Tumor stem cells markers characterization in squamous cell carcinoma of oral cavity

Detalhes bibliográficos
Autor(a) principal: Garcia, Manuel
Data de Publicação: 2021
Outros Autores: Campuzano, Marisol
Tipo de documento: preprint
Idioma: spa
Título da fonte: SciELO Preprints
Texto Completo: https://preprints.scielo.org/index.php/scielo/preprint/view/1848
Resumo: Squamous cell cancer of the oral cavity is a pathology with low survival rates for patients who suffer from it. It is suggested that this may be a consequence of its recurrence and resistance to treatment. It has been suggested that progenitor tumor cells due to their self-renewal, tumor initiation, migration and metastasis properties may be responsible for the maintenance and renewal of the tumor. However, there is still no consensus on the true participation of these cells and their identification and characterization is still an experimental challenge. In this study, it was possible to identify in situ, using fluorescence microscopy, different markers of progenitor tumor cells: Tumour-Related Antigen [TRA] -1-60, Stage- Specific Embryonic Antigen-4 [SSEA-4], SOX2, NANOG and OCT4, The presence of these markers suggests the participation of tumor progenitor cells in the evolution of this type of cancer, which opens up new therapeutic avenues for the possible treatment of this tumor in order to improve prognosis, survival rate and quality of life of the patient
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spelling Tumor stem cells markers characterization in squamous cell carcinoma of oral cavityCaracterización de Marcadores de Células Madre Tumorales en Cáncer Escamocelular de Cavidad OralCaracterizacao de marcadores de células progenitoras no carcinoma escamoso de cavidade oral Carcinoma Escamoso de Cavidade OralMarcadores de Células ProgenitorasBiomarcadoresSquamous Cell Carcinoma of Head and NeckEmbryonal Carcinoma Stem CellsBiomarkersTumorCarcinoma Escamocelular de Cabeza y CuelloCélulas Tumorales ProgenitorasBiomarcadores TumoralesSquamous cell cancer of the oral cavity is a pathology with low survival rates for patients who suffer from it. It is suggested that this may be a consequence of its recurrence and resistance to treatment. It has been suggested that progenitor tumor cells due to their self-renewal, tumor initiation, migration and metastasis properties may be responsible for the maintenance and renewal of the tumor. However, there is still no consensus on the true participation of these cells and their identification and characterization is still an experimental challenge. In this study, it was possible to identify in situ, using fluorescence microscopy, different markers of progenitor tumor cells: Tumour-Related Antigen [TRA] -1-60, Stage- Specific Embryonic Antigen-4 [SSEA-4], SOX2, NANOG and OCT4, The presence of these markers suggests the participation of tumor progenitor cells in the evolution of this type of cancer, which opens up new therapeutic avenues for the possible treatment of this tumor in order to improve prognosis, survival rate and quality of life of the patient El cancer escamocelular de cavidad oral es una patología con bajas tasas de sobrevivencia para los pacientes que lo padecen. Se plantea que esto puede ser consecuencia de su recurrencia y resistencia al tratamiento. Se ha planteado que las células tumorales progenitoras por sus propiedades de auto renovación, iniciación tumoral, migración y metástasis pueden ser lasresponsables de la manutención y renovación del tumor. Sin embargo, aun no existe un consenso sobre la verdadera participación de estas células y su identificación y caracterización es aun un reto experimental. En este estudio se lograron identificar in situ, mediante microscopia defluorescencia, diferentes marcadores de células tumorales progenitoras: Tumour-Related Antigen [TRA]-1-60, Stage-Specific Embryonic Antigen-4 [SSEA-4], SOX2, NANOG y OCT4, La presencia de estos marcadores sugiere la participación de las célulasprogenitoras tumorales en la evolución de este tipo de cáncer, lo que abre nuevas vías terapéuticas para el posible tratamiento de este tumor con el fin de mejorar el pronostico, tasa de sobrevivencia y calidad de vida del paciente. SciELO PreprintsSciELO PreprintsSciELO Preprints2021-02-18info:eu-repo/semantics/preprintinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://preprints.scielo.org/index.php/scielo/preprint/view/184810.1590/SciELOPreprints.1848spahttps://preprints.scielo.org/index.php/scielo/article/view/1848/2966Copyright (c) 2021 Manuel Garcia, Marisol Campuzanohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessGarcia, ManuelCampuzano, Marisol reponame:SciELO Preprintsinstname:SciELOinstacron:SCI2021-02-12T00:00:44Zoai:ops.preprints.scielo.org:preprint/1848Servidor de preprintshttps://preprints.scielo.org/index.php/scieloONGhttps://preprints.scielo.org/index.php/scielo/oaiscielo.submission@scielo.orgopendoar:2021-02-12T00:00:44SciELO Preprints - SciELOfalse
dc.title.none.fl_str_mv Tumor stem cells markers characterization in squamous cell carcinoma of oral cavity
Caracterización de Marcadores de Células Madre Tumorales en Cáncer Escamocelular de Cavidad Oral
Caracterizacao de marcadores de células progenitoras no carcinoma escamoso de cavidade oral
title Tumor stem cells markers characterization in squamous cell carcinoma of oral cavity
spellingShingle Tumor stem cells markers characterization in squamous cell carcinoma of oral cavity
Garcia, Manuel
Carcinoma Escamoso de Cavidade Oral
Marcadores de Células Progenitoras
Biomarcadores
Squamous Cell Carcinoma of Head and Neck
Embryonal Carcinoma Stem Cells
Biomarkers
Tumor
Carcinoma Escamocelular de Cabeza y Cuello
Células Tumorales Progenitoras
Biomarcadores Tumorales
title_short Tumor stem cells markers characterization in squamous cell carcinoma of oral cavity
title_full Tumor stem cells markers characterization in squamous cell carcinoma of oral cavity
title_fullStr Tumor stem cells markers characterization in squamous cell carcinoma of oral cavity
title_full_unstemmed Tumor stem cells markers characterization in squamous cell carcinoma of oral cavity
title_sort Tumor stem cells markers characterization in squamous cell carcinoma of oral cavity
author Garcia, Manuel
author_facet Garcia, Manuel
Campuzano, Marisol
author_role author
author2 Campuzano, Marisol
author2_role author
dc.contributor.author.fl_str_mv Garcia, Manuel
Campuzano, Marisol
dc.subject.por.fl_str_mv Carcinoma Escamoso de Cavidade Oral
Marcadores de Células Progenitoras
Biomarcadores
Squamous Cell Carcinoma of Head and Neck
Embryonal Carcinoma Stem Cells
Biomarkers
Tumor
Carcinoma Escamocelular de Cabeza y Cuello
Células Tumorales Progenitoras
Biomarcadores Tumorales
topic Carcinoma Escamoso de Cavidade Oral
Marcadores de Células Progenitoras
Biomarcadores
Squamous Cell Carcinoma of Head and Neck
Embryonal Carcinoma Stem Cells
Biomarkers
Tumor
Carcinoma Escamocelular de Cabeza y Cuello
Células Tumorales Progenitoras
Biomarcadores Tumorales
description Squamous cell cancer of the oral cavity is a pathology with low survival rates for patients who suffer from it. It is suggested that this may be a consequence of its recurrence and resistance to treatment. It has been suggested that progenitor tumor cells due to their self-renewal, tumor initiation, migration and metastasis properties may be responsible for the maintenance and renewal of the tumor. However, there is still no consensus on the true participation of these cells and their identification and characterization is still an experimental challenge. In this study, it was possible to identify in situ, using fluorescence microscopy, different markers of progenitor tumor cells: Tumour-Related Antigen [TRA] -1-60, Stage- Specific Embryonic Antigen-4 [SSEA-4], SOX2, NANOG and OCT4, The presence of these markers suggests the participation of tumor progenitor cells in the evolution of this type of cancer, which opens up new therapeutic avenues for the possible treatment of this tumor in order to improve prognosis, survival rate and quality of life of the patient
publishDate 2021
dc.date.none.fl_str_mv 2021-02-18
dc.type.driver.fl_str_mv info:eu-repo/semantics/preprint
info:eu-repo/semantics/publishedVersion
format preprint
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://preprints.scielo.org/index.php/scielo/preprint/view/1848
10.1590/SciELOPreprints.1848
url https://preprints.scielo.org/index.php/scielo/preprint/view/1848
identifier_str_mv 10.1590/SciELOPreprints.1848
dc.language.iso.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv https://preprints.scielo.org/index.php/scielo/article/view/1848/2966
dc.rights.driver.fl_str_mv Copyright (c) 2021 Manuel Garcia, Marisol Campuzano
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2021 Manuel Garcia, Marisol Campuzano
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv SciELO Preprints
SciELO Preprints
SciELO Preprints
publisher.none.fl_str_mv SciELO Preprints
SciELO Preprints
SciELO Preprints
dc.source.none.fl_str_mv reponame:SciELO Preprints
instname:SciELO
instacron:SCI
instname_str SciELO
instacron_str SCI
institution SCI
reponame_str SciELO Preprints
collection SciELO Preprints
repository.name.fl_str_mv SciELO Preprints - SciELO
repository.mail.fl_str_mv scielo.submission@scielo.org
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