WHAT ARE THE CLINICAL- ENDOSCOPIC DIFFERENTIALS OF CELIAC DISEASE IN DYSPEPTIC SYNDROME?

• Autor(a) principal: Cruz, Manoela Aguiar
• Data de Publicação: 2023
• Outros Autores: Czeczko , Nicolau Gregori, Rutz, Leticia Elizabeth Augustin Czeczko, Malafaia , Matheus Toniolo
• Tipo de documento: preprint
• Idioma: por
• Título da fonte: SciELO Preprints
• Texto Completo: https://preprints.scielo.org/index.php/scielo/preprint/view/7426
• topic: Dispepsia; Doença celíaca; Glúten; Prevalência; Dyspepsia; Celiac disease; Gluten; Prevalence

Introduction: Celiac disease is an autoimmune disease related to gluten that affects the small intestine. Dyspepsia is a set of symptoms of the upper abdomen that includes epigastric burning, postprandial fullness and early satiety and has a prevalence of 10-45% of the population with different etiological possibilities, including celiac disease. Objectives: To evaluate the prevalence of celiac disease in patients with a clinical diagnosis of dyspeptic syndrome and to study the sample regarding epidemiology, symptoms, endoscopic, histological and serological findings. Method: Observational research, based on a review of medical records of patients treated for uninvestigated dyspepsia. Patients over 18 years of age, with this dyspepsia and who had endoscopy, total immunoglobulin A and IgA antitransglutaminase were included. Those with diarrhea, constipation, malabsorption, refractory lactose intolerance or who presented extraintestinal signs or symptoms suggestive of celiac disease were excluded. Results: The initial sample was 1802 records and the final 200 patients. Of these, 100 had endoscopy, histology and antibody measurement, and the remaining 100 had endoscopy and antibody measurement, but not histology. Considering the total sample, the average age was 45.13 years and the female sex was predominant. Symptoms associated with gluten were reported in 6%. The antitransglutaminase antibody was positive in 1.5%. Considering the sample of 100 patients, the diagnosis of celiac disease had a prevalence of 3%. Conclusion: The prevalence of celiac disease in patients with a clinical diagnosis of dyspeptic syndrome was 3%.