Factors related to survival in Intensive Care Unit patients with Covid-19: a study from a single center in Brazil
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | preprint |
Idioma: | eng |
Título da fonte: | SciELO Preprints |
Texto Completo: | https://preprints.scielo.org/index.php/scielo/preprint/view/4453 |
Resumo: | Introduction: Analysis of the outcome of 268 ICU patients in a single-center, as well the impact of viral infection on patients with preexisting medical conditions and how these factors affected survival and hospital stay. Methodology: Patients admitted to the ICU from March-August, 2020 were retrospectively analyzed under the same protocol at Hospital Alemão Oswaldo Cruz, São Paulo, Brazil. Several factors were considered and the results were presented using 95% confidence intervals. For statistical significance, p <0.05 was adopted. Results: Patient median age was 72 years, 64,2 years for discharged patients and 79.9 years for those deceased (p<0.001). The most common comorbidities were: systemic arterial hypertension, diabetes, thyroid disease, cardiovascular and kidney disease. Predictors of survival through univariate analysis: myalgia (p=0.001), cerebrovascular disease (p=0.002), COPD (p=0.003), dementia (p=0.000), mechanical ventilation (p=0.000), dialysis (0.000), vasopressor use (0.000), SAPS3 (0.000), lymphopenia (p=0.004), elevated D-dimer (P=0.011), time in ICU before tracheostomy (p=0.002), and performing a tracheostomy (p=0.000). The independent predictors of mortality were: advanced age (p=0.003) and tracheostomy performed in ICU (p=0.002). Discussion: COVID-19 affects usually older adults, where there already is a higher fatality rate. Acute respiratory distress syndrome is the primary cause of death and <5% of patients were reported as experiencing co-infection at admission. Conclusion: age, vasopressor use in patients with tracheostomy, and systemic coronary disease, heart failure, neoplasia, and COPD, were found to be significantly associated with COVID-19 severity. |
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Factors related to survival in Intensive Care Unit patients with Covid-19: a study from a single center in BrazilCoronavirusCOVID-19 pandemicIntensive care unitComorbidityIntroduction: Analysis of the outcome of 268 ICU patients in a single-center, as well the impact of viral infection on patients with preexisting medical conditions and how these factors affected survival and hospital stay. Methodology: Patients admitted to the ICU from March-August, 2020 were retrospectively analyzed under the same protocol at Hospital Alemão Oswaldo Cruz, São Paulo, Brazil. Several factors were considered and the results were presented using 95% confidence intervals. For statistical significance, p <0.05 was adopted. Results: Patient median age was 72 years, 64,2 years for discharged patients and 79.9 years for those deceased (p<0.001). The most common comorbidities were: systemic arterial hypertension, diabetes, thyroid disease, cardiovascular and kidney disease. Predictors of survival through univariate analysis: myalgia (p=0.001), cerebrovascular disease (p=0.002), COPD (p=0.003), dementia (p=0.000), mechanical ventilation (p=0.000), dialysis (0.000), vasopressor use (0.000), SAPS3 (0.000), lymphopenia (p=0.004), elevated D-dimer (P=0.011), time in ICU before tracheostomy (p=0.002), and performing a tracheostomy (p=0.000). The independent predictors of mortality were: advanced age (p=0.003) and tracheostomy performed in ICU (p=0.002). Discussion: COVID-19 affects usually older adults, where there already is a higher fatality rate. Acute respiratory distress syndrome is the primary cause of death and <5% of patients were reported as experiencing co-infection at admission. Conclusion: age, vasopressor use in patients with tracheostomy, and systemic coronary disease, heart failure, neoplasia, and COPD, were found to be significantly associated with COVID-19 severity.SciELO PreprintsSciELO PreprintsSciELO Preprints2022-07-21info:eu-repo/semantics/preprintinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://preprints.scielo.org/index.php/scielo/preprint/view/445310.1590/SciELOPreprints.4453enghttps://preprints.scielo.org/index.php/scielo/article/view/4453/8508Copyright (c) 2022 Rodrigo A. S. Sardenberg, Gabriel Antonio Roberto, Catarina Marchon da Silva, Andrea Santos Galvão, Daniela Jesus Meireles Ribeiro Pinho, Tabatta Zambotto Sachelli, Gabriela Bezerra Freitas Dinizhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSardenberg, Rodrigo A. S.Roberto, Gabriel AntonioSilva, Catarina Marchon daGalvão, Andrea SantosPinho, Daniela Jesus Meireles RibeiroSachelli, Tabatta ZambottoDiniz, Gabriela Bezerra Freitasreponame:SciELO Preprintsinstname:SciELOinstacron:SCI2022-07-17T15:21:14Zoai:ops.preprints.scielo.org:preprint/4453Servidor de preprintshttps://preprints.scielo.org/index.php/scieloONGhttps://preprints.scielo.org/index.php/scielo/oaiscielo.submission@scielo.orgopendoar:2022-07-17T15:21:14SciELO Preprints - SciELOfalse |
dc.title.none.fl_str_mv |
Factors related to survival in Intensive Care Unit patients with Covid-19: a study from a single center in Brazil |
title |
Factors related to survival in Intensive Care Unit patients with Covid-19: a study from a single center in Brazil |
spellingShingle |
Factors related to survival in Intensive Care Unit patients with Covid-19: a study from a single center in Brazil Sardenberg, Rodrigo A. S. Coronavirus COVID-19 pandemic Intensive care unit Comorbidity |
title_short |
Factors related to survival in Intensive Care Unit patients with Covid-19: a study from a single center in Brazil |
title_full |
Factors related to survival in Intensive Care Unit patients with Covid-19: a study from a single center in Brazil |
title_fullStr |
Factors related to survival in Intensive Care Unit patients with Covid-19: a study from a single center in Brazil |
title_full_unstemmed |
Factors related to survival in Intensive Care Unit patients with Covid-19: a study from a single center in Brazil |
title_sort |
Factors related to survival in Intensive Care Unit patients with Covid-19: a study from a single center in Brazil |
author |
Sardenberg, Rodrigo A. S. |
author_facet |
Sardenberg, Rodrigo A. S. Roberto, Gabriel Antonio Silva, Catarina Marchon da Galvão, Andrea Santos Pinho, Daniela Jesus Meireles Ribeiro Sachelli, Tabatta Zambotto Diniz, Gabriela Bezerra Freitas |
author_role |
author |
author2 |
Roberto, Gabriel Antonio Silva, Catarina Marchon da Galvão, Andrea Santos Pinho, Daniela Jesus Meireles Ribeiro Sachelli, Tabatta Zambotto Diniz, Gabriela Bezerra Freitas |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Sardenberg, Rodrigo A. S. Roberto, Gabriel Antonio Silva, Catarina Marchon da Galvão, Andrea Santos Pinho, Daniela Jesus Meireles Ribeiro Sachelli, Tabatta Zambotto Diniz, Gabriela Bezerra Freitas |
dc.subject.por.fl_str_mv |
Coronavirus COVID-19 pandemic Intensive care unit Comorbidity |
topic |
Coronavirus COVID-19 pandemic Intensive care unit Comorbidity |
description |
Introduction: Analysis of the outcome of 268 ICU patients in a single-center, as well the impact of viral infection on patients with preexisting medical conditions and how these factors affected survival and hospital stay. Methodology: Patients admitted to the ICU from March-August, 2020 were retrospectively analyzed under the same protocol at Hospital Alemão Oswaldo Cruz, São Paulo, Brazil. Several factors were considered and the results were presented using 95% confidence intervals. For statistical significance, p <0.05 was adopted. Results: Patient median age was 72 years, 64,2 years for discharged patients and 79.9 years for those deceased (p<0.001). The most common comorbidities were: systemic arterial hypertension, diabetes, thyroid disease, cardiovascular and kidney disease. Predictors of survival through univariate analysis: myalgia (p=0.001), cerebrovascular disease (p=0.002), COPD (p=0.003), dementia (p=0.000), mechanical ventilation (p=0.000), dialysis (0.000), vasopressor use (0.000), SAPS3 (0.000), lymphopenia (p=0.004), elevated D-dimer (P=0.011), time in ICU before tracheostomy (p=0.002), and performing a tracheostomy (p=0.000). The independent predictors of mortality were: advanced age (p=0.003) and tracheostomy performed in ICU (p=0.002). Discussion: COVID-19 affects usually older adults, where there already is a higher fatality rate. Acute respiratory distress syndrome is the primary cause of death and <5% of patients were reported as experiencing co-infection at admission. Conclusion: age, vasopressor use in patients with tracheostomy, and systemic coronary disease, heart failure, neoplasia, and COPD, were found to be significantly associated with COVID-19 severity. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-07-21 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/preprint info:eu-repo/semantics/publishedVersion |
format |
preprint |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
https://preprints.scielo.org/index.php/scielo/preprint/view/4453 10.1590/SciELOPreprints.4453 |
url |
https://preprints.scielo.org/index.php/scielo/preprint/view/4453 |
identifier_str_mv |
10.1590/SciELOPreprints.4453 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://preprints.scielo.org/index.php/scielo/article/view/4453/8508 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
SciELO Preprints SciELO Preprints SciELO Preprints |
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SciELO Preprints SciELO Preprints SciELO Preprints |
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reponame:SciELO Preprints instname:SciELO instacron:SCI |
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SciELO |
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SciELO Preprints - SciELO |
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