CD114 MEMBRANE RECEPTORS CAN HELP IN THE ASSESSMENT OF MOLECULAR MORTALITY IN MEDULOBLASTOMAS?

Detalhes bibliográficos
Autor(a) principal: Monteiro, Jander Moreira
Data de Publicação: 2023
Outros Autores: Ramos , Jaqueline Isadora Reis, Sousa, Ian Teixeira e, Bighetti-Trevisan, Rayana Longo, Ribas-Filho, Jurandir Marcondes, Isolan, Gustavo Rassier, Nassif , Paulo Afonso Nunes, Polanski , José Fernando
Tipo de documento: preprint
Idioma: por
Título da fonte: SciELO Preprints
Texto Completo: https://preprints.scielo.org/index.php/scielo/preprint/view/7717
Resumo: Introduction: Medulloblastomas are the most common solid tumors of childhood and many studies seek to develop new chemotherapy drugs by identifying genes whose expression is new molecular targets for drugs, such as membrane receptors associated with cell replication. Objective: To review existing knowledge about the association of CD114 expression with mortality in medulloblastoma. Method: Narrative review collecting information with material for reading and analysis selected from research on virtual platforms (SciELO, Pubmed and Scopus). Initially, a search was carried out for descriptors related to the topic, which were identified through MESH using the following terms: “neurosurgery, surgical oncology, molecular targeted therapy, medulloblastoma” with AND or OR search, considering the title and/or abstract. After, the search was carried out, the title and abstract were analyzed and those that could be included were read in full. Results: 23 articles were included. Conclusion: There is no direct relationship between the expression of the CD114 membrane receptor and mortality in patients with medulloblastoma, and additional studies should be carried out on the intracellular signaling pathways associated with this receptor and its gene, CSF3R
id SCI-1_847ddc46b3400af1711b6d9ace3dfa4f
oai_identifier_str oai:ops.preprints.scielo.org:preprint/7717
network_acronym_str SCI-1
network_name_str SciELO Preprints
repository_id_str
spelling CD114 MEMBRANE RECEPTORS CAN HELP IN THE ASSESSMENT OF MOLECULAR MORTALITY IN MEDULOBLASTOMAS?RECEPTORES DE MEMBRANA CD114 PODEM AUXILIAR NA AVALIAÇÃO DA MORTALIDADE MOLECULAR EM MEDULOBLASTOMAS?NeurocirurgiaOncologia cirúrgicaTerapia de alvo molecularMeduloblastomaNeurosurgerySurgical oncologyMolecular targeted therapyMedulloblastomaIntroduction: Medulloblastomas are the most common solid tumors of childhood and many studies seek to develop new chemotherapy drugs by identifying genes whose expression is new molecular targets for drugs, such as membrane receptors associated with cell replication. Objective: To review existing knowledge about the association of CD114 expression with mortality in medulloblastoma. Method: Narrative review collecting information with material for reading and analysis selected from research on virtual platforms (SciELO, Pubmed and Scopus). Initially, a search was carried out for descriptors related to the topic, which were identified through MESH using the following terms: “neurosurgery, surgical oncology, molecular targeted therapy, medulloblastoma” with AND or OR search, considering the title and/or abstract. After, the search was carried out, the title and abstract were analyzed and those that could be included were read in full. Results: 23 articles were included. Conclusion: There is no direct relationship between the expression of the CD114 membrane receptor and mortality in patients with medulloblastoma, and additional studies should be carried out on the intracellular signaling pathways associated with this receptor and its gene, CSF3RIntrodução: Meduloblastomas são os tumores sólidos mais comuns da infância e muitos estudos buscam desenvolvimento de novos quimioterápicos com a identificação de genes cuja expressão sejam novos alvos moleculares para drogas, como receptores de membrana associados à replicação celular. Objetivo: Revisar o cohecimento existente sobre a associação da expressão de CD114 com a mortalidade no meduloblastoma. Método: Revisão narrativa colhendo informações com o material para leitura e análise selecionado a partir de pesquisa em plataformas virtuais (SciELO, Pubmed e Scopus). Inicialmente foi realizada busca por descritores relacionados ao tema, os quais foram identificados por meio do DeCS utilizando os seguintes termos: “neurocirurgia, oncologia cirúrgica, terapia de alvo molecular, meduloblastoma” ” e seus equivalentes em inglês  “neurosurgery, surgical oncology, molecular targeted therapy, medulloblastoma” com busca AND ou OR, considerando o título e/ou resumo. Feita a busca, foi realizada análise do título, resumo e lidos na íntegra aqueles que poderiam ser incluídos.  Resultados: Foram incluídos 23 artigos. Conclusão: Não há relação direta entre a expressão do receptor de membrana CD114 e a mortalidade em pacientes portadores de meduloblastoma e estudos adicionais devem ser feitos sobre as vias de sinalização intracelulares associadas a esse receptor e ao seu gene, o CSF3R.SciELO PreprintsSciELO PreprintsSciELO Preprints2023-12-15info:eu-repo/semantics/preprintinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://preprints.scielo.org/index.php/scielo/preprint/view/771710.1590/SciELOPreprints.7717porhttps://preprints.scielo.org/index.php/scielo/article/view/7717/14439Copyright (c) 2023 Jander Moreira Monteiro, Jaqueline Isadora Reis Ramos , Ian Teixeira e Sousa, Rayana Longo Bighetti-Trevisan, Jurandir Marcondes Ribas-Filho, Gustavo Rassier Isolan, Paulo Afonso Nunes Nassif , José Fernando Polanski https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMonteiro, Jander MoreiraRamos , Jaqueline Isadora ReisSousa, Ian Teixeira eBighetti-Trevisan, Rayana LongoRibas-Filho, Jurandir MarcondesIsolan, Gustavo RassierNassif , Paulo Afonso NunesPolanski , José Fernandoreponame:SciELO Preprintsinstname:Scientific Electronic Library Online (SCIELO)instacron:SCI2023-12-15T13:47:07Zoai:ops.preprints.scielo.org:preprint/7717Servidor de preprintshttps://preprints.scielo.org/index.php/scieloONGhttps://preprints.scielo.org/index.php/scielo/oaiscielo.submission@scielo.orgopendoar:2023-12-15T13:47:07SciELO Preprints - Scientific Electronic Library Online (SCIELO)false
dc.title.none.fl_str_mv CD114 MEMBRANE RECEPTORS CAN HELP IN THE ASSESSMENT OF MOLECULAR MORTALITY IN MEDULOBLASTOMAS?
RECEPTORES DE MEMBRANA CD114 PODEM AUXILIAR NA AVALIAÇÃO DA MORTALIDADE MOLECULAR EM MEDULOBLASTOMAS?
title CD114 MEMBRANE RECEPTORS CAN HELP IN THE ASSESSMENT OF MOLECULAR MORTALITY IN MEDULOBLASTOMAS?
spellingShingle CD114 MEMBRANE RECEPTORS CAN HELP IN THE ASSESSMENT OF MOLECULAR MORTALITY IN MEDULOBLASTOMAS?
Monteiro, Jander Moreira
Neurocirurgia
Oncologia cirúrgica
Terapia de alvo molecular
Meduloblastoma
Neurosurgery
Surgical oncology
Molecular targeted therapy
Medulloblastoma
title_short CD114 MEMBRANE RECEPTORS CAN HELP IN THE ASSESSMENT OF MOLECULAR MORTALITY IN MEDULOBLASTOMAS?
title_full CD114 MEMBRANE RECEPTORS CAN HELP IN THE ASSESSMENT OF MOLECULAR MORTALITY IN MEDULOBLASTOMAS?
title_fullStr CD114 MEMBRANE RECEPTORS CAN HELP IN THE ASSESSMENT OF MOLECULAR MORTALITY IN MEDULOBLASTOMAS?
title_full_unstemmed CD114 MEMBRANE RECEPTORS CAN HELP IN THE ASSESSMENT OF MOLECULAR MORTALITY IN MEDULOBLASTOMAS?
title_sort CD114 MEMBRANE RECEPTORS CAN HELP IN THE ASSESSMENT OF MOLECULAR MORTALITY IN MEDULOBLASTOMAS?
author Monteiro, Jander Moreira
author_facet Monteiro, Jander Moreira
Ramos , Jaqueline Isadora Reis
Sousa, Ian Teixeira e
Bighetti-Trevisan, Rayana Longo
Ribas-Filho, Jurandir Marcondes
Isolan, Gustavo Rassier
Nassif , Paulo Afonso Nunes
Polanski , José Fernando
author_role author
author2 Ramos , Jaqueline Isadora Reis
Sousa, Ian Teixeira e
Bighetti-Trevisan, Rayana Longo
Ribas-Filho, Jurandir Marcondes
Isolan, Gustavo Rassier
Nassif , Paulo Afonso Nunes
Polanski , José Fernando
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Monteiro, Jander Moreira
Ramos , Jaqueline Isadora Reis
Sousa, Ian Teixeira e
Bighetti-Trevisan, Rayana Longo
Ribas-Filho, Jurandir Marcondes
Isolan, Gustavo Rassier
Nassif , Paulo Afonso Nunes
Polanski , José Fernando
dc.subject.por.fl_str_mv Neurocirurgia
Oncologia cirúrgica
Terapia de alvo molecular
Meduloblastoma
Neurosurgery
Surgical oncology
Molecular targeted therapy
Medulloblastoma
topic Neurocirurgia
Oncologia cirúrgica
Terapia de alvo molecular
Meduloblastoma
Neurosurgery
Surgical oncology
Molecular targeted therapy
Medulloblastoma
description Introduction: Medulloblastomas are the most common solid tumors of childhood and many studies seek to develop new chemotherapy drugs by identifying genes whose expression is new molecular targets for drugs, such as membrane receptors associated with cell replication. Objective: To review existing knowledge about the association of CD114 expression with mortality in medulloblastoma. Method: Narrative review collecting information with material for reading and analysis selected from research on virtual platforms (SciELO, Pubmed and Scopus). Initially, a search was carried out for descriptors related to the topic, which were identified through MESH using the following terms: “neurosurgery, surgical oncology, molecular targeted therapy, medulloblastoma” with AND or OR search, considering the title and/or abstract. After, the search was carried out, the title and abstract were analyzed and those that could be included were read in full. Results: 23 articles were included. Conclusion: There is no direct relationship between the expression of the CD114 membrane receptor and mortality in patients with medulloblastoma, and additional studies should be carried out on the intracellular signaling pathways associated with this receptor and its gene, CSF3R
publishDate 2023
dc.date.none.fl_str_mv 2023-12-15
dc.type.driver.fl_str_mv info:eu-repo/semantics/preprint
info:eu-repo/semantics/publishedVersion
format preprint
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://preprints.scielo.org/index.php/scielo/preprint/view/7717
10.1590/SciELOPreprints.7717
url https://preprints.scielo.org/index.php/scielo/preprint/view/7717
identifier_str_mv 10.1590/SciELOPreprints.7717
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://preprints.scielo.org/index.php/scielo/article/view/7717/14439
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv SciELO Preprints
SciELO Preprints
SciELO Preprints
publisher.none.fl_str_mv SciELO Preprints
SciELO Preprints
SciELO Preprints
dc.source.none.fl_str_mv reponame:SciELO Preprints
instname:Scientific Electronic Library Online (SCIELO)
instacron:SCI
instname_str Scientific Electronic Library Online (SCIELO)
instacron_str SCI
institution SCI
reponame_str SciELO Preprints
collection SciELO Preprints
repository.name.fl_str_mv SciELO Preprints - Scientific Electronic Library Online (SCIELO)
repository.mail.fl_str_mv scielo.submission@scielo.org
_version_ 1797047814633553920