Extracts of red yolk from duck eggs inhibit metastasis of human mammary carcinoma (4T1) cells in mice

• Autor(a) principal: Qi-bin,Song
• Data de Publicação: 2011
• Outros Autores: Yi,Yao, Wei-guo,Hu, Sheng-hua,Zhang, Xiao-wei,Yan, Rui,Yang
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Brazilian Archives of Biology and Technology
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000300011
• topic: duck egg yolk; extracts; mammary carcinoma; metastasis; 4T1 Cells; BALB/c mice

The aim of the present study was to investigate the in vivo anti-metastatic activity of the red pigments of red yolk eggs laid by the ducks dieting on Potamogeton cripus L on the mammary carcinoma (4T1). The pigments were extracted with petroleum ether and acetone (2:1, v/v). BALB/c mice were divided into three groups (n=6), fed with the extracts at 150 mg/kg body weight (BW)/day (DEYE-H) or at 50 mg/kg BW/day (DEYE-L) and identical buffer without the extract (control group). The extracts were administered for 34 days. The treatment significantly inhibited the growth of orthotopical 4T1 tumour (DEYE-H vs control, 1:2; DEYE-L vs control, 2:3) and reduced the metastasis of tumour in the lungs (DEYE-H vs control, 4:7; DEYE-L vs control, 5:7), without statistical difference of body weight among the three groups.