Effects of tin caulis dendrobium polysaccharide on the prevention of non-alcoholic fatty liver disease in rats

Detalhes bibliográficos
Autor(a) principal: Xu,Dingting
Data de Publicação: 2017
Outros Autores: Zhang,Hanyun, Wang,Xiaoying
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Zootecnia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-35982017000800652
Resumo: ABSTRACT We aimed to investigate the effects and mechanisms of tin caulis dendrobium polysaccharide on body weight and non-alcoholic fatty liver disease in Sprague-Dawleg rats. The rats were fed a high-fat diet (HFD) with or without tin caulis dendrobium polysaccharide for eight weeks. Body weight, liver function tests, serum and liver lipids, liver morphology, and the expression of PPARγ and UCP2 were assessed. Rats fed HFD exhibited more obvious weight gain, increased serum, and hepatic lipids. But the more tin caulis dendrobium polysaccharide they fed, the lower increase in weight, serum, and hepatic lipids of rats were found. Furthermore, the expression of PPARγ and UCP2 decreased in rats fed tin caulis dendrobium polysaccharide compared with HFD-fed rats. Tin caulis dendrobium polysaccharide may downregulate the expression of PPARγ and UCP2 in liver and protect against body weight gain and liver fat deposition.
id SBZ-1_be68eb75e4f43703a4ca58ec0e4e872b
oai_identifier_str oai:scielo:S1516-35982017000800652
network_acronym_str SBZ-1
network_name_str Revista Brasileira de Zootecnia (Online)
repository_id_str
spelling Effects of tin caulis dendrobium polysaccharide on the prevention of non-alcoholic fatty liver disease in ratsfatty liverhigh-fat dietinterventionmechanismsABSTRACT We aimed to investigate the effects and mechanisms of tin caulis dendrobium polysaccharide on body weight and non-alcoholic fatty liver disease in Sprague-Dawleg rats. The rats were fed a high-fat diet (HFD) with or without tin caulis dendrobium polysaccharide for eight weeks. Body weight, liver function tests, serum and liver lipids, liver morphology, and the expression of PPARγ and UCP2 were assessed. Rats fed HFD exhibited more obvious weight gain, increased serum, and hepatic lipids. But the more tin caulis dendrobium polysaccharide they fed, the lower increase in weight, serum, and hepatic lipids of rats were found. Furthermore, the expression of PPARγ and UCP2 decreased in rats fed tin caulis dendrobium polysaccharide compared with HFD-fed rats. Tin caulis dendrobium polysaccharide may downregulate the expression of PPARγ and UCP2 in liver and protect against body weight gain and liver fat deposition.Sociedade Brasileira de Zootecnia2017-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-35982017000800652Revista Brasileira de Zootecnia v.46 n.8 2017reponame:Revista Brasileira de Zootecnia (Online)instname:Sociedade Brasileira de Zootecnia (SBZ)instacron:SBZ10.1590/s1806-92902017000800004info:eu-repo/semantics/openAccessXu,DingtingZhang,HanyunWang,Xiaoyingeng2017-10-11T00:00:00Zoai:scielo:S1516-35982017000800652Revistahttps://www.rbz.org.br/pt-br/https://old.scielo.br/oai/scielo-oai.php||bz@sbz.org.br|| secretariarbz@sbz.org.br1806-92901516-3598opendoar:2017-10-11T00:00Revista Brasileira de Zootecnia (Online) - Sociedade Brasileira de Zootecnia (SBZ)false
dc.title.none.fl_str_mv Effects of tin caulis dendrobium polysaccharide on the prevention of non-alcoholic fatty liver disease in rats
title Effects of tin caulis dendrobium polysaccharide on the prevention of non-alcoholic fatty liver disease in rats
spellingShingle Effects of tin caulis dendrobium polysaccharide on the prevention of non-alcoholic fatty liver disease in rats
Xu,Dingting
fatty liver
high-fat diet
intervention
mechanisms
title_short Effects of tin caulis dendrobium polysaccharide on the prevention of non-alcoholic fatty liver disease in rats
title_full Effects of tin caulis dendrobium polysaccharide on the prevention of non-alcoholic fatty liver disease in rats
title_fullStr Effects of tin caulis dendrobium polysaccharide on the prevention of non-alcoholic fatty liver disease in rats
title_full_unstemmed Effects of tin caulis dendrobium polysaccharide on the prevention of non-alcoholic fatty liver disease in rats
title_sort Effects of tin caulis dendrobium polysaccharide on the prevention of non-alcoholic fatty liver disease in rats
author Xu,Dingting
author_facet Xu,Dingting
Zhang,Hanyun
Wang,Xiaoying
author_role author
author2 Zhang,Hanyun
Wang,Xiaoying
author2_role author
author
dc.contributor.author.fl_str_mv Xu,Dingting
Zhang,Hanyun
Wang,Xiaoying
dc.subject.por.fl_str_mv fatty liver
high-fat diet
intervention
mechanisms
topic fatty liver
high-fat diet
intervention
mechanisms
description ABSTRACT We aimed to investigate the effects and mechanisms of tin caulis dendrobium polysaccharide on body weight and non-alcoholic fatty liver disease in Sprague-Dawleg rats. The rats were fed a high-fat diet (HFD) with or without tin caulis dendrobium polysaccharide for eight weeks. Body weight, liver function tests, serum and liver lipids, liver morphology, and the expression of PPARγ and UCP2 were assessed. Rats fed HFD exhibited more obvious weight gain, increased serum, and hepatic lipids. But the more tin caulis dendrobium polysaccharide they fed, the lower increase in weight, serum, and hepatic lipids of rats were found. Furthermore, the expression of PPARγ and UCP2 decreased in rats fed tin caulis dendrobium polysaccharide compared with HFD-fed rats. Tin caulis dendrobium polysaccharide may downregulate the expression of PPARγ and UCP2 in liver and protect against body weight gain and liver fat deposition.
publishDate 2017
dc.date.none.fl_str_mv 2017-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-35982017000800652
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-35982017000800652
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/s1806-92902017000800004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Zootecnia
publisher.none.fl_str_mv Sociedade Brasileira de Zootecnia
dc.source.none.fl_str_mv Revista Brasileira de Zootecnia v.46 n.8 2017
reponame:Revista Brasileira de Zootecnia (Online)
instname:Sociedade Brasileira de Zootecnia (SBZ)
instacron:SBZ
instname_str Sociedade Brasileira de Zootecnia (SBZ)
instacron_str SBZ
institution SBZ
reponame_str Revista Brasileira de Zootecnia (Online)
collection Revista Brasileira de Zootecnia (Online)
repository.name.fl_str_mv Revista Brasileira de Zootecnia (Online) - Sociedade Brasileira de Zootecnia (SBZ)
repository.mail.fl_str_mv ||bz@sbz.org.br|| secretariarbz@sbz.org.br
_version_ 1750318152350171136

Registros relacionados