Lithium and methylphenidate: opposite effects on perirenal brown fat

Detalhes bibliográficos
Autor(a) principal: Oliveira,José Menna
Data de Publicação: 2010
Outros Autores: Crema,Leonardo Machado, Diehl,Luísa Amália, Pettenuzzo,Letícia Ferreira, Bertinette,Liane Tavares, Dalmaz,Carla, Rocha,Elizabete Rocha da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista de Psiquiatria do Rio Grande do Sul
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-81082010000200002
Resumo: OBJECTIVE: To evaluate the effects of the administration of lithium to adult rats on brown (perirenal) and white (inguinal) adipose tissues and to assess whether methylphenidate modulates lithium effects. METHODS: Twenty-five adult male Wistar rats were fed with either regular or lithium-containing chow for 30 days. Between days 15 to 30 of treatment, animals received daily intraperitoneal administrations of either methylphenidate or saline. RESULTS: Lithium significantly reduced perirenal fat, and this effect was minimized by the administration of methylphenidate. There were no significant differences between the groups in terms of the effects of lithium on inguinal fat. CONCLUSION: Our findings suggest that different effects on white and brown tissue distribution may be involved in lithium-induced weight gain.
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spelling Lithium and methylphenidate: opposite effects on perirenal brown fatLithiummethylphenidateweight gainobesityOBJECTIVE: To evaluate the effects of the administration of lithium to adult rats on brown (perirenal) and white (inguinal) adipose tissues and to assess whether methylphenidate modulates lithium effects. METHODS: Twenty-five adult male Wistar rats were fed with either regular or lithium-containing chow for 30 days. Between days 15 to 30 of treatment, animals received daily intraperitoneal administrations of either methylphenidate or saline. RESULTS: Lithium significantly reduced perirenal fat, and this effect was minimized by the administration of methylphenidate. There were no significant differences between the groups in terms of the effects of lithium on inguinal fat. CONCLUSION: Our findings suggest that different effects on white and brown tissue distribution may be involved in lithium-induced weight gain.Sociedade de Psiquiatria do Rio Grande do Sul2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-81082010000200002Revista de Psiquiatria do Rio Grande do Sul v.32 n.2 2010reponame:Revista de Psiquiatria do Rio Grande do Sulinstname:Sociedade de Psiquiatria do Rio Grande do Sul (SPRGS)instacron:SPRGS10.1590/S0101-81082010000200002info:eu-repo/semantics/openAccessOliveira,José MennaCrema,Leonardo MachadoDiehl,Luísa AmáliaPettenuzzo,Letícia FerreiraBertinette,Liane TavaresDalmaz,CarlaRocha,Elizabete Rocha daeng2010-08-26T00:00:00Zoai:scielo:S0101-81082010000200002Revistahttp://www.scielo.br/rprssONGhttps://old.scielo.br/oai/scielo-oai.php||revista@aprs.org.br0101-81080101-8108opendoar:2010-08-26T00:00Revista de Psiquiatria do Rio Grande do Sul - Sociedade de Psiquiatria do Rio Grande do Sul (SPRGS)false
dc.title.none.fl_str_mv Lithium and methylphenidate: opposite effects on perirenal brown fat
title Lithium and methylphenidate: opposite effects on perirenal brown fat
spellingShingle Lithium and methylphenidate: opposite effects on perirenal brown fat
Oliveira,José Menna
Lithium
methylphenidate
weight gain
obesity
title_short Lithium and methylphenidate: opposite effects on perirenal brown fat
title_full Lithium and methylphenidate: opposite effects on perirenal brown fat
title_fullStr Lithium and methylphenidate: opposite effects on perirenal brown fat
title_full_unstemmed Lithium and methylphenidate: opposite effects on perirenal brown fat
title_sort Lithium and methylphenidate: opposite effects on perirenal brown fat
author Oliveira,José Menna
author_facet Oliveira,José Menna
Crema,Leonardo Machado
Diehl,Luísa Amália
Pettenuzzo,Letícia Ferreira
Bertinette,Liane Tavares
Dalmaz,Carla
Rocha,Elizabete Rocha da
author_role author
author2 Crema,Leonardo Machado
Diehl,Luísa Amália
Pettenuzzo,Letícia Ferreira
Bertinette,Liane Tavares
Dalmaz,Carla
Rocha,Elizabete Rocha da
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira,José Menna
Crema,Leonardo Machado
Diehl,Luísa Amália
Pettenuzzo,Letícia Ferreira
Bertinette,Liane Tavares
Dalmaz,Carla
Rocha,Elizabete Rocha da
dc.subject.por.fl_str_mv Lithium
methylphenidate
weight gain
obesity
topic Lithium
methylphenidate
weight gain
obesity
description OBJECTIVE: To evaluate the effects of the administration of lithium to adult rats on brown (perirenal) and white (inguinal) adipose tissues and to assess whether methylphenidate modulates lithium effects. METHODS: Twenty-five adult male Wistar rats were fed with either regular or lithium-containing chow for 30 days. Between days 15 to 30 of treatment, animals received daily intraperitoneal administrations of either methylphenidate or saline. RESULTS: Lithium significantly reduced perirenal fat, and this effect was minimized by the administration of methylphenidate. There were no significant differences between the groups in terms of the effects of lithium on inguinal fat. CONCLUSION: Our findings suggest that different effects on white and brown tissue distribution may be involved in lithium-induced weight gain.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-81082010000200002
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0101-81082010000200002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade de Psiquiatria do Rio Grande do Sul
publisher.none.fl_str_mv Sociedade de Psiquiatria do Rio Grande do Sul
dc.source.none.fl_str_mv Revista de Psiquiatria do Rio Grande do Sul v.32 n.2 2010
reponame:Revista de Psiquiatria do Rio Grande do Sul
instname:Sociedade de Psiquiatria do Rio Grande do Sul (SPRGS)
instacron:SPRGS
instname_str Sociedade de Psiquiatria do Rio Grande do Sul (SPRGS)
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institution SPRGS
reponame_str Revista de Psiquiatria do Rio Grande do Sul
collection Revista de Psiquiatria do Rio Grande do Sul
repository.name.fl_str_mv Revista de Psiquiatria do Rio Grande do Sul - Sociedade de Psiquiatria do Rio Grande do Sul (SPRGS)
repository.mail.fl_str_mv ||revista@aprs.org.br
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