ROLE OF AUTOPHAGY IN THE ETIOPATHOGENESIS OF ORAL CANCER. SCOPING REVIEW

Detalhes bibliográficos
Autor(a) principal: López, Francisca
Data de Publicação: 2022
Outros Autores: Moreno, Arelys, Reyes, Silvana, Sánchez, Marcelo
Tipo de documento: preprint
Idioma: spa
Título da fonte: SciELO Preprints
Texto Completo: https://preprints.scielo.org/index.php/scielo/preprint/view/5094
Resumo: In this exploratory systematic review, we present the evidence recorded in the literature, that autophagy can generate both a procancer and anticancer action, acting through various mechanisms in which the autophagy process can be increased, decreased, or altered, through the activation of intracellular signaling pathways. Currently, there is sufficient evidence to support the association between autophagy and different types of cancer, however, there is no review that brings together the various mechanisms by which the autophagic process participates in its development and/or suppression. It was possible to show that there are various mechanisms by which autophagy participates in the development of oral carcinogenesis, influencing both the inhibition and the production of cancer. It is of great importance to increase the knowledge about this process because it could be used as a valuable tool in the treatment of this disease.
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spelling ROLE OF AUTOPHAGY IN THE ETIOPATHOGENESIS OF ORAL CANCER. SCOPING REVIEWROL DE LA AUTOFAGIA EN LA ETIOPATOGÉNESIS DEL CÁNCER ORAL. REVISIÓN SISTEMÁTICA EXPLORATORIAPAPEL DA AUTOFAGIA NA ETIOPATOGÊNESE DO CÂNCER ORAL. REVISÃO SISTEMÁTICA EXPLORATÓRIAAutofagiaNeoplasias de la bocaCarcinogénesisCarcinoma Escamo Celular de Cabeza y CuelloAutophagyNeoplasms of the mouthCarcinogenesisSquamous Cell Carcinoma of the Head and NeckAutofagiaNeoplasias de la bocaCarcinogénesisCarcinoma Escamo Celular de Cabeza y CuelloIn this exploratory systematic review, we present the evidence recorded in the literature, that autophagy can generate both a procancer and anticancer action, acting through various mechanisms in which the autophagy process can be increased, decreased, or altered, through the activation of intracellular signaling pathways. Currently, there is sufficient evidence to support the association between autophagy and different types of cancer, however, there is no review that brings together the various mechanisms by which the autophagic process participates in its development and/or suppression. It was possible to show that there are various mechanisms by which autophagy participates in the development of oral carcinogenesis, influencing both the inhibition and the production of cancer. It is of great importance to increase the knowledge about this process because it could be used as a valuable tool in the treatment of this disease.En esta revisión sistemática exploratoria, presentamos la evidencia registrada en la literatura, de que la autofagia puede generar una acción tanto procáncer como anticáncer, actuando a través de diversos mecanismos en los cuales el proceso de autofagia puede estar aumentado, disminuido o alterado, mediante la activación de vías de señalización intracelular. En la actualidad, hay evidencia suficiente que avala la asociación entre autofagia y distintos tipos de cáncer, sin embargo, no hay una revisión que reúna los diversos mecanismos por los cuales el proceso autofágico participa en su desarrollo y/o supresión. Se logro evidenciar que existen variados mecanismos por los cuales la autofagia participa en el desarrollo de la carcinogénesis oral, influyendo tanto en la inhibición como en la producción de cáncer. Es de gran importancia aumentar el conocimiento acerca de este proceso, debido a que podría ser utilizado como una herramienta valiosa en el tratamiento de esta enfermedad.Nesta revisão exploratória sistemática, apresentamos as evidências registradas na literatura, de que a autofagia pode gerar ação tanto procancer quanto anticancerígena, atuando por meio de diversos mecanismos nos quais o processo de autofagia pode ser aumentado, diminuído ou alterado, por meio da ativação de vias de sinalização intracelular . Na atualidade, há evidências suficientes de que há associação entre autofagia e diferentes tipos de câncer, sem embargo, não há uma revisão que reúna os diversos mecanismos por meio dos quais o processo autofágico participa de seu desenvolvimento e/ou supressão. Se logro evidenciar que existem vários mecanismos pelos quais a autofagia participa no desenvolvimento da carcinogênese oral, influenciando tanto na inibição como na produção de câncer. É de grande importância aumentar o conhecimento sobre este processo, devido a que poderia ser usado como um usuário avaliado no tratamento desta doença.SciELO PreprintsSciELO PreprintsSciELO Preprints2022-11-18info:eu-repo/semantics/preprintinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://preprints.scielo.org/index.php/scielo/preprint/view/509410.1590/SciELOPreprints.5094spahttps://preprints.scielo.org/index.php/scielo/article/view/5094/9894Copyright (c) 2022 Francisca López, Arelys Moreno, Silvana Reyes, Marcelo Sánchezhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessLópez, FranciscaMoreno, ArelysReyes, SilvanaSánchez, Marceloreponame:SciELO Preprintsinstname:SciELOinstacron:SCI2022-11-17T02:06:20Zoai:ops.preprints.scielo.org:preprint/5094Servidor de preprintshttps://preprints.scielo.org/index.php/scieloONGhttps://preprints.scielo.org/index.php/scielo/oaiscielo.submission@scielo.orgopendoar:2022-11-17T02:06:20SciELO Preprints - SciELOfalse
dc.title.none.fl_str_mv ROLE OF AUTOPHAGY IN THE ETIOPATHOGENESIS OF ORAL CANCER. SCOPING REVIEW
ROL DE LA AUTOFAGIA EN LA ETIOPATOGÉNESIS DEL CÁNCER ORAL. REVISIÓN SISTEMÁTICA EXPLORATORIA
PAPEL DA AUTOFAGIA NA ETIOPATOGÊNESE DO CÂNCER ORAL. REVISÃO SISTEMÁTICA EXPLORATÓRIA
title ROLE OF AUTOPHAGY IN THE ETIOPATHOGENESIS OF ORAL CANCER. SCOPING REVIEW
spellingShingle ROLE OF AUTOPHAGY IN THE ETIOPATHOGENESIS OF ORAL CANCER. SCOPING REVIEW
López, Francisca
Autofagia
Neoplasias de la boca
Carcinogénesis
Carcinoma Escamo Celular de Cabeza y Cuello
Autophagy
Neoplasms of the mouth
Carcinogenesis
Squamous Cell Carcinoma of the Head and Neck
Autofagia
Neoplasias de la boca
Carcinogénesis
Carcinoma Escamo Celular de Cabeza y Cuello
title_short ROLE OF AUTOPHAGY IN THE ETIOPATHOGENESIS OF ORAL CANCER. SCOPING REVIEW
title_full ROLE OF AUTOPHAGY IN THE ETIOPATHOGENESIS OF ORAL CANCER. SCOPING REVIEW
title_fullStr ROLE OF AUTOPHAGY IN THE ETIOPATHOGENESIS OF ORAL CANCER. SCOPING REVIEW
title_full_unstemmed ROLE OF AUTOPHAGY IN THE ETIOPATHOGENESIS OF ORAL CANCER. SCOPING REVIEW
title_sort ROLE OF AUTOPHAGY IN THE ETIOPATHOGENESIS OF ORAL CANCER. SCOPING REVIEW
author López, Francisca
author_facet López, Francisca
Moreno, Arelys
Reyes, Silvana
Sánchez, Marcelo
author_role author
author2 Moreno, Arelys
Reyes, Silvana
Sánchez, Marcelo
author2_role author
author
author
dc.contributor.author.fl_str_mv López, Francisca
Moreno, Arelys
Reyes, Silvana
Sánchez, Marcelo
dc.subject.por.fl_str_mv Autofagia
Neoplasias de la boca
Carcinogénesis
Carcinoma Escamo Celular de Cabeza y Cuello
Autophagy
Neoplasms of the mouth
Carcinogenesis
Squamous Cell Carcinoma of the Head and Neck
Autofagia
Neoplasias de la boca
Carcinogénesis
Carcinoma Escamo Celular de Cabeza y Cuello
topic Autofagia
Neoplasias de la boca
Carcinogénesis
Carcinoma Escamo Celular de Cabeza y Cuello
Autophagy
Neoplasms of the mouth
Carcinogenesis
Squamous Cell Carcinoma of the Head and Neck
Autofagia
Neoplasias de la boca
Carcinogénesis
Carcinoma Escamo Celular de Cabeza y Cuello
description In this exploratory systematic review, we present the evidence recorded in the literature, that autophagy can generate both a procancer and anticancer action, acting through various mechanisms in which the autophagy process can be increased, decreased, or altered, through the activation of intracellular signaling pathways. Currently, there is sufficient evidence to support the association between autophagy and different types of cancer, however, there is no review that brings together the various mechanisms by which the autophagic process participates in its development and/or suppression. It was possible to show that there are various mechanisms by which autophagy participates in the development of oral carcinogenesis, influencing both the inhibition and the production of cancer. It is of great importance to increase the knowledge about this process because it could be used as a valuable tool in the treatment of this disease.
publishDate 2022
dc.date.none.fl_str_mv 2022-11-18
dc.type.driver.fl_str_mv info:eu-repo/semantics/preprint
info:eu-repo/semantics/publishedVersion
format preprint
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://preprints.scielo.org/index.php/scielo/preprint/view/5094
10.1590/SciELOPreprints.5094
url https://preprints.scielo.org/index.php/scielo/preprint/view/5094
identifier_str_mv 10.1590/SciELOPreprints.5094
dc.language.iso.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv https://preprints.scielo.org/index.php/scielo/article/view/5094/9894
dc.rights.driver.fl_str_mv Copyright (c) 2022 Francisca López, Arelys Moreno, Silvana Reyes, Marcelo Sánchez
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2022 Francisca López, Arelys Moreno, Silvana Reyes, Marcelo Sánchez
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv SciELO Preprints
SciELO Preprints
SciELO Preprints
publisher.none.fl_str_mv SciELO Preprints
SciELO Preprints
SciELO Preprints
dc.source.none.fl_str_mv reponame:SciELO Preprints
instname:SciELO
instacron:SCI
instname_str SciELO
instacron_str SCI
institution SCI
reponame_str SciELO Preprints
collection SciELO Preprints
repository.name.fl_str_mv SciELO Preprints - SciELO
repository.mail.fl_str_mv scielo.submission@scielo.org
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