Green Tropical Phytoextracts - Promising Anticancer Alternative

Detalhes bibliográficos
Autor(a) principal: Khan,Abid Ali
Data de Publicação: 2016
Outros Autores: Omer,Kosar Ali, Talib,Ayesha, Ahmed,Haroon, Javed,Mohamad Arshad, Sarmidi,Roji Mohamad
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Archives of Biology and Technology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132016000100328
Resumo: ABSTRACT The anticancer potential of aqueous extracts of tropical plants Ficus deltoidea and Labisia pumila were tested on human prostate carcinoma (DU145) cells. The effects of these extracts on the cells were observed through several tests such as cytotoxicity MTT assay, trypan blue exclusion assay (for cell viability), fluorescence and morphological observations. Both of the plant extracts had a growth repression effect on the cells with different concentrations. The best concentration (1x10-3 μg/mL) was chosen by determining their cytotoxic effects on human prostate cancer as well as fibroblast (normal) cells. The F. deltoidea extract showed more potency and killed the cells faster than L. pumila. Morphologically both extracts affected the cells in a similar way, i.e. the cells became irregular shaped, detached themselves and kept floating in the medium.
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spelling Green Tropical Phytoextracts - Promising Anticancer AlternativeLabisia pumilaFicus deltoideaAnticancer Plant ExtractProstate cancer.ABSTRACT The anticancer potential of aqueous extracts of tropical plants Ficus deltoidea and Labisia pumila were tested on human prostate carcinoma (DU145) cells. The effects of these extracts on the cells were observed through several tests such as cytotoxicity MTT assay, trypan blue exclusion assay (for cell viability), fluorescence and morphological observations. Both of the plant extracts had a growth repression effect on the cells with different concentrations. The best concentration (1x10-3 μg/mL) was chosen by determining their cytotoxic effects on human prostate cancer as well as fibroblast (normal) cells. The F. deltoidea extract showed more potency and killed the cells faster than L. pumila. Morphologically both extracts affected the cells in a similar way, i.e. the cells became irregular shaped, detached themselves and kept floating in the medium.Instituto de Tecnologia do Paraná - Tecpar2016-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132016000100328Brazilian Archives of Biology and Technology v.59 2016reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/1678-4324-2016160062info:eu-repo/semantics/openAccessKhan,Abid AliOmer,Kosar AliTalib,AyeshaAhmed,HaroonJaved,Mohamad ArshadSarmidi,Roji Mohamadeng2017-01-20T00:00:00Zoai:scielo:S1516-89132016000100328Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2017-01-20T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false
dc.title.none.fl_str_mv Green Tropical Phytoextracts - Promising Anticancer Alternative
title Green Tropical Phytoextracts - Promising Anticancer Alternative
spellingShingle Green Tropical Phytoextracts - Promising Anticancer Alternative
Khan,Abid Ali
Labisia pumila
Ficus deltoidea
Anticancer Plant Extract
Prostate cancer.
title_short Green Tropical Phytoextracts - Promising Anticancer Alternative
title_full Green Tropical Phytoextracts - Promising Anticancer Alternative
title_fullStr Green Tropical Phytoextracts - Promising Anticancer Alternative
title_full_unstemmed Green Tropical Phytoextracts - Promising Anticancer Alternative
title_sort Green Tropical Phytoextracts - Promising Anticancer Alternative
author Khan,Abid Ali
author_facet Khan,Abid Ali
Omer,Kosar Ali
Talib,Ayesha
Ahmed,Haroon
Javed,Mohamad Arshad
Sarmidi,Roji Mohamad
author_role author
author2 Omer,Kosar Ali
Talib,Ayesha
Ahmed,Haroon
Javed,Mohamad Arshad
Sarmidi,Roji Mohamad
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Khan,Abid Ali
Omer,Kosar Ali
Talib,Ayesha
Ahmed,Haroon
Javed,Mohamad Arshad
Sarmidi,Roji Mohamad
dc.subject.por.fl_str_mv Labisia pumila
Ficus deltoidea
Anticancer Plant Extract
Prostate cancer.
topic Labisia pumila
Ficus deltoidea
Anticancer Plant Extract
Prostate cancer.
description ABSTRACT The anticancer potential of aqueous extracts of tropical plants Ficus deltoidea and Labisia pumila were tested on human prostate carcinoma (DU145) cells. The effects of these extracts on the cells were observed through several tests such as cytotoxicity MTT assay, trypan blue exclusion assay (for cell viability), fluorescence and morphological observations. Both of the plant extracts had a growth repression effect on the cells with different concentrations. The best concentration (1x10-3 μg/mL) was chosen by determining their cytotoxic effects on human prostate cancer as well as fibroblast (normal) cells. The F. deltoidea extract showed more potency and killed the cells faster than L. pumila. Morphologically both extracts affected the cells in a similar way, i.e. the cells became irregular shaped, detached themselves and kept floating in the medium.
publishDate 2016
dc.date.none.fl_str_mv 2016-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132016000100328
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132016000100328
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1678-4324-2016160062
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
dc.source.none.fl_str_mv Brazilian Archives of Biology and Technology v.59 2016
reponame:Brazilian Archives of Biology and Technology
instname:Instituto de Tecnologia do Paraná (Tecpar)
instacron:TECPAR
instname_str Instituto de Tecnologia do Paraná (Tecpar)
instacron_str TECPAR
institution TECPAR
reponame_str Brazilian Archives of Biology and Technology
collection Brazilian Archives of Biology and Technology
repository.name.fl_str_mv Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)
repository.mail.fl_str_mv babt@tecpar.br||babt@tecpar.br
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