The effect of losartan on angiotensin II-induced cell proliferation in a rat aorta smooth muscle cell line
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Archives of Biology and Technology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000200012 |
Resumo: | The success of revascularization procedures is limited by recurrent stenosis, which is a narrowing of a blood vessels that results from neo-intimal hyperplasia. The renin-angiotensin-aldosterone system has been implicated in the pathogenesis of neo-intimal hyperplasia, and a role for angiotensin II in vascular smooth muscle cell proliferation has been proposed. There are at least two high-affinity subtypes of angiotensin II receptors, AT1 and AT2, both of which are seven-transmembrane G protein-coupled receptors. We investigated the effect of losartan, an AT1 receptor antagonist, on vascular smooth muscle cell proliferation using the A7r5 smooth cell line derived from rat aorta. Losartan was shown to prevent angiotensin II-induced cell proliferation, thereby suggesting that the effect of angiotensin II was mediated via AT1 receptors. These data strengthen the concept that inhibitors of the renin-angiotensin system can effectively prevent recurrent stenosis. |
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Brazilian Archives of Biology and Technology |
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The effect of losartan on angiotensin II-induced cell proliferation in a rat aorta smooth muscle cell lineAngiotensin IILosartanCell proliferationThe success of revascularization procedures is limited by recurrent stenosis, which is a narrowing of a blood vessels that results from neo-intimal hyperplasia. The renin-angiotensin-aldosterone system has been implicated in the pathogenesis of neo-intimal hyperplasia, and a role for angiotensin II in vascular smooth muscle cell proliferation has been proposed. There are at least two high-affinity subtypes of angiotensin II receptors, AT1 and AT2, both of which are seven-transmembrane G protein-coupled receptors. We investigated the effect of losartan, an AT1 receptor antagonist, on vascular smooth muscle cell proliferation using the A7r5 smooth cell line derived from rat aorta. Losartan was shown to prevent angiotensin II-induced cell proliferation, thereby suggesting that the effect of angiotensin II was mediated via AT1 receptors. These data strengthen the concept that inhibitors of the renin-angiotensin system can effectively prevent recurrent stenosis.Instituto de Tecnologia do Paraná - Tecpar2012-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000200012Brazilian Archives of Biology and Technology v.55 n.2 2012reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-89132012000200012info:eu-repo/semantics/openAccessTambelline,NatáliaOliveira,KarenOlchanheski Junior,Luiz RenatoSordi,ReginaOtuki,Michel FleithFavero,Giovani MarinoFernandes,Danieleng2012-05-03T00:00:00Zoai:scielo:S1516-89132012000200012Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2012-05-03T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false |
dc.title.none.fl_str_mv |
The effect of losartan on angiotensin II-induced cell proliferation in a rat aorta smooth muscle cell line |
title |
The effect of losartan on angiotensin II-induced cell proliferation in a rat aorta smooth muscle cell line |
spellingShingle |
The effect of losartan on angiotensin II-induced cell proliferation in a rat aorta smooth muscle cell line Tambelline,Natália Angiotensin II Losartan Cell proliferation |
title_short |
The effect of losartan on angiotensin II-induced cell proliferation in a rat aorta smooth muscle cell line |
title_full |
The effect of losartan on angiotensin II-induced cell proliferation in a rat aorta smooth muscle cell line |
title_fullStr |
The effect of losartan on angiotensin II-induced cell proliferation in a rat aorta smooth muscle cell line |
title_full_unstemmed |
The effect of losartan on angiotensin II-induced cell proliferation in a rat aorta smooth muscle cell line |
title_sort |
The effect of losartan on angiotensin II-induced cell proliferation in a rat aorta smooth muscle cell line |
author |
Tambelline,Natália |
author_facet |
Tambelline,Natália Oliveira,Karen Olchanheski Junior,Luiz Renato Sordi,Regina Otuki,Michel Fleith Favero,Giovani Marino Fernandes,Daniel |
author_role |
author |
author2 |
Oliveira,Karen Olchanheski Junior,Luiz Renato Sordi,Regina Otuki,Michel Fleith Favero,Giovani Marino Fernandes,Daniel |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Tambelline,Natália Oliveira,Karen Olchanheski Junior,Luiz Renato Sordi,Regina Otuki,Michel Fleith Favero,Giovani Marino Fernandes,Daniel |
dc.subject.por.fl_str_mv |
Angiotensin II Losartan Cell proliferation |
topic |
Angiotensin II Losartan Cell proliferation |
description |
The success of revascularization procedures is limited by recurrent stenosis, which is a narrowing of a blood vessels that results from neo-intimal hyperplasia. The renin-angiotensin-aldosterone system has been implicated in the pathogenesis of neo-intimal hyperplasia, and a role for angiotensin II in vascular smooth muscle cell proliferation has been proposed. There are at least two high-affinity subtypes of angiotensin II receptors, AT1 and AT2, both of which are seven-transmembrane G protein-coupled receptors. We investigated the effect of losartan, an AT1 receptor antagonist, on vascular smooth muscle cell proliferation using the A7r5 smooth cell line derived from rat aorta. Losartan was shown to prevent angiotensin II-induced cell proliferation, thereby suggesting that the effect of angiotensin II was mediated via AT1 receptors. These data strengthen the concept that inhibitors of the renin-angiotensin system can effectively prevent recurrent stenosis. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000200012 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000200012 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1516-89132012000200012 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
dc.source.none.fl_str_mv |
Brazilian Archives of Biology and Technology v.55 n.2 2012 reponame:Brazilian Archives of Biology and Technology instname:Instituto de Tecnologia do Paraná (Tecpar) instacron:TECPAR |
instname_str |
Instituto de Tecnologia do Paraná (Tecpar) |
instacron_str |
TECPAR |
institution |
TECPAR |
reponame_str |
Brazilian Archives of Biology and Technology |
collection |
Brazilian Archives of Biology and Technology |
repository.name.fl_str_mv |
Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar) |
repository.mail.fl_str_mv |
babt@tecpar.br||babt@tecpar.br |
_version_ |
1750318275186655232 |