CD114 MEMBRANE RECEPTORS CAN HELP IN THE ASSESSMENT OF MOLECULAR MORTALITY IN MEDULOBLASTOMAS?

• Autor(a) principal: Monteiro, Jander Moreira
• Data de Publicação: 2023
• Outros Autores: Ramos , Jaqueline Isadora Reis, Sousa, Ian Teixeira e, Bighetti-Trevisan, Rayana Longo, Ribas-Filho, Jurandir Marcondes, Isolan, Gustavo Rassier, Nassif , Paulo Afonso Nunes, Polanski , José Fernando
• Tipo de documento: preprint
• Idioma: por
• Título da fonte: SciELO Preprints
• Texto Completo: https://preprints.scielo.org/index.php/scielo/preprint/view/7717
• topic: Neurocirurgia; Oncologia cirúrgica; Terapia de alvo molecular; Meduloblastoma; Neurosurgery; Surgical oncology; Molecular targeted therapy; Medulloblastoma

Introduction: Medulloblastomas are the most common solid tumors of childhood and many studies seek to develop new chemotherapy drugs by identifying genes whose expression is new molecular targets for drugs, such as membrane receptors associated with cell replication. Objective: To review existing knowledge about the association of CD114 expression with mortality in medulloblastoma. Method: Narrative review collecting information with material for reading and analysis selected from research on virtual platforms (SciELO, Pubmed and Scopus). Initially, a search was carried out for descriptors related to the topic, which were identified through MESH using the following terms: “neurosurgery, surgical oncology, molecular targeted therapy, medulloblastoma” with AND or OR search, considering the title and/or abstract. After, the search was carried out, the title and abstract were analyzed and those that could be included were read in full. Results: 23 articles were included. Conclusion: There is no direct relationship between the expression of the CD114 membrane receptor and mortality in patients with medulloblastoma, and additional studies should be carried out on the intracellular signaling pathways associated with this receptor and its gene, CSF3R