Preparation of pellets containing highly soluble drug by extrusion/spheronisation and coating with Kollicoat® SR 30D

Detalhes bibliográficos
Autor(a) principal: Andreazza,Itamar Francisco
Data de Publicação: 2011
Outros Autores: Ferraz,Humberto Gomes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Archives of Biology and Technology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000200013
Resumo: The aim of this study was to prepare and evaluate the pellets, containing a highly soluble drug (ascorbic acid), by the extrusion-spheronization process and coated with a release controlling polymer. The coating (undertaken in a fluid bed) was applied to three batches of the pellets with a dispersion of Kollicoat® SR 30 D, with each batch of pellets receiving a different level of polymer (5.07; 8.26 and 10.35%). The coated pellets were evaluated for sphericity by imaging analysis and comparative dissolution profile with a product commercially available in Brazil. All of the evaluated samples presented adequate physical properties and the dissolution profile of those coated with 5.07% of polymer proved to be similar to that of the commercially available brand name.
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spelling Preparation of pellets containing highly soluble drug by extrusion/spheronisation and coating with Kollicoat® SR 30Dcoatingpelletsextrusion spheronizationcontrolled releaseThe aim of this study was to prepare and evaluate the pellets, containing a highly soluble drug (ascorbic acid), by the extrusion-spheronization process and coated with a release controlling polymer. The coating (undertaken in a fluid bed) was applied to three batches of the pellets with a dispersion of Kollicoat® SR 30 D, with each batch of pellets receiving a different level of polymer (5.07; 8.26 and 10.35%). The coated pellets were evaluated for sphericity by imaging analysis and comparative dissolution profile with a product commercially available in Brazil. All of the evaluated samples presented adequate physical properties and the dissolution profile of those coated with 5.07% of polymer proved to be similar to that of the commercially available brand name.Instituto de Tecnologia do Paraná - Tecpar2011-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000200013Brazilian Archives of Biology and Technology v.54 n.2 2011reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-89132011000200013info:eu-repo/semantics/openAccessAndreazza,Itamar FranciscoFerraz,Humberto Gomeseng2011-04-15T00:00:00Zoai:scielo:S1516-89132011000200013Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2011-04-15T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false
dc.title.none.fl_str_mv Preparation of pellets containing highly soluble drug by extrusion/spheronisation and coating with Kollicoat® SR 30D
title Preparation of pellets containing highly soluble drug by extrusion/spheronisation and coating with Kollicoat® SR 30D
spellingShingle Preparation of pellets containing highly soluble drug by extrusion/spheronisation and coating with Kollicoat® SR 30D
Andreazza,Itamar Francisco
coating
pellets
extrusion spheronization
controlled release
title_short Preparation of pellets containing highly soluble drug by extrusion/spheronisation and coating with Kollicoat® SR 30D
title_full Preparation of pellets containing highly soluble drug by extrusion/spheronisation and coating with Kollicoat® SR 30D
title_fullStr Preparation of pellets containing highly soluble drug by extrusion/spheronisation and coating with Kollicoat® SR 30D
title_full_unstemmed Preparation of pellets containing highly soluble drug by extrusion/spheronisation and coating with Kollicoat® SR 30D
title_sort Preparation of pellets containing highly soluble drug by extrusion/spheronisation and coating with Kollicoat® SR 30D
author Andreazza,Itamar Francisco
author_facet Andreazza,Itamar Francisco
Ferraz,Humberto Gomes
author_role author
author2 Ferraz,Humberto Gomes
author2_role author
dc.contributor.author.fl_str_mv Andreazza,Itamar Francisco
Ferraz,Humberto Gomes
dc.subject.por.fl_str_mv coating
pellets
extrusion spheronization
controlled release
topic coating
pellets
extrusion spheronization
controlled release
description The aim of this study was to prepare and evaluate the pellets, containing a highly soluble drug (ascorbic acid), by the extrusion-spheronization process and coated with a release controlling polymer. The coating (undertaken in a fluid bed) was applied to three batches of the pellets with a dispersion of Kollicoat® SR 30 D, with each batch of pellets receiving a different level of polymer (5.07; 8.26 and 10.35%). The coated pellets were evaluated for sphericity by imaging analysis and comparative dissolution profile with a product commercially available in Brazil. All of the evaluated samples presented adequate physical properties and the dissolution profile of those coated with 5.07% of polymer proved to be similar to that of the commercially available brand name.
publishDate 2011
dc.date.none.fl_str_mv 2011-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000200013
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000200013
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-89132011000200013
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
dc.source.none.fl_str_mv Brazilian Archives of Biology and Technology v.54 n.2 2011
reponame:Brazilian Archives of Biology and Technology
instname:Instituto de Tecnologia do Paraná (Tecpar)
instacron:TECPAR
instname_str Instituto de Tecnologia do Paraná (Tecpar)
instacron_str TECPAR
institution TECPAR
reponame_str Brazilian Archives of Biology and Technology
collection Brazilian Archives of Biology and Technology
repository.name.fl_str_mv Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)
repository.mail.fl_str_mv babt@tecpar.br||babt@tecpar.br
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