Determinants of endothelial dysfunction in noncritically ill hospitalized COVID-19 patients: a cross-sectional study
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Conjunto de dados |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFSCAR |
Texto Completo: | https://doi.org/10.1002/oby.23311 https://repositorio.ufscar.br/handle/ufscar/15570 |
Resumo: | Objective: The aim of this study was to identify determinants of endothelial dysfunction in patients hospitalized with acute COVID-19. Methods: A total of 109 hospitalized COVID-19 patients in noncritical status were cross-sectionally studied. Clinical data (age, sex, comorbidities, and medications) and BMI were assessed. Laboratory tests included serum hemoglobin, leukocytes, lymphocytes, platelets, C-reactive protein, ferritin, D-dimer, and creatinine. Physical status was evaluated using a handgrip dynamometer. Endothelial function was assessed noninvasively using the flow-mediated dilation (FMD) method. Results: The sample average age was 51 years, 51% of patients were male, and the most frequent comorbidity was obesity (62%). Univariate analysis showed association of lower FMD with higher BMI, hypertension, use of oral antihypertensive, higher blood levels of creatinine, and larger baseline artery diameter. After adjusting for confounders, the multivariate analysis showed BMI (95% CI: −0.26 to −0.11; p < 0.001) as the major factor associated with FMD. Other factors associated with FMD were baseline artery diameter (95% CI: −1.77 to −0.29; p = 0.007) and blood levels of creatinine (95% CI: −1.99 to −0.16; p = 0.022). Conclusions: Increased BMI was the major factor associated with endothelial dysfunction in noncritically hospitalized COVID-19 patients. This may explain one of the pathways in which obesity may increase the risk for severe COVID-19. |
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Heubel, Alessandro DominguesViana, Ariane AparecidaLinares, Stephanie NogueiraAmaral, Vanessa Teixeira doSchafauser, Nathany SouzaOliveira, Gustavo Yudi Orikassa deRamírez, Paula CamilaMartinelli, BrunoAlexandre, Tiago da SilvaSilva, Audrey BorghiCiolac, Emmanuel GomesMendes, Renata Gonçalveshttp://lattes.cnpq.br/0268406461810882http://lattes.cnpq.br/1481298729632703http://lattes.cnpq.br/4807021719144918http://lattes.cnpq.br/1062630392712013http://lattes.cnpq.br/5075933151971198http://lattes.cnpq.br/7445487787814347http://lattes.cnpq.br/9108932694410237http://lattes.cnpq.br/7026690603304796http://lattes.cnpq.br/5393622641681701http://lattes.cnpq.br/4855616925791895http://lattes.cnpq.br/0323573809193832http://lattes.cnpq.br/96345909222420525e9eb941-f5e6-4465-842e-9ed8f5b1a45fe3028461-2a20-40a7-8e17-9c5e269134fe0c75ccd9-5f1c-49af-a00f-5b2720a253a3abbb646a-80e2-42c3-bbff-1b7b727cc1ec1a63ccf3-c551-4b60-b267-50f51176678f79ee8118-e483-473a-9a7e-cb443e1d1a3b9022c4d7-a67e-4eff-a675-122d5cdf8ab22919c351-91b2-40d5-bfbb-19c2b874a64d30231575-e34a-4fff-a15f-6c2706a394c7223468fb-3ac6-44de-8f8a-d0ff9e395bd07fbd5a18-02ad-45a8-9208-4e9e2fe3dcbcda66150a-7d7a-490b-8123-0ee997a3c4332022-02-09T10:19:21Z2022-02-09T10:19:21Z2021-11-23https://doi.org/10.1002/oby.23311HEUBEL, Alessandro Domingues; VIANA, Ariane Aparecida; LINARES, Stephanie Nogueira; AMARAL, Vanessa Teixeira do; SCHAFAUSER, Nathany Souza; OLIVEIRA, Gustavo Yudi Orikassa de; RAMÍREZ, Paula Camila; MARTINELLI, Bruno; ALEXANDRE, Tiago da Silva; SILVA, Audrey Borghi; CIOLAC, Emmanuel Gomes; MENDES, Renata Gonçalves. Determinants of endothelial dysfunction in noncritically ill hospitalized COVID-19 patients: a cross-sectional study. Repositório Institucional da UFSCar, 2021. Dataset. Disponível em: https://repositorio.ufscar.br/handle/ufscar/15570.https://repositorio.ufscar.br/handle/ufscar/15570Objective: The aim of this study was to identify determinants of endothelial dysfunction in patients hospitalized with acute COVID-19. Methods: A total of 109 hospitalized COVID-19 patients in noncritical status were cross-sectionally studied. Clinical data (age, sex, comorbidities, and medications) and BMI were assessed. Laboratory tests included serum hemoglobin, leukocytes, lymphocytes, platelets, C-reactive protein, ferritin, D-dimer, and creatinine. Physical status was evaluated using a handgrip dynamometer. Endothelial function was assessed noninvasively using the flow-mediated dilation (FMD) method. Results: The sample average age was 51 years, 51% of patients were male, and the most frequent comorbidity was obesity (62%). Univariate analysis showed association of lower FMD with higher BMI, hypertension, use of oral antihypertensive, higher blood levels of creatinine, and larger baseline artery diameter. After adjusting for confounders, the multivariate analysis showed BMI (95% CI: −0.26 to −0.11; p < 0.001) as the major factor associated with FMD. Other factors associated with FMD were baseline artery diameter (95% CI: −1.77 to −0.29; p = 0.007) and blood levels of creatinine (95% CI: −1.99 to −0.16; p = 0.022). Conclusions: Increased BMI was the major factor associated with endothelial dysfunction in noncritically hospitalized COVID-19 patients. This may explain one of the pathways in which obesity may increase the risk for severe COVID-19.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Código de Financiamento 001 - CAPESProcesso nº 2015/09259‐2, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Processo nº 2015/26501‐1, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Processo nº 303399/2018‐0 - Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)engUniversidade Federal de São CarlosCâmpus São CarlosPrograma de Pós-Graduação em Fisioterapia - PPGFtUFSCarDepartamento de Fisioterapia - DFisiohttps://pubmed.ncbi.nlm.nih.gov/34554646/600600600600600600600600600600600600Attribution-NonCommercial-NoDerivs 3.0 Brazilhttp://creativecommons.org/licenses/by-nc-nd/3.0/br/info:eu-repo/semantics/openAccessCovid-19Endothelial functionCIENCIAS DA SAUDE::FISIOTERAPIA E TERAPIA OCUPACIONALDeterminants of endothelial dysfunction in noncritically ill hospitalized COVID-19 patients: a cross-sectional studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/datasetreponame:Repositório Institucional da UFSCARinstname:Universidade Federal de São Carlos (UFSCAR)instacron:UFSCARORIGINALDeterminants of endothelial dysfunction in noncritically ill hospitalized COVID-19 patients A cross-sectional study.xlsxDeterminants of endothelial dysfunction in noncritically ill hospitalized COVID-19 patients A cross-sectional study.xlsxapplication/vnd.openxmlformats-officedocument.spreadsheetml.sheet111855https://repositorio.ufscar.br/bitstream/ufscar/15570/3/Determinants%20of%20endothelial%20dysfunction%20in%20noncritically%20ill%20hospitalized%20COVID-19%20patients%20A%20cross-sectional%20study.xlsx0fc9a1e32e22fe18e6d9ab901e4ef5abMD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8811https://repositorio.ufscar.br/bitstream/ufscar/15570/4/license_rdfe39d27027a6cc9cb039ad269a5db8e34MD54ufscar/155702023-09-18 18:32:22.535oai:repositorio.ufscar.br:ufscar/15570Repositório InstitucionalPUBhttps://repositorio.ufscar.br/oai/requestopendoar:43222023-09-18T18:32:22Repositório Institucional da UFSCAR - Universidade Federal de São Carlos (UFSCAR)false |
dc.title.eng.fl_str_mv |
Determinants of endothelial dysfunction in noncritically ill hospitalized COVID-19 patients: a cross-sectional study |
title |
Determinants of endothelial dysfunction in noncritically ill hospitalized COVID-19 patients: a cross-sectional study |
spellingShingle |
Determinants of endothelial dysfunction in noncritically ill hospitalized COVID-19 patients: a cross-sectional study Heubel, Alessandro Domingues Covid-19 Endothelial function CIENCIAS DA SAUDE::FISIOTERAPIA E TERAPIA OCUPACIONAL |
title_short |
Determinants of endothelial dysfunction in noncritically ill hospitalized COVID-19 patients: a cross-sectional study |
title_full |
Determinants of endothelial dysfunction in noncritically ill hospitalized COVID-19 patients: a cross-sectional study |
title_fullStr |
Determinants of endothelial dysfunction in noncritically ill hospitalized COVID-19 patients: a cross-sectional study |
title_full_unstemmed |
Determinants of endothelial dysfunction in noncritically ill hospitalized COVID-19 patients: a cross-sectional study |
title_sort |
Determinants of endothelial dysfunction in noncritically ill hospitalized COVID-19 patients: a cross-sectional study |
author |
Heubel, Alessandro Domingues |
author_facet |
Heubel, Alessandro Domingues Viana, Ariane Aparecida Linares, Stephanie Nogueira Amaral, Vanessa Teixeira do Schafauser, Nathany Souza Oliveira, Gustavo Yudi Orikassa de Ramírez, Paula Camila Martinelli, Bruno Alexandre, Tiago da Silva Silva, Audrey Borghi Ciolac, Emmanuel Gomes Mendes, Renata Gonçalves |
author_role |
author |
author2 |
Viana, Ariane Aparecida Linares, Stephanie Nogueira Amaral, Vanessa Teixeira do Schafauser, Nathany Souza Oliveira, Gustavo Yudi Orikassa de Ramírez, Paula Camila Martinelli, Bruno Alexandre, Tiago da Silva Silva, Audrey Borghi Ciolac, Emmanuel Gomes Mendes, Renata Gonçalves |
author2_role |
author author author author author author author author author author author |
dc.contributor.authorlattes.por.fl_str_mv |
http://lattes.cnpq.br/0268406461810882 http://lattes.cnpq.br/1481298729632703 http://lattes.cnpq.br/4807021719144918 http://lattes.cnpq.br/1062630392712013 http://lattes.cnpq.br/5075933151971198 http://lattes.cnpq.br/7445487787814347 http://lattes.cnpq.br/9108932694410237 http://lattes.cnpq.br/7026690603304796 http://lattes.cnpq.br/5393622641681701 http://lattes.cnpq.br/4855616925791895 http://lattes.cnpq.br/0323573809193832 http://lattes.cnpq.br/9634590922242052 |
dc.contributor.author.fl_str_mv |
Heubel, Alessandro Domingues Viana, Ariane Aparecida Linares, Stephanie Nogueira Amaral, Vanessa Teixeira do Schafauser, Nathany Souza Oliveira, Gustavo Yudi Orikassa de Ramírez, Paula Camila Martinelli, Bruno Alexandre, Tiago da Silva Silva, Audrey Borghi Ciolac, Emmanuel Gomes Mendes, Renata Gonçalves |
dc.contributor.authorID.fl_str_mv |
5e9eb941-f5e6-4465-842e-9ed8f5b1a45f e3028461-2a20-40a7-8e17-9c5e269134fe 0c75ccd9-5f1c-49af-a00f-5b2720a253a3 abbb646a-80e2-42c3-bbff-1b7b727cc1ec 1a63ccf3-c551-4b60-b267-50f51176678f 79ee8118-e483-473a-9a7e-cb443e1d1a3b 9022c4d7-a67e-4eff-a675-122d5cdf8ab2 2919c351-91b2-40d5-bfbb-19c2b874a64d 30231575-e34a-4fff-a15f-6c2706a394c7 223468fb-3ac6-44de-8f8a-d0ff9e395bd0 7fbd5a18-02ad-45a8-9208-4e9e2fe3dcbc da66150a-7d7a-490b-8123-0ee997a3c433 |
dc.subject.eng.fl_str_mv |
Covid-19 Endothelial function |
topic |
Covid-19 Endothelial function CIENCIAS DA SAUDE::FISIOTERAPIA E TERAPIA OCUPACIONAL |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE::FISIOTERAPIA E TERAPIA OCUPACIONAL |
description |
Objective: The aim of this study was to identify determinants of endothelial dysfunction in patients hospitalized with acute COVID-19. Methods: A total of 109 hospitalized COVID-19 patients in noncritical status were cross-sectionally studied. Clinical data (age, sex, comorbidities, and medications) and BMI were assessed. Laboratory tests included serum hemoglobin, leukocytes, lymphocytes, platelets, C-reactive protein, ferritin, D-dimer, and creatinine. Physical status was evaluated using a handgrip dynamometer. Endothelial function was assessed noninvasively using the flow-mediated dilation (FMD) method. Results: The sample average age was 51 years, 51% of patients were male, and the most frequent comorbidity was obesity (62%). Univariate analysis showed association of lower FMD with higher BMI, hypertension, use of oral antihypertensive, higher blood levels of creatinine, and larger baseline artery diameter. After adjusting for confounders, the multivariate analysis showed BMI (95% CI: −0.26 to −0.11; p < 0.001) as the major factor associated with FMD. Other factors associated with FMD were baseline artery diameter (95% CI: −1.77 to −0.29; p = 0.007) and blood levels of creatinine (95% CI: −1.99 to −0.16; p = 0.022). Conclusions: Increased BMI was the major factor associated with endothelial dysfunction in noncritically hospitalized COVID-19 patients. This may explain one of the pathways in which obesity may increase the risk for severe COVID-19. |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021-11-23 |
dc.date.accessioned.fl_str_mv |
2022-02-09T10:19:21Z |
dc.date.available.fl_str_mv |
2022-02-09T10:19:21Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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dataset |
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https://doi.org/10.1002/oby.23311 |
dc.identifier.citation.fl_str_mv |
HEUBEL, Alessandro Domingues; VIANA, Ariane Aparecida; LINARES, Stephanie Nogueira; AMARAL, Vanessa Teixeira do; SCHAFAUSER, Nathany Souza; OLIVEIRA, Gustavo Yudi Orikassa de; RAMÍREZ, Paula Camila; MARTINELLI, Bruno; ALEXANDRE, Tiago da Silva; SILVA, Audrey Borghi; CIOLAC, Emmanuel Gomes; MENDES, Renata Gonçalves. Determinants of endothelial dysfunction in noncritically ill hospitalized COVID-19 patients: a cross-sectional study. Repositório Institucional da UFSCar, 2021. Dataset. Disponível em: https://repositorio.ufscar.br/handle/ufscar/15570. |
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https://repositorio.ufscar.br/handle/ufscar/15570 |
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https://doi.org/10.1002/oby.23311 https://repositorio.ufscar.br/handle/ufscar/15570 |
identifier_str_mv |
HEUBEL, Alessandro Domingues; VIANA, Ariane Aparecida; LINARES, Stephanie Nogueira; AMARAL, Vanessa Teixeira do; SCHAFAUSER, Nathany Souza; OLIVEIRA, Gustavo Yudi Orikassa de; RAMÍREZ, Paula Camila; MARTINELLI, Bruno; ALEXANDRE, Tiago da Silva; SILVA, Audrey Borghi; CIOLAC, Emmanuel Gomes; MENDES, Renata Gonçalves. Determinants of endothelial dysfunction in noncritically ill hospitalized COVID-19 patients: a cross-sectional study. Repositório Institucional da UFSCar, 2021. Dataset. Disponível em: https://repositorio.ufscar.br/handle/ufscar/15570. |
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eng |
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eng |
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600 600 600 600 600 600 600 600 600 600 600 600 |
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https://pubmed.ncbi.nlm.nih.gov/34554646/ |
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Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ info:eu-repo/semantics/openAccess |
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Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ |
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openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de São Carlos Câmpus São Carlos |
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Programa de Pós-Graduação em Fisioterapia - PPGFt |
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UFSCar |
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Departamento de Fisioterapia - DFisio |
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Universidade Federal de São Carlos Câmpus São Carlos |
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