Transgenic mosquitoes for malaria control: progresses and challenges
Main Author: | |
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Publication Date: | 2003 |
Other Authors: | |
Format: | Article |
Language: | eng |
Source: | Neotropical entomology (Online) |
Download full: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-566X2003000400001 |
Summary: | Malaria kills millions of people every year and the current strategies to control the disease, such as insecticides and drugs have not been completely efficient. Because of that, novel means to fight against malaria are of utmost importance. Advances in the study of the mosquito vector and its interactions with the malaria parasite made scientists think that it is possible to genetically manipulate the mosquitoes to make them inefficient vectors. Here we review the advances on the introduction of foreign genes into the mosquito germ line, the characterization of tissue-specific promoters, the identification of gene products that block development of the parasite in the mosquito, and we discuss the recent generation of transgenic mosquitoes impaired for malaria transmission. While much progress has been made, many years of research are still needed before transgenic mosquitoes can be used in the field. |
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Transgenic mosquitoes for malaria control: progresses and challengesMalariatransgenesistransmission blockingPlasmodiumMalaria kills millions of people every year and the current strategies to control the disease, such as insecticides and drugs have not been completely efficient. Because of that, novel means to fight against malaria are of utmost importance. Advances in the study of the mosquito vector and its interactions with the malaria parasite made scientists think that it is possible to genetically manipulate the mosquitoes to make them inefficient vectors. Here we review the advances on the introduction of foreign genes into the mosquito germ line, the characterization of tissue-specific promoters, the identification of gene products that block development of the parasite in the mosquito, and we discuss the recent generation of transgenic mosquitoes impaired for malaria transmission. While much progress has been made, many years of research are still needed before transgenic mosquitoes can be used in the field.Sociedade Entomológica do Brasil2003-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-566X2003000400001Neotropical Entomology v.32 n.4 2003reponame:Neotropical entomology (Online)instname:Sociedade Entomológica do Brasil (SEB)instacron:SEB10.1590/S1519-566X2003000400001info:eu-repo/semantics/openAccessMoreira,Luciano A.Jacobs-Lorena,Marceloeng2004-03-09T00:00:00Zoai:scielo:S1519-566X2003000400001Revistahttp://www.scielo.br/neONGhttps://old.scielo.br/oai/scielo-oai.php||editor@seb.org.br1678-80521519-566Xopendoar:2004-03-09T00:00Neotropical entomology (Online) - Sociedade Entomológica do Brasil (SEB)false |
dc.title.none.fl_str_mv |
Transgenic mosquitoes for malaria control: progresses and challenges |
title |
Transgenic mosquitoes for malaria control: progresses and challenges |
spellingShingle |
Transgenic mosquitoes for malaria control: progresses and challenges Moreira,Luciano A. Malaria transgenesis transmission blocking Plasmodium |
title_short |
Transgenic mosquitoes for malaria control: progresses and challenges |
title_full |
Transgenic mosquitoes for malaria control: progresses and challenges |
title_fullStr |
Transgenic mosquitoes for malaria control: progresses and challenges |
title_full_unstemmed |
Transgenic mosquitoes for malaria control: progresses and challenges |
title_sort |
Transgenic mosquitoes for malaria control: progresses and challenges |
author |
Moreira,Luciano A. |
author_facet |
Moreira,Luciano A. Jacobs-Lorena,Marcelo |
author_role |
author |
author2 |
Jacobs-Lorena,Marcelo |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Moreira,Luciano A. Jacobs-Lorena,Marcelo |
dc.subject.por.fl_str_mv |
Malaria transgenesis transmission blocking Plasmodium |
topic |
Malaria transgenesis transmission blocking Plasmodium |
description |
Malaria kills millions of people every year and the current strategies to control the disease, such as insecticides and drugs have not been completely efficient. Because of that, novel means to fight against malaria are of utmost importance. Advances in the study of the mosquito vector and its interactions with the malaria parasite made scientists think that it is possible to genetically manipulate the mosquitoes to make them inefficient vectors. Here we review the advances on the introduction of foreign genes into the mosquito germ line, the characterization of tissue-specific promoters, the identification of gene products that block development of the parasite in the mosquito, and we discuss the recent generation of transgenic mosquitoes impaired for malaria transmission. While much progress has been made, many years of research are still needed before transgenic mosquitoes can be used in the field. |
publishDate |
2003 |
dc.date.none.fl_str_mv |
2003-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-566X2003000400001 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-566X2003000400001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1519-566X2003000400001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Entomológica do Brasil |
publisher.none.fl_str_mv |
Sociedade Entomológica do Brasil |
dc.source.none.fl_str_mv |
Neotropical Entomology v.32 n.4 2003 reponame:Neotropical entomology (Online) instname:Sociedade Entomológica do Brasil (SEB) instacron:SEB |
instname_str |
Sociedade Entomológica do Brasil (SEB) |
instacron_str |
SEB |
institution |
SEB |
reponame_str |
Neotropical entomology (Online) |
collection |
Neotropical entomology (Online) |
repository.name.fl_str_mv |
Neotropical entomology (Online) - Sociedade Entomológica do Brasil (SEB) |
repository.mail.fl_str_mv |
||editor@seb.org.br |
_version_ |
1754820844313378816 |