Acetylsalicylic acid and labeling of blood constituents with technetium-99m

Detalhes bibliográficos
Autor(a) principal: Fonseca,Adenilson de Souza da
Data de Publicação: 2005
Outros Autores: Frydman,Jacques Natan Grinapel, Rocha,Vanessa Câmara da, Bernardo-Filho,Mario
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Archives of Biology and Technology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700024
Resumo: Acetylsalicylic acid is the drug most used an anti-inflammatory agent and for secondary prevention of thrombotic phenomenon. Drugs can modify the labeling of blood constituents with technetium-99m (99mTc). The aim of this work was to evaluate the effect of in vitro or in vivo assays with acetylsalicylic acid on the labeling of the blood constituents with 99mTc. In vitro assay was performed with samples of whole blood from Wistar rats incubated with acetylsalicylic acid (1.0 mg/ml) for one hour before the 99mTc-labeling process. For in vivo assay, Wistar rats were treated with acetylsalicylic acid (1.5 mg/kg) during one hour, and the whole blood was withdrawn for the 99mTc-labeling process. Saline was used in control groups. Data showed that the fixation of 99mTc to the blood constituents was not significantly (p>0.05) modified in in vitro and in vivo assays with acetylsalicylic acid, at least not when the experiments were carried out with the doses normally used in human beings.
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spelling Acetylsalicylic acid and labeling of blood constituents with technetium-99mAcetylsalicylic AcidBlood ConstituentsTechnetium-99mAcetylsalicylic acid is the drug most used an anti-inflammatory agent and for secondary prevention of thrombotic phenomenon. Drugs can modify the labeling of blood constituents with technetium-99m (99mTc). The aim of this work was to evaluate the effect of in vitro or in vivo assays with acetylsalicylic acid on the labeling of the blood constituents with 99mTc. In vitro assay was performed with samples of whole blood from Wistar rats incubated with acetylsalicylic acid (1.0 mg/ml) for one hour before the 99mTc-labeling process. For in vivo assay, Wistar rats were treated with acetylsalicylic acid (1.5 mg/kg) during one hour, and the whole blood was withdrawn for the 99mTc-labeling process. Saline was used in control groups. Data showed that the fixation of 99mTc to the blood constituents was not significantly (p>0.05) modified in in vitro and in vivo assays with acetylsalicylic acid, at least not when the experiments were carried out with the doses normally used in human beings.Instituto de Tecnologia do Paraná - Tecpar2005-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700024Brazilian Archives of Biology and Technology v.48 n.spe2 2005reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-89132005000700024info:eu-repo/semantics/openAccessFonseca,Adenilson de Souza daFrydman,Jacques Natan GrinapelRocha,Vanessa Câmara daBernardo-Filho,Marioeng2005-12-09T00:00:00Zoai:scielo:S1516-89132005000700024Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2005-12-09T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false
dc.title.none.fl_str_mv Acetylsalicylic acid and labeling of blood constituents with technetium-99m
title Acetylsalicylic acid and labeling of blood constituents with technetium-99m
spellingShingle Acetylsalicylic acid and labeling of blood constituents with technetium-99m
Fonseca,Adenilson de Souza da
Acetylsalicylic Acid
Blood Constituents
Technetium-99m
title_short Acetylsalicylic acid and labeling of blood constituents with technetium-99m
title_full Acetylsalicylic acid and labeling of blood constituents with technetium-99m
title_fullStr Acetylsalicylic acid and labeling of blood constituents with technetium-99m
title_full_unstemmed Acetylsalicylic acid and labeling of blood constituents with technetium-99m
title_sort Acetylsalicylic acid and labeling of blood constituents with technetium-99m
author Fonseca,Adenilson de Souza da
author_facet Fonseca,Adenilson de Souza da
Frydman,Jacques Natan Grinapel
Rocha,Vanessa Câmara da
Bernardo-Filho,Mario
author_role author
author2 Frydman,Jacques Natan Grinapel
Rocha,Vanessa Câmara da
Bernardo-Filho,Mario
author2_role author
author
author
dc.contributor.author.fl_str_mv Fonseca,Adenilson de Souza da
Frydman,Jacques Natan Grinapel
Rocha,Vanessa Câmara da
Bernardo-Filho,Mario
dc.subject.por.fl_str_mv Acetylsalicylic Acid
Blood Constituents
Technetium-99m
topic Acetylsalicylic Acid
Blood Constituents
Technetium-99m
description Acetylsalicylic acid is the drug most used an anti-inflammatory agent and for secondary prevention of thrombotic phenomenon. Drugs can modify the labeling of blood constituents with technetium-99m (99mTc). The aim of this work was to evaluate the effect of in vitro or in vivo assays with acetylsalicylic acid on the labeling of the blood constituents with 99mTc. In vitro assay was performed with samples of whole blood from Wistar rats incubated with acetylsalicylic acid (1.0 mg/ml) for one hour before the 99mTc-labeling process. For in vivo assay, Wistar rats were treated with acetylsalicylic acid (1.5 mg/kg) during one hour, and the whole blood was withdrawn for the 99mTc-labeling process. Saline was used in control groups. Data showed that the fixation of 99mTc to the blood constituents was not significantly (p>0.05) modified in in vitro and in vivo assays with acetylsalicylic acid, at least not when the experiments were carried out with the doses normally used in human beings.
publishDate 2005
dc.date.none.fl_str_mv 2005-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700024
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700024
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-89132005000700024
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
dc.source.none.fl_str_mv Brazilian Archives of Biology and Technology v.48 n.spe2 2005
reponame:Brazilian Archives of Biology and Technology
instname:Instituto de Tecnologia do Paraná (Tecpar)
instacron:TECPAR
instname_str Instituto de Tecnologia do Paraná (Tecpar)
instacron_str TECPAR
institution TECPAR
reponame_str Brazilian Archives of Biology and Technology
collection Brazilian Archives of Biology and Technology
repository.name.fl_str_mv Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)
repository.mail.fl_str_mv babt@tecpar.br||babt@tecpar.br
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