp://www.brazjurol.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||brazjurol@brazjurol.com.br1677-61191677-5538opendoar:2018-10-24T00:00International Braz J Urol (Online) - Sociedade Brasileira de Urologia (SBU)false |
dc.title.none.fl_str_mv |
Incidence and treatment of malignant tumors of the genitourinary tract in renal transplant recipients |
title |
Incidence and treatment of malignant tumors of the genitourinary tract in renal transplant recipients |
spellingShingle |
Incidence and treatment of malignant tumors of the genitourinary tract in renal transplant recipients Manuel Ochoa-López,Juan Neoplasms Urinary Tract Kidney Transplantation |
title_short |
Incidence and treatment of malignant tumors of the genitourinary tract in renal transplant recipients |
title_full |
Incidence and treatment of malignant tumors of the genitourinary tract in renal transplant recipients |
title_fullStr |
Incidence and treatment of malignant tumors of the genitourinary tract in renal transplant recipients |
title_full_unstemmed |
Incidence and treatment of malignant tumors of the genitourinary tract in renal transplant recipients |
title_sort |
Incidence and treatment of malignant tumors of the genitourinary tract in renal transplant recipients |
author |
Manuel Ochoa-López,Juan |
author_facet |
Manuel Ochoa-López,Juan Gabilondo-Pliego,Bernardo Collura-Merlier,Sylvain Herrera-Cáceres,Jaime O. Sotomayor de Zavaleta,Mariano Rodríguez-Covarrubias,Francisco Tomás Feria-Bernal,Guillermo Gabilondo-Navarro,Fernando Castillejos-Molina,Ricardo Alonso |
author_role |
author |
author2 |
Gabilondo-Pliego,Bernardo Collura-Merlier,Sylvain Herrera-Cáceres,Jaime O. Sotomayor de Zavaleta,Mariano Rodríguez-Covarrubias,Francisco Tomás Feria-Bernal,Guillermo Gabilondo-Navarro,Fernando Castillejos-Molina,Ricardo Alonso |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Manuel Ochoa-López,Juan Gabilondo-Pliego,Bernardo Collura-Merlier,Sylvain Herrera-Cáceres,Jaime O. Sotomayor de Zavaleta,Mariano Rodríguez-Covarrubias,Francisco Tomás Feria-Bernal,Guillermo Gabilondo-Navarro,Fernando Castillejos-Molina,Ricardo Alonso |
dc.subject.por.fl_str_mv |
Neoplasms Urinary Tract Kidney Transplantation |
topic |
Neoplasms Urinary Tract Kidney Transplantation |
description |
ABSTRACT Purpose: To provide data of the incidence and management of common urological malignancies in renal transplant recipients. Materials and Methods: We conducted a retrospective analysis of a prospective database from August 1967 to August 2015. A descriptive analysis of the sample was performed. Results: Among 1256 consecutive RTR a total of 88 patients developed malignancies (7%). There were 18 genitourinary tumors in the 16 patients (20.45 % of all malignant neoplasms), incidence of 1.27%. The most common neoplasm encounter was renal cancer (38.8%), followed by urothelial carcinoma (33.3%). Median follow-up of transplantation was 197 months (R, 36-336). Mean time from RT to cancer diagnosis 89±70 months (R, 12-276). CsA and AZA was the most common immunosuppression regimen in 68.75%. Mean follow-up after diagnosis was 103±72 months (R 10-215). Recurrence free survival rate of 100%. Overall survival of 89.5% of the sample; there were two non-related cancer deaths during follow-up. Conclusions: The incidence of neoplasms in RTR was lower than in other series, with favorable functional and oncologic results after treatment. This suggests that actions to reduce the risk of these malignancies as well as a strict follow-up are mandatory for an early detection and treatment. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382018000500874 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382018000500874 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/s1677-5538.ibju.2017.0471 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Urologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Urologia |
dc.source.none.fl_str_mv |
International braz j urol v.44 n.5 2018 reponame:International Braz J Urol (Online) instname:Sociedade Brasileira de Urologia (SBU) instacron:SBU |
instname_str |
Sociedade Brasileira de Urologia (SBU) |
instacron_str |
SBU |
institution |
SBU |
reponame_str |
International Braz J Urol (Online) |
collection |
International Braz J Urol (Online) |
repository.name.fl_str_mv |
International Braz J Urol (Online) - Sociedade Brasileira de Urologia (SBU) |
repository.mail.fl_str_mv |
||brazjurol@brazjurol.com.br |
_version_ |
1750318076315828224 |