Perioperative analysis of patients undergoing liver transplantation at the Hospital de Clínicas da Unicamp in the context of the SARS-CoV-2 pandemic
Autor(a) principal: | |
---|---|
Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | preprint |
Idioma: | por |
Título da fonte: | SciELO Preprints |
Texto Completo: | https://preprints.scielo.org/index.php/scielo/preprint/view/7285 |
Resumo: | Introduction: SARS-CoV-2 began in 2020 and caused important changes in the number of transplants performed in hospitals and in the protocols for admitting candidates to perform the procedure. The Brazilian Association of Organ Transplantation (ABTO) recommends not performing transplants from donors with active COVID-19 infection, positive test results or with Severe Acute Respiratory Syndrome. The hepatic repercussions related to COVID-19 are presented in some reports in the medical literature. Liver changes resulting from other corona viruses such as SARS-CoV and MERS-CoV are well documented. The Hospital de Clínicas of the State University of Campinas is a tertiary center that performs solid organ transplants. Objectives: To carry out a perioperative, retrospective, descriptive analysis of liver transplants in the context of the SARS-CoV-2 pandemic carried out at the Hospital das Clínicas of the State University of Campinas from March 2020 to July 2021. Materials and Methods: Retrospective, descriptive, longitudinal cohort study based on the review of medical records of patients undergoing liver transplantation in the context of the SARS-CoV-2 pandemic from March 2020 to July 2021 at the clinical hospital of the State University of Campinas. Results: Retrospective analysis was performed on 57 patients in the period. Only 1 patient needed to be excluded because he was under 18 years old. Of the 56 patients, 52 underwent RT-PCR laboratory testing and chest tomography (CT). Of these 52 patients, only 2 tested positive, one pre-transplant (TX) and one post-operatively (post-op). Regarding chest CT scans, none of them showed typical changes for COVID pre-TX, in the post-op 4 patients presented typical chest CT scans. The average age was 55.86 years. The mortality rate was 38% and no deaths were attributed to COVID 19. The average MELD-Na scale was 20.94. Conclusion: The present study carried out at the Hospital de Clínicas da Unicamp analyzed the clinical, laboratory and radiological association to better elucidate the variables determined by COVID-19 in its diagnosis and in-hospital management. It is concluded that the SARS-CoV-2 pandemic had an impact on the routine of liver transplantation worldwide and on the service in which the study was carried out. |
id |
SCI-1_a98a6c459ecf5e86ce1fd7f6ba81a281 |
---|---|
oai_identifier_str |
oai:ops.preprints.scielo.org:preprint/7285 |
network_acronym_str |
SCI-1 |
network_name_str |
SciELO Preprints |
repository_id_str |
|
spelling |
Perioperative analysis of patients undergoing liver transplantation at the Hospital de Clínicas da Unicamp in the context of the SARS-CoV-2 pandemicAnálise perioperatória dos pacientes submetidos a transplante hepático no Hospital de Clínicas da Unicamp no contexto da pandemia de SARS-CoV-2Transplante de fígadoCOVID-19Tomografia de TóraxRT-PCRCOVID 19Chest CTliver transplantRT-PCRIntroduction: SARS-CoV-2 began in 2020 and caused important changes in the number of transplants performed in hospitals and in the protocols for admitting candidates to perform the procedure. The Brazilian Association of Organ Transplantation (ABTO) recommends not performing transplants from donors with active COVID-19 infection, positive test results or with Severe Acute Respiratory Syndrome. The hepatic repercussions related to COVID-19 are presented in some reports in the medical literature. Liver changes resulting from other corona viruses such as SARS-CoV and MERS-CoV are well documented. The Hospital de Clínicas of the State University of Campinas is a tertiary center that performs solid organ transplants. Objectives: To carry out a perioperative, retrospective, descriptive analysis of liver transplants in the context of the SARS-CoV-2 pandemic carried out at the Hospital das Clínicas of the State University of Campinas from March 2020 to July 2021. Materials and Methods: Retrospective, descriptive, longitudinal cohort study based on the review of medical records of patients undergoing liver transplantation in the context of the SARS-CoV-2 pandemic from March 2020 to July 2021 at the clinical hospital of the State University of Campinas. Results: Retrospective analysis was performed on 57 patients in the period. Only 1 patient needed to be excluded because he was under 18 years old. Of the 56 patients, 52 underwent RT-PCR laboratory testing and chest tomography (CT). Of these 52 patients, only 2 tested positive, one pre-transplant (TX) and one post-operatively (post-op). Regarding chest CT scans, none of them showed typical changes for COVID pre-TX, in the post-op 4 patients presented typical chest CT scans. The average age was 55.86 years. The mortality rate was 38% and no deaths were attributed to COVID 19. The average MELD-Na scale was 20.94. Conclusion: The present study carried out at the Hospital de Clínicas da Unicamp analyzed the clinical, laboratory and radiological association to better elucidate the variables determined by COVID-19 in its diagnosis and in-hospital management. It is concluded that the SARS-CoV-2 pandemic had an impact on the routine of liver transplantation worldwide and on the service in which the study was carried out.Introdução: A pandemia causada pelo SARS-CoV-2 teve início no ano de 2020 e ocasionou mudanças importantes no número de transplantes realizados nos hospitais e nos protocolos de admissão de candidatos para realização do procedimento. A Associação Brasileira de Transplante de Orgãos (ABTO) recomendava não realizar transplante de doadores com infecção COVID-19 ativa, teste positivo ou com Síndrome Respiratória Aguda Grave. As repercussões hepáticas relacionadas a COVID-19 são apresentadas em alguns relatos presentes na literatura médica. Estão bem documentadas as alterações hepáticas decorrentes de outros coronavírus tais como SARS-CoV e MERS-CoV. O Hospital de Clínicas da Universidade Estadual de Campinas é um centro terciário que realiza transplantes de órgãos sólidos. Objetivos: Realizar a análise retrospectiva descritiva perioperatória dos transplantes hepáticos no contexto da pandemia por SARS-CoV-2 realizados no hospital das clínicas da Universidade Estadual de Campinas no período de Março de 2020 a Julho de 2021. Materiais e Métodos: Estudo retrospectivo, descritivo de coorte longitudinal baseado na revisão dos prontuários dos pacientes submetidos ao transplante hepático no contexto da pandemia por SARS-CoV-2 no período de Março de 2020 a Julho de 2021 no hospital de clínicas da Universidade Estadual de Campinas. Resultados: A análise retrospectiva foi realizada em 57 pacientes no período. Apenas 1 paciente precisou ser excluído por ter menos de 18 anos. Dos 56 pacientes, 52 realizaram coleta do exame laboratorial RT-PCR e tomografia (TC) de tórax. Desses 52 pacientes apenas 2 positivaram o exame, um pré transplante (TX) e um no pós-operatório (pós-op). Em relação às TC de tórax nenhuma apresentava alterações típicas para COVID pré TX, no pós-op 4 pacientes apresentaram TC típicas. A média de idade foi de 55,86 anos. A taxa de mortalidade foi de 38% e nenhum óbito foi atribuído ao COVID 19. A escala de MELDNa média foi de 20,94. Conclusão: O presente estudo realizado no Hospital de Clínicas da Unicamp analisou a associação clínica, laboratorial e radiológica para melhor elucidar as variáveis determinadas pela COVID-19 no seu diagnóstico e manejo intra-hospitalar. Conclui-se que a pandemia por SARS-CoV-2 teve impacto na rotina de realização do transplante hepático mundialmente e no serviço no qual o estudo foi realizado.SciELO PreprintsSciELO PreprintsSciELO Preprints2023-11-27info:eu-repo/semantics/preprintinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://preprints.scielo.org/index.php/scielo/preprint/view/728510.1590/SciELOPreprints.7285porhttps://preprints.scielo.org/index.php/scielo/article/view/7285/13930Copyright (c) 2023 Marcos De Simone Melo, Adilson Roberto Cardoso, Cristina Aparecida Arrivabene Caruy, Derli Conceição Munhoz, Sérgio San Juan Dertkigil, André Henrique Miyoshi, Thierry Lodomez Mecchi, Isabeli Camila Miyoshi, Simone Reges Perales, Elaine Cristina de Ataíde, Ilka Fatima Santana Ferreira Boinhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMelo, Marcos De SimoneCardoso, Adilson RobertoCaruy, Cristina Aparecida ArrivabeneMunhoz, Derli ConceiçãoDertkigil, Sérgio San JuanMiyoshi, André HenriqueMecchi, Thierry LodomezMiyoshi, Isabeli CamilaPerales, Simone RegesAtaíde, Elaine Cristina deBoin, Ilka Fatima Santana Ferreirareponame:SciELO Preprintsinstname:Scientific Electronic Library Online (SCIELO)instacron:SCI2023-11-24T13:37:16Zoai:ops.preprints.scielo.org:preprint/7285Servidor de preprintshttps://preprints.scielo.org/index.php/scieloONGhttps://preprints.scielo.org/index.php/scielo/oaiscielo.submission@scielo.orgopendoar:2023-11-24T13:37:16SciELO Preprints - Scientific Electronic Library Online (SCIELO)false |
dc.title.none.fl_str_mv |
Perioperative analysis of patients undergoing liver transplantation at the Hospital de Clínicas da Unicamp in the context of the SARS-CoV-2 pandemic Análise perioperatória dos pacientes submetidos a transplante hepático no Hospital de Clínicas da Unicamp no contexto da pandemia de SARS-CoV-2 |
title |
Perioperative analysis of patients undergoing liver transplantation at the Hospital de Clínicas da Unicamp in the context of the SARS-CoV-2 pandemic |
spellingShingle |
Perioperative analysis of patients undergoing liver transplantation at the Hospital de Clínicas da Unicamp in the context of the SARS-CoV-2 pandemic Melo, Marcos De Simone Transplante de fígado COVID-19 Tomografia de Tórax RT-PCR COVID 19 Chest CT liver transplant RT-PCR |
title_short |
Perioperative analysis of patients undergoing liver transplantation at the Hospital de Clínicas da Unicamp in the context of the SARS-CoV-2 pandemic |
title_full |
Perioperative analysis of patients undergoing liver transplantation at the Hospital de Clínicas da Unicamp in the context of the SARS-CoV-2 pandemic |
title_fullStr |
Perioperative analysis of patients undergoing liver transplantation at the Hospital de Clínicas da Unicamp in the context of the SARS-CoV-2 pandemic |
title_full_unstemmed |
Perioperative analysis of patients undergoing liver transplantation at the Hospital de Clínicas da Unicamp in the context of the SARS-CoV-2 pandemic |
title_sort |
Perioperative analysis of patients undergoing liver transplantation at the Hospital de Clínicas da Unicamp in the context of the SARS-CoV-2 pandemic |
author |
Melo, Marcos De Simone |
author_facet |
Melo, Marcos De Simone Cardoso, Adilson Roberto Caruy, Cristina Aparecida Arrivabene Munhoz, Derli Conceição Dertkigil, Sérgio San Juan Miyoshi, André Henrique Mecchi, Thierry Lodomez Miyoshi, Isabeli Camila Perales, Simone Reges Ataíde, Elaine Cristina de Boin, Ilka Fatima Santana Ferreira |
author_role |
author |
author2 |
Cardoso, Adilson Roberto Caruy, Cristina Aparecida Arrivabene Munhoz, Derli Conceição Dertkigil, Sérgio San Juan Miyoshi, André Henrique Mecchi, Thierry Lodomez Miyoshi, Isabeli Camila Perales, Simone Reges Ataíde, Elaine Cristina de Boin, Ilka Fatima Santana Ferreira |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Melo, Marcos De Simone Cardoso, Adilson Roberto Caruy, Cristina Aparecida Arrivabene Munhoz, Derli Conceição Dertkigil, Sérgio San Juan Miyoshi, André Henrique Mecchi, Thierry Lodomez Miyoshi, Isabeli Camila Perales, Simone Reges Ataíde, Elaine Cristina de Boin, Ilka Fatima Santana Ferreira |
dc.subject.por.fl_str_mv |
Transplante de fígado COVID-19 Tomografia de Tórax RT-PCR COVID 19 Chest CT liver transplant RT-PCR |
topic |
Transplante de fígado COVID-19 Tomografia de Tórax RT-PCR COVID 19 Chest CT liver transplant RT-PCR |
description |
Introduction: SARS-CoV-2 began in 2020 and caused important changes in the number of transplants performed in hospitals and in the protocols for admitting candidates to perform the procedure. The Brazilian Association of Organ Transplantation (ABTO) recommends not performing transplants from donors with active COVID-19 infection, positive test results or with Severe Acute Respiratory Syndrome. The hepatic repercussions related to COVID-19 are presented in some reports in the medical literature. Liver changes resulting from other corona viruses such as SARS-CoV and MERS-CoV are well documented. The Hospital de Clínicas of the State University of Campinas is a tertiary center that performs solid organ transplants. Objectives: To carry out a perioperative, retrospective, descriptive analysis of liver transplants in the context of the SARS-CoV-2 pandemic carried out at the Hospital das Clínicas of the State University of Campinas from March 2020 to July 2021. Materials and Methods: Retrospective, descriptive, longitudinal cohort study based on the review of medical records of patients undergoing liver transplantation in the context of the SARS-CoV-2 pandemic from March 2020 to July 2021 at the clinical hospital of the State University of Campinas. Results: Retrospective analysis was performed on 57 patients in the period. Only 1 patient needed to be excluded because he was under 18 years old. Of the 56 patients, 52 underwent RT-PCR laboratory testing and chest tomography (CT). Of these 52 patients, only 2 tested positive, one pre-transplant (TX) and one post-operatively (post-op). Regarding chest CT scans, none of them showed typical changes for COVID pre-TX, in the post-op 4 patients presented typical chest CT scans. The average age was 55.86 years. The mortality rate was 38% and no deaths were attributed to COVID 19. The average MELD-Na scale was 20.94. Conclusion: The present study carried out at the Hospital de Clínicas da Unicamp analyzed the clinical, laboratory and radiological association to better elucidate the variables determined by COVID-19 in its diagnosis and in-hospital management. It is concluded that the SARS-CoV-2 pandemic had an impact on the routine of liver transplantation worldwide and on the service in which the study was carried out. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-11-27 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/preprint info:eu-repo/semantics/publishedVersion |
format |
preprint |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://preprints.scielo.org/index.php/scielo/preprint/view/7285 10.1590/SciELOPreprints.7285 |
url |
https://preprints.scielo.org/index.php/scielo/preprint/view/7285 |
identifier_str_mv |
10.1590/SciELOPreprints.7285 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://preprints.scielo.org/index.php/scielo/article/view/7285/13930 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
SciELO Preprints SciELO Preprints SciELO Preprints |
publisher.none.fl_str_mv |
SciELO Preprints SciELO Preprints SciELO Preprints |
dc.source.none.fl_str_mv |
reponame:SciELO Preprints instname:Scientific Electronic Library Online (SCIELO) instacron:SCI |
instname_str |
Scientific Electronic Library Online (SCIELO) |
instacron_str |
SCI |
institution |
SCI |
reponame_str |
SciELO Preprints |
collection |
SciELO Preprints |
repository.name.fl_str_mv |
SciELO Preprints - Scientific Electronic Library Online (SCIELO) |
repository.mail.fl_str_mv |
scielo.submission@scielo.org |
_version_ |
1797047814096683008 |