Chemical prospecting and antioxidant, anticholinesterase and antifungal activity of ethanol extracts from Senna Mill. species. (Fabaceae)

Detalhes bibliográficos
Autor(a) principal: Neves, Andréa Maria
Data de Publicação: 2022
Outros Autores: Morais, Selene Maia de, Santos, Hélcio Silva dos, Ferreira, Marcílio Matos, Cruz, Ricardo Carneiro Vera, Souza, Elnatan Bezerra de, Andrade, Lúcia Betânia da Silva, Fontenelle, Raquel Oliveira dos Santos
Tipo de documento: preprint
Idioma: por
Título da fonte: SciELO Preprints
Texto Completo: https://preprints.scielo.org/index.php/scielo/preprint/view/3468
Resumo: The objective of this work was to evaluate the chemical profile, total phenol content and the antioxidant, antiacetylcholinesterase and antifungal activities of ethanol extracts from leaves (EEF) and stem (EEC) of five species of Senna, as well as to evaluate the correlation between the content of total phenols with the DPPH free radical scavenging activity and with the inhibition of the acetylcholinesterase AChEI enzyme. The phytochemical test showed the presence of secondary metabolites in all extracts. The EEF and EEC of Senna trachypus, stood out for presenting the highest values of total phenols. S. trachypus EEF and EEC showed the best action on the acetylcholinesterase enzyme. All species showed antioxidant activity, especially the EEF from S. trachypus. A strong correlation was observed for the variables total phenols and antioxidant activity (r = -0.71), very strong for total phenols and anti-acetylcholinesterase (r = -0.84) and moderate activity for antioxidant and anti-acetylcholinesterase activity (r = 0.43). Only S. trachypus extracts showed activity against all dermatophytes, when compared to the other species. The species S. trachypus was considered the most promising plant for further studies, in order to find compounds with pharmacological actions.
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spelling Chemical prospecting and antioxidant, anticholinesterase and antifungal activity of ethanol extracts from Senna Mill. species. (Fabaceae)Prospecção química, atividade antioxidante, anticolinesterásica e antifúngica de extratos etanólicos de espécies de Senna Mill. (Fabaceae)acetilcolinesterasedermatófitosfitoquímicaprodutos naturaisradicais livresacetylcholinesterasedermatophytesphytochemistrynatural productsfree radicalsThe objective of this work was to evaluate the chemical profile, total phenol content and the antioxidant, antiacetylcholinesterase and antifungal activities of ethanol extracts from leaves (EEF) and stem (EEC) of five species of Senna, as well as to evaluate the correlation between the content of total phenols with the DPPH free radical scavenging activity and with the inhibition of the acetylcholinesterase AChEI enzyme. The phytochemical test showed the presence of secondary metabolites in all extracts. The EEF and EEC of Senna trachypus, stood out for presenting the highest values of total phenols. S. trachypus EEF and EEC showed the best action on the acetylcholinesterase enzyme. All species showed antioxidant activity, especially the EEF from S. trachypus. A strong correlation was observed for the variables total phenols and antioxidant activity (r = -0.71), very strong for total phenols and anti-acetylcholinesterase (r = -0.84) and moderate activity for antioxidant and anti-acetylcholinesterase activity (r = 0.43). Only S. trachypus extracts showed activity against all dermatophytes, when compared to the other species. The species S. trachypus was considered the most promising plant for further studies, in order to find compounds with pharmacological actions.O objetivo deste trabalho foi avaliar o perfil químico, teor de fenóis totais e as atividades antioxidante, antiacetilcolinesterásica e antifúngica dos extratos etanólicos das folhas (EEF) e do caule (EEC) de cinco espécies de Senna, bem como avaliar a correlação entre o conteúdo de fenóis totais com a atividade sequestradora do radical livre DPPH e com a inibição da enzima acetilcolinesterase AChEI. No teste fitoquímico, evidenciou-se a presença de metabólitos secundários em todos os extratos. Os EEF e EEC de Senna trachypus, destacaram-se por apresentar os maiores valores de fenóis totais. Os EEF e EEC de S. trachypus mostraram a melhor ação sobre a enzima acetilcolinesterase. Todas as espécies apresentaram atividade antioxidante, em especial o EEF de S. trachypus. Foi observado correlação forte para as variáveis fenóis totais e atividade antioxidante (r = -0,71), muito forte para fenóis totais e antiacetilcolinesterase (r = -0,84) e atividade moderada para atividade antioxidante e antiacetilcolinesterase (0,43). Apenas os extratos de S. trachypus apresentaram atividade contra todos os dermatófitos, quando comparado às demais espécies. A espécie S. trachypus foi considerada a planta mais promissora para estudos subsequentes, a fim de encontrar compostos com ações farmacológicas.SciELO PreprintsSciELO PreprintsSciELO Preprints2022-01-10info:eu-repo/semantics/preprintinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://preprints.scielo.org/index.php/scielo/preprint/view/346810.1590/2236-8906-111/2020porhttps://preprints.scielo.org/index.php/scielo/article/view/3468/6336Copyright (c) 2022 Andréa Maria Neves, Selene Maia de Morais, Hélcio Silva dos Santos, Marcílio Matos Ferreira, Ricardo Carneiro Vera Cruz, Elnatan Bezerra de Souza, Lúcia Betânia da Silva Andrade, Raquel Oliveira dos Santos Fontenellehttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessNeves, Andréa MariaMorais, Selene Maia deSantos, Hélcio Silva dosFerreira, Marcílio MatosCruz, Ricardo Carneiro VeraSouza, Elnatan Bezerra deAndrade, Lúcia Betânia da SilvaFontenelle, Raquel Oliveira dos Santosreponame:SciELO Preprintsinstname:SciELOinstacron:SCI2022-01-10T14:58:05Zoai:ops.preprints.scielo.org:preprint/3468Servidor de preprintshttps://preprints.scielo.org/index.php/scieloONGhttps://preprints.scielo.org/index.php/scielo/oaiscielo.submission@scielo.orgopendoar:2022-01-10T14:58:05SciELO Preprints - SciELOfalse
dc.title.none.fl_str_mv Chemical prospecting and antioxidant, anticholinesterase and antifungal activity of ethanol extracts from Senna Mill. species. (Fabaceae)
Prospecção química, atividade antioxidante, anticolinesterásica e antifúngica de extratos etanólicos de espécies de Senna Mill. (Fabaceae)
title Chemical prospecting and antioxidant, anticholinesterase and antifungal activity of ethanol extracts from Senna Mill. species. (Fabaceae)
spellingShingle Chemical prospecting and antioxidant, anticholinesterase and antifungal activity of ethanol extracts from Senna Mill. species. (Fabaceae)
Neves, Andréa Maria
acetilcolinesterase
dermatófitos
fitoquímica
produtos naturais
radicais livres
acetylcholinesterase
dermatophytes
phytochemistry
natural products
free radicals
title_short Chemical prospecting and antioxidant, anticholinesterase and antifungal activity of ethanol extracts from Senna Mill. species. (Fabaceae)
title_full Chemical prospecting and antioxidant, anticholinesterase and antifungal activity of ethanol extracts from Senna Mill. species. (Fabaceae)
title_fullStr Chemical prospecting and antioxidant, anticholinesterase and antifungal activity of ethanol extracts from Senna Mill. species. (Fabaceae)
title_full_unstemmed Chemical prospecting and antioxidant, anticholinesterase and antifungal activity of ethanol extracts from Senna Mill. species. (Fabaceae)
title_sort Chemical prospecting and antioxidant, anticholinesterase and antifungal activity of ethanol extracts from Senna Mill. species. (Fabaceae)
author Neves, Andréa Maria
author_facet Neves, Andréa Maria
Morais, Selene Maia de
Santos, Hélcio Silva dos
Ferreira, Marcílio Matos
Cruz, Ricardo Carneiro Vera
Souza, Elnatan Bezerra de
Andrade, Lúcia Betânia da Silva
Fontenelle, Raquel Oliveira dos Santos
author_role author
author2 Morais, Selene Maia de
Santos, Hélcio Silva dos
Ferreira, Marcílio Matos
Cruz, Ricardo Carneiro Vera
Souza, Elnatan Bezerra de
Andrade, Lúcia Betânia da Silva
Fontenelle, Raquel Oliveira dos Santos
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Neves, Andréa Maria
Morais, Selene Maia de
Santos, Hélcio Silva dos
Ferreira, Marcílio Matos
Cruz, Ricardo Carneiro Vera
Souza, Elnatan Bezerra de
Andrade, Lúcia Betânia da Silva
Fontenelle, Raquel Oliveira dos Santos
dc.subject.por.fl_str_mv acetilcolinesterase
dermatófitos
fitoquímica
produtos naturais
radicais livres
acetylcholinesterase
dermatophytes
phytochemistry
natural products
free radicals
topic acetilcolinesterase
dermatófitos
fitoquímica
produtos naturais
radicais livres
acetylcholinesterase
dermatophytes
phytochemistry
natural products
free radicals
description The objective of this work was to evaluate the chemical profile, total phenol content and the antioxidant, antiacetylcholinesterase and antifungal activities of ethanol extracts from leaves (EEF) and stem (EEC) of five species of Senna, as well as to evaluate the correlation between the content of total phenols with the DPPH free radical scavenging activity and with the inhibition of the acetylcholinesterase AChEI enzyme. The phytochemical test showed the presence of secondary metabolites in all extracts. The EEF and EEC of Senna trachypus, stood out for presenting the highest values of total phenols. S. trachypus EEF and EEC showed the best action on the acetylcholinesterase enzyme. All species showed antioxidant activity, especially the EEF from S. trachypus. A strong correlation was observed for the variables total phenols and antioxidant activity (r = -0.71), very strong for total phenols and anti-acetylcholinesterase (r = -0.84) and moderate activity for antioxidant and anti-acetylcholinesterase activity (r = 0.43). Only S. trachypus extracts showed activity against all dermatophytes, when compared to the other species. The species S. trachypus was considered the most promising plant for further studies, in order to find compounds with pharmacological actions.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-10
dc.type.driver.fl_str_mv info:eu-repo/semantics/preprint
info:eu-repo/semantics/publishedVersion
format preprint
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://preprints.scielo.org/index.php/scielo/preprint/view/3468
10.1590/2236-8906-111/2020
url https://preprints.scielo.org/index.php/scielo/preprint/view/3468
identifier_str_mv 10.1590/2236-8906-111/2020
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://preprints.scielo.org/index.php/scielo/article/view/3468/6336
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv SciELO Preprints
SciELO Preprints
SciELO Preprints
publisher.none.fl_str_mv SciELO Preprints
SciELO Preprints
SciELO Preprints
dc.source.none.fl_str_mv reponame:SciELO Preprints
instname:SciELO
instacron:SCI
instname_str SciELO
instacron_str SCI
institution SCI
reponame_str SciELO Preprints
collection SciELO Preprints
repository.name.fl_str_mv SciELO Preprints - SciELO
repository.mail.fl_str_mv scielo.submission@scielo.org
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