FDOPA-(18F): a PET radiopharmaceutical recently registered for diagnostic use in countries of the European Union
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Archives of Biology and Technology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000600009 |
Resumo: | Positron emission tomography (PET) and its recent update PET/CT are very effective diagnostic tools for non-invasive imaging of metabolic or functional disorders in target tissues. The clinical usefulness of fluorodeoxyglucose-(18F) (FDG) has been now widely accepted. Recently, the clinical usefulness of fluoroDOPA-(18F) or FDOPA, an aminoacid labelled with the same positron emitter fluorine-18, has been evaluated and recognised in France and subsequently in several EU countries. FDOPA is diagnostic PET agent, which has been used for decades in imaging the loss of dopaminergic neurons in Parkinson's disease, and more recently to detect, stage and restage neuroendocrine tumours and to search for recurrence of viable glioma tissue. The present article summarises the body of evidence that led the French Medicines Agency (AFSSAPS) to grant a marketing authorisation to IASOdopa, a commercial preparation of FDOPA. Brief case reports and figures illustrate the diagnostic performance of FDOPA PET or PET/CT in the different settings that are currently approved in oncology. |
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FDOPA-(18F): a PET radiopharmaceutical recently registered for diagnostic use in countries of the European UnionRegistration of radiopharmaceuticalsPETFDOPAParkinson's diseasecancerPositron emission tomography (PET) and its recent update PET/CT are very effective diagnostic tools for non-invasive imaging of metabolic or functional disorders in target tissues. The clinical usefulness of fluorodeoxyglucose-(18F) (FDG) has been now widely accepted. Recently, the clinical usefulness of fluoroDOPA-(18F) or FDOPA, an aminoacid labelled with the same positron emitter fluorine-18, has been evaluated and recognised in France and subsequently in several EU countries. FDOPA is diagnostic PET agent, which has been used for decades in imaging the loss of dopaminergic neurons in Parkinson's disease, and more recently to detect, stage and restage neuroendocrine tumours and to search for recurrence of viable glioma tissue. The present article summarises the body of evidence that led the French Medicines Agency (AFSSAPS) to grant a marketing authorisation to IASOdopa, a commercial preparation of FDOPA. Brief case reports and figures illustrate the diagnostic performance of FDOPA PET or PET/CT in the different settings that are currently approved in oncology.Instituto de Tecnologia do Paraná - Tecpar2007-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000600009Brazilian Archives of Biology and Technology v.50 n.spe 2007reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-89132007000600009info:eu-repo/semantics/openAccessChevalme,Yanna-MarinaMontravers,FrançoiseVuillez,Jean-PhilippeZanca,MichelFallais,CharlesOustrin,JeanTalbot,Jean-Noëleng2008-03-12T00:00:00Zoai:scielo:S1516-89132007000600009Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2008-03-12T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false |
dc.title.none.fl_str_mv |
FDOPA-(18F): a PET radiopharmaceutical recently registered for diagnostic use in countries of the European Union |
title |
FDOPA-(18F): a PET radiopharmaceutical recently registered for diagnostic use in countries of the European Union |
spellingShingle |
FDOPA-(18F): a PET radiopharmaceutical recently registered for diagnostic use in countries of the European Union Chevalme,Yanna-Marina Registration of radiopharmaceuticals PET FDOPA Parkinson's disease cancer |
title_short |
FDOPA-(18F): a PET radiopharmaceutical recently registered for diagnostic use in countries of the European Union |
title_full |
FDOPA-(18F): a PET radiopharmaceutical recently registered for diagnostic use in countries of the European Union |
title_fullStr |
FDOPA-(18F): a PET radiopharmaceutical recently registered for diagnostic use in countries of the European Union |
title_full_unstemmed |
FDOPA-(18F): a PET radiopharmaceutical recently registered for diagnostic use in countries of the European Union |
title_sort |
FDOPA-(18F): a PET radiopharmaceutical recently registered for diagnostic use in countries of the European Union |
author |
Chevalme,Yanna-Marina |
author_facet |
Chevalme,Yanna-Marina Montravers,Françoise Vuillez,Jean-Philippe Zanca,Michel Fallais,Charles Oustrin,Jean Talbot,Jean-Noël |
author_role |
author |
author2 |
Montravers,Françoise Vuillez,Jean-Philippe Zanca,Michel Fallais,Charles Oustrin,Jean Talbot,Jean-Noël |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Chevalme,Yanna-Marina Montravers,Françoise Vuillez,Jean-Philippe Zanca,Michel Fallais,Charles Oustrin,Jean Talbot,Jean-Noël |
dc.subject.por.fl_str_mv |
Registration of radiopharmaceuticals PET FDOPA Parkinson's disease cancer |
topic |
Registration of radiopharmaceuticals PET FDOPA Parkinson's disease cancer |
description |
Positron emission tomography (PET) and its recent update PET/CT are very effective diagnostic tools for non-invasive imaging of metabolic or functional disorders in target tissues. The clinical usefulness of fluorodeoxyglucose-(18F) (FDG) has been now widely accepted. Recently, the clinical usefulness of fluoroDOPA-(18F) or FDOPA, an aminoacid labelled with the same positron emitter fluorine-18, has been evaluated and recognised in France and subsequently in several EU countries. FDOPA is diagnostic PET agent, which has been used for decades in imaging the loss of dopaminergic neurons in Parkinson's disease, and more recently to detect, stage and restage neuroendocrine tumours and to search for recurrence of viable glioma tissue. The present article summarises the body of evidence that led the French Medicines Agency (AFSSAPS) to grant a marketing authorisation to IASOdopa, a commercial preparation of FDOPA. Brief case reports and figures illustrate the diagnostic performance of FDOPA PET or PET/CT in the different settings that are currently approved in oncology. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000600009 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000600009 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1516-89132007000600009 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
dc.source.none.fl_str_mv |
Brazilian Archives of Biology and Technology v.50 n.spe 2007 reponame:Brazilian Archives of Biology and Technology instname:Instituto de Tecnologia do Paraná (Tecpar) instacron:TECPAR |
instname_str |
Instituto de Tecnologia do Paraná (Tecpar) |
instacron_str |
TECPAR |
institution |
TECPAR |
reponame_str |
Brazilian Archives of Biology and Technology |
collection |
Brazilian Archives of Biology and Technology |
repository.name.fl_str_mv |
Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar) |
repository.mail.fl_str_mv |
babt@tecpar.br||babt@tecpar.br |
_version_ |
1750318271846940672 |