Association of sleep disorders with heart rate variability in children and adolescents with cystic fibrosis
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Paulista de Pediatria (Ed. Português. Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822022000100411 |
Resumo: | ABSTRACT Objective: To assess the association of sleep disorders with the findings of heart rate variability (HRV) in children and adolescents with cystic fibrosis (CF). Methods: Cross-sectional study including children and adolescents aged six to 18 years with a clinical diagnosis of CF. Sociodemographic and clinical data were collected. Sleep disorders were evaluated using baseline nocturnal polysomnography. The autonomic nervous system (ANS) was evaluated through resting HRV. Results: A total of 30 individuals (11.2 years) with a mean forced expiratory volume in the first second (FEV1) of 62.7% were included. The respiratory disturbance index presented a median of 2.6 and obstructive sleep apnea syndrome (OSAS) was identified in 30%. In the HRV analysis, a mean standard deviation of all inter-beat (RR) intervals (SDNN) of 60.8±45.9ms was found. There was a significant correlation between the HRV low-frequency/high-frequency (LF/HF) global modulation index and the minimum SpO2 during sleep in patients with FEV1<60% (r=0.71; p=0.02). The prevalence of sleep disorders and HRV abnormalities was higher in individuals with lesser pulmonary function (FEV1<60%). Conclusions: The results indicate a weak correlation of sleep disorders (minimum SpO2) with HRV parameters (LH/HF) in children and adolescents with CF. When pulmonary function was reduced, a stronger correlation was found, highlighting the influence of disease severity. A high prevalence of ANS disorders, nocturnal hypoxemia, and presence of OSAS was also found. |
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Association of sleep disorders with heart rate variability in children and adolescents with cystic fibrosisCystic fibrosisSleep disordersHeart rate variabilityHypoxemiaPediatricsABSTRACT Objective: To assess the association of sleep disorders with the findings of heart rate variability (HRV) in children and adolescents with cystic fibrosis (CF). Methods: Cross-sectional study including children and adolescents aged six to 18 years with a clinical diagnosis of CF. Sociodemographic and clinical data were collected. Sleep disorders were evaluated using baseline nocturnal polysomnography. The autonomic nervous system (ANS) was evaluated through resting HRV. Results: A total of 30 individuals (11.2 years) with a mean forced expiratory volume in the first second (FEV1) of 62.7% were included. The respiratory disturbance index presented a median of 2.6 and obstructive sleep apnea syndrome (OSAS) was identified in 30%. In the HRV analysis, a mean standard deviation of all inter-beat (RR) intervals (SDNN) of 60.8±45.9ms was found. There was a significant correlation between the HRV low-frequency/high-frequency (LF/HF) global modulation index and the minimum SpO2 during sleep in patients with FEV1<60% (r=0.71; p=0.02). The prevalence of sleep disorders and HRV abnormalities was higher in individuals with lesser pulmonary function (FEV1<60%). Conclusions: The results indicate a weak correlation of sleep disorders (minimum SpO2) with HRV parameters (LH/HF) in children and adolescents with CF. When pulmonary function was reduced, a stronger correlation was found, highlighting the influence of disease severity. A high prevalence of ANS disorders, nocturnal hypoxemia, and presence of OSAS was also found.Sociedade de Pediatria de São Paulo2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822022000100411Revista Paulista de Pediatria v.40 2022reponame:Revista Paulista de Pediatria (Ed. Português. Online)instname:Sociedade de Pediatria de São Paulo (SPSP)instacron:SPSP10.1590/1984-0462/2022/40/2020295info:eu-repo/semantics/openAccessLugao,Rodrigo dos SantosBarbosa,Roberta Ribeiro BatistaCoelho,Pitiguara de FreitasLiberato,Fernanda Mayrink GonçalvesVidal,Pâmela ReisCarvalho,Roberta Barcellos Couto Olimpio deMelotti,Roberta de Cássia Nunes CruzDonadio,Márcio Vinícius Fagundeseng2021-08-27T00:00:00Zoai:scielo:S0103-05822022000100411Revistahttps://www.rpped.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.phppediatria@spsp.org.br||rpp@spsp.org.br1984-04620103-0582opendoar:2021-08-27T00:00Revista Paulista de Pediatria (Ed. Português. Online) - Sociedade de Pediatria de São Paulo (SPSP)false |
dc.title.none.fl_str_mv |
Association of sleep disorders with heart rate variability in children and adolescents with cystic fibrosis |
title |
Association of sleep disorders with heart rate variability in children and adolescents with cystic fibrosis |
spellingShingle |
Association of sleep disorders with heart rate variability in children and adolescents with cystic fibrosis Lugao,Rodrigo dos Santos Cystic fibrosis Sleep disorders Heart rate variability Hypoxemia Pediatrics |
title_short |
Association of sleep disorders with heart rate variability in children and adolescents with cystic fibrosis |
title_full |
Association of sleep disorders with heart rate variability in children and adolescents with cystic fibrosis |
title_fullStr |
Association of sleep disorders with heart rate variability in children and adolescents with cystic fibrosis |
title_full_unstemmed |
Association of sleep disorders with heart rate variability in children and adolescents with cystic fibrosis |
title_sort |
Association of sleep disorders with heart rate variability in children and adolescents with cystic fibrosis |
author |
Lugao,Rodrigo dos Santos |
author_facet |
Lugao,Rodrigo dos Santos Barbosa,Roberta Ribeiro Batista Coelho,Pitiguara de Freitas Liberato,Fernanda Mayrink Gonçalves Vidal,Pâmela Reis Carvalho,Roberta Barcellos Couto Olimpio de Melotti,Roberta de Cássia Nunes Cruz Donadio,Márcio Vinícius Fagundes |
author_role |
author |
author2 |
Barbosa,Roberta Ribeiro Batista Coelho,Pitiguara de Freitas Liberato,Fernanda Mayrink Gonçalves Vidal,Pâmela Reis Carvalho,Roberta Barcellos Couto Olimpio de Melotti,Roberta de Cássia Nunes Cruz Donadio,Márcio Vinícius Fagundes |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Lugao,Rodrigo dos Santos Barbosa,Roberta Ribeiro Batista Coelho,Pitiguara de Freitas Liberato,Fernanda Mayrink Gonçalves Vidal,Pâmela Reis Carvalho,Roberta Barcellos Couto Olimpio de Melotti,Roberta de Cássia Nunes Cruz Donadio,Márcio Vinícius Fagundes |
dc.subject.por.fl_str_mv |
Cystic fibrosis Sleep disorders Heart rate variability Hypoxemia Pediatrics |
topic |
Cystic fibrosis Sleep disorders Heart rate variability Hypoxemia Pediatrics |
description |
ABSTRACT Objective: To assess the association of sleep disorders with the findings of heart rate variability (HRV) in children and adolescents with cystic fibrosis (CF). Methods: Cross-sectional study including children and adolescents aged six to 18 years with a clinical diagnosis of CF. Sociodemographic and clinical data were collected. Sleep disorders were evaluated using baseline nocturnal polysomnography. The autonomic nervous system (ANS) was evaluated through resting HRV. Results: A total of 30 individuals (11.2 years) with a mean forced expiratory volume in the first second (FEV1) of 62.7% were included. The respiratory disturbance index presented a median of 2.6 and obstructive sleep apnea syndrome (OSAS) was identified in 30%. In the HRV analysis, a mean standard deviation of all inter-beat (RR) intervals (SDNN) of 60.8±45.9ms was found. There was a significant correlation between the HRV low-frequency/high-frequency (LF/HF) global modulation index and the minimum SpO2 during sleep in patients with FEV1<60% (r=0.71; p=0.02). The prevalence of sleep disorders and HRV abnormalities was higher in individuals with lesser pulmonary function (FEV1<60%). Conclusions: The results indicate a weak correlation of sleep disorders (minimum SpO2) with HRV parameters (LH/HF) in children and adolescents with CF. When pulmonary function was reduced, a stronger correlation was found, highlighting the influence of disease severity. A high prevalence of ANS disorders, nocturnal hypoxemia, and presence of OSAS was also found. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822022000100411 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822022000100411 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1984-0462/2022/40/2020295 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade de Pediatria de São Paulo |
publisher.none.fl_str_mv |
Sociedade de Pediatria de São Paulo |
dc.source.none.fl_str_mv |
Revista Paulista de Pediatria v.40 2022 reponame:Revista Paulista de Pediatria (Ed. Português. Online) instname:Sociedade de Pediatria de São Paulo (SPSP) instacron:SPSP |
instname_str |
Sociedade de Pediatria de São Paulo (SPSP) |
instacron_str |
SPSP |
institution |
SPSP |
reponame_str |
Revista Paulista de Pediatria (Ed. Português. Online) |
collection |
Revista Paulista de Pediatria (Ed. Português. Online) |
repository.name.fl_str_mv |
Revista Paulista de Pediatria (Ed. Português. Online) - Sociedade de Pediatria de São Paulo (SPSP) |
repository.mail.fl_str_mv |
pediatria@spsp.org.br||rpp@spsp.org.br |
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1750318252439896064 |