Vitamin E and Sodium Selenite Against Mercuric Chloride-Induced Lung Toxicity in the Rats

Detalhes bibliográficos
Autor(a) principal: Celikoglu,Emine
Data de Publicação: 2015
Outros Autores: Aslanturk,Ayse, Kalender,Yusuf
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Archives of Biology and Technology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000400587
Resumo: The aim of the present study was to elucidate the possible protective role of vitamin E and / or sodium selenite on mercuric chloride-induced oxidative stress and histopathological changes in the lung tissue of the rats. Adult male albino Wistar rats were exposed to mercuric chloride (1.0 mg/kg day) for four weeks. Treatment with mercuric chloride led to oxidative stress by enhancing MDA level and also decreasing superoxide dismutase (SOD), catalase (CAT) glutathione peroxidase (GPx) and glutathione S transferaz (GST) activities. However, mercuric chloride exposure resulted in histopathological changes in the lung tissue in the rats. MDA level and SOD, CAT GPx and GST activities and histopathological changes modulated in concomitantly supplementation of vitamin E (100 mg/kg day) and /or sodium selenite (0.25 mg/kg day) to mercuric chloride-treated groups.
id TECPAR-1_5a95c899168dc5cf753e89d0d8991a07
oai_identifier_str oai:scielo:S1516-89132015000400587
network_acronym_str TECPAR-1
network_name_str Brazilian Archives of Biology and Technology
repository_id_str
spelling Vitamin E and Sodium Selenite Against Mercuric Chloride-Induced Lung Toxicity in the RatsMercuric chlorideSodium seleniteVitamin ELung toxicityOxidative stressHistopathologyThe aim of the present study was to elucidate the possible protective role of vitamin E and / or sodium selenite on mercuric chloride-induced oxidative stress and histopathological changes in the lung tissue of the rats. Adult male albino Wistar rats were exposed to mercuric chloride (1.0 mg/kg day) for four weeks. Treatment with mercuric chloride led to oxidative stress by enhancing MDA level and also decreasing superoxide dismutase (SOD), catalase (CAT) glutathione peroxidase (GPx) and glutathione S transferaz (GST) activities. However, mercuric chloride exposure resulted in histopathological changes in the lung tissue in the rats. MDA level and SOD, CAT GPx and GST activities and histopathological changes modulated in concomitantly supplementation of vitamin E (100 mg/kg day) and /or sodium selenite (0.25 mg/kg day) to mercuric chloride-treated groups.Instituto de Tecnologia do Paraná - Tecpar2015-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000400587Brazilian Archives of Biology and Technology v.58 n.4 2015reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-8913201500098info:eu-repo/semantics/openAccessCelikoglu,EmineAslanturk,AyseKalender,Yusufeng2015-10-26T00:00:00Zoai:scielo:S1516-89132015000400587Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2015-10-26T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false
dc.title.none.fl_str_mv Vitamin E and Sodium Selenite Against Mercuric Chloride-Induced Lung Toxicity in the Rats
title Vitamin E and Sodium Selenite Against Mercuric Chloride-Induced Lung Toxicity in the Rats
spellingShingle Vitamin E and Sodium Selenite Against Mercuric Chloride-Induced Lung Toxicity in the Rats
Celikoglu,Emine
Mercuric chloride
Sodium selenite
Vitamin E
Lung toxicity
Oxidative stress
Histopathology
title_short Vitamin E and Sodium Selenite Against Mercuric Chloride-Induced Lung Toxicity in the Rats
title_full Vitamin E and Sodium Selenite Against Mercuric Chloride-Induced Lung Toxicity in the Rats
title_fullStr Vitamin E and Sodium Selenite Against Mercuric Chloride-Induced Lung Toxicity in the Rats
title_full_unstemmed Vitamin E and Sodium Selenite Against Mercuric Chloride-Induced Lung Toxicity in the Rats
title_sort Vitamin E and Sodium Selenite Against Mercuric Chloride-Induced Lung Toxicity in the Rats
author Celikoglu,Emine
author_facet Celikoglu,Emine
Aslanturk,Ayse
Kalender,Yusuf
author_role author
author2 Aslanturk,Ayse
Kalender,Yusuf
author2_role author
author
dc.contributor.author.fl_str_mv Celikoglu,Emine
Aslanturk,Ayse
Kalender,Yusuf
dc.subject.por.fl_str_mv Mercuric chloride
Sodium selenite
Vitamin E
Lung toxicity
Oxidative stress
Histopathology
topic Mercuric chloride
Sodium selenite
Vitamin E
Lung toxicity
Oxidative stress
Histopathology
description The aim of the present study was to elucidate the possible protective role of vitamin E and / or sodium selenite on mercuric chloride-induced oxidative stress and histopathological changes in the lung tissue of the rats. Adult male albino Wistar rats were exposed to mercuric chloride (1.0 mg/kg day) for four weeks. Treatment with mercuric chloride led to oxidative stress by enhancing MDA level and also decreasing superoxide dismutase (SOD), catalase (CAT) glutathione peroxidase (GPx) and glutathione S transferaz (GST) activities. However, mercuric chloride exposure resulted in histopathological changes in the lung tissue in the rats. MDA level and SOD, CAT GPx and GST activities and histopathological changes modulated in concomitantly supplementation of vitamin E (100 mg/kg day) and /or sodium selenite (0.25 mg/kg day) to mercuric chloride-treated groups.
publishDate 2015
dc.date.none.fl_str_mv 2015-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000400587
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000400587
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-8913201500098
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
dc.source.none.fl_str_mv Brazilian Archives of Biology and Technology v.58 n.4 2015
reponame:Brazilian Archives of Biology and Technology
instname:Instituto de Tecnologia do Paraná (Tecpar)
instacron:TECPAR
instname_str Instituto de Tecnologia do Paraná (Tecpar)
instacron_str TECPAR
institution TECPAR
reponame_str Brazilian Archives of Biology and Technology
collection Brazilian Archives of Biology and Technology
repository.name.fl_str_mv Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)
repository.mail.fl_str_mv babt@tecpar.br||babt@tecpar.br
_version_ 1750318276938825728

Registros relacionados