Biodistribution of free 99mTc-ovalbumin and 99mTc-ovalbumin encapsulated in liposomes
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Archives of Biology and Technology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700035 |
Resumo: | The oral administration of proteic antigens, like ovalbumin, may result in the induction of oral tolerance or immunization. The aim of this work was to label a protein antigen with 99mTechnetium, encapsulate it in liposomes and investigate its absorption and tissue distribution after oral administration in mice. Ovalbumin was labeled with 99mTechnetium and encapsulated in small unilamellar vesicles. 99mTc-OVA encapsulated or not in liposomes was administrated to mice that were sacrificed after different times. The radioactivity was measured in various organs of the animals. Differences concerning the biodistribution of 99mTc-OVA were noticed. The technique may represent alternatives for the induction of immunization or oral tolerance. |
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Brazilian Archives of Biology and Technology |
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Biodistribution of free 99mTc-ovalbumin and 99mTc-ovalbumin encapsulated in liposomesLiposomesoral absorptionmucosal deliveryproteinsnanotechnologyThe oral administration of proteic antigens, like ovalbumin, may result in the induction of oral tolerance or immunization. The aim of this work was to label a protein antigen with 99mTechnetium, encapsulate it in liposomes and investigate its absorption and tissue distribution after oral administration in mice. Ovalbumin was labeled with 99mTechnetium and encapsulated in small unilamellar vesicles. 99mTc-OVA encapsulated or not in liposomes was administrated to mice that were sacrificed after different times. The radioactivity was measured in various organs of the animals. Differences concerning the biodistribution of 99mTc-OVA were noticed. The technique may represent alternatives for the induction of immunization or oral tolerance.Instituto de Tecnologia do Paraná - Tecpar2005-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700035Brazilian Archives of Biology and Technology v.48 n.spe2 2005reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-89132005000700035info:eu-repo/semantics/openAccessAlves,Andrea CatãoGontijo,Cristiano MachadoOliveira,Mônica CristinaDiniz,Simone Odília FernandesOliveira,Flávia MárciaCardoso,Valbert NascimentoRamaldes,Gilson Andradeeng2005-12-09T00:00:00Zoai:scielo:S1516-89132005000700035Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2005-12-09T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false |
dc.title.none.fl_str_mv |
Biodistribution of free 99mTc-ovalbumin and 99mTc-ovalbumin encapsulated in liposomes |
title |
Biodistribution of free 99mTc-ovalbumin and 99mTc-ovalbumin encapsulated in liposomes |
spellingShingle |
Biodistribution of free 99mTc-ovalbumin and 99mTc-ovalbumin encapsulated in liposomes Alves,Andrea Catão Liposomes oral absorption mucosal delivery proteins nanotechnology |
title_short |
Biodistribution of free 99mTc-ovalbumin and 99mTc-ovalbumin encapsulated in liposomes |
title_full |
Biodistribution of free 99mTc-ovalbumin and 99mTc-ovalbumin encapsulated in liposomes |
title_fullStr |
Biodistribution of free 99mTc-ovalbumin and 99mTc-ovalbumin encapsulated in liposomes |
title_full_unstemmed |
Biodistribution of free 99mTc-ovalbumin and 99mTc-ovalbumin encapsulated in liposomes |
title_sort |
Biodistribution of free 99mTc-ovalbumin and 99mTc-ovalbumin encapsulated in liposomes |
author |
Alves,Andrea Catão |
author_facet |
Alves,Andrea Catão Gontijo,Cristiano Machado Oliveira,Mônica Cristina Diniz,Simone Odília Fernandes Oliveira,Flávia Márcia Cardoso,Valbert Nascimento Ramaldes,Gilson Andrade |
author_role |
author |
author2 |
Gontijo,Cristiano Machado Oliveira,Mônica Cristina Diniz,Simone Odília Fernandes Oliveira,Flávia Márcia Cardoso,Valbert Nascimento Ramaldes,Gilson Andrade |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Alves,Andrea Catão Gontijo,Cristiano Machado Oliveira,Mônica Cristina Diniz,Simone Odília Fernandes Oliveira,Flávia Márcia Cardoso,Valbert Nascimento Ramaldes,Gilson Andrade |
dc.subject.por.fl_str_mv |
Liposomes oral absorption mucosal delivery proteins nanotechnology |
topic |
Liposomes oral absorption mucosal delivery proteins nanotechnology |
description |
The oral administration of proteic antigens, like ovalbumin, may result in the induction of oral tolerance or immunization. The aim of this work was to label a protein antigen with 99mTechnetium, encapsulate it in liposomes and investigate its absorption and tissue distribution after oral administration in mice. Ovalbumin was labeled with 99mTechnetium and encapsulated in small unilamellar vesicles. 99mTc-OVA encapsulated or not in liposomes was administrated to mice that were sacrificed after different times. The radioactivity was measured in various organs of the animals. Differences concerning the biodistribution of 99mTc-OVA were noticed. The technique may represent alternatives for the induction of immunization or oral tolerance. |
publishDate |
2005 |
dc.date.none.fl_str_mv |
2005-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700035 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700035 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1516-89132005000700035 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
dc.source.none.fl_str_mv |
Brazilian Archives of Biology and Technology v.48 n.spe2 2005 reponame:Brazilian Archives of Biology and Technology instname:Instituto de Tecnologia do Paraná (Tecpar) instacron:TECPAR |
instname_str |
Instituto de Tecnologia do Paraná (Tecpar) |
instacron_str |
TECPAR |
institution |
TECPAR |
reponame_str |
Brazilian Archives of Biology and Technology |
collection |
Brazilian Archives of Biology and Technology |
repository.name.fl_str_mv |
Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar) |
repository.mail.fl_str_mv |
babt@tecpar.br||babt@tecpar.br |
_version_ |
1750318270701895680 |