Experimental models using radionuclides for assessment of the effects of natural drugs

• Autor(a) principal: Moreno,Silvana Ramos Farias
• Data de Publicação: 2008
• Outros Autores: Carvalho,Jorge José de, Rebello,Bernardo, Rocha,Emely Kazan, Timóteo,Margareth de Oliveira, Olej,Beni, Bernardo Filho,Mário, Caldas,Luiz Querino de Araújo
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Brazilian Archives of Biology and Technology
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700027
• topic: Nectandra membranacea (N. membranacea); Ginkgo biloba (EGb); Passiflora edulis flavicarpa (PEF); blood constituents (BC) labeling; technetium-99m; biodistribution

The aim of this study was to evaluate the effect of the extracts of Nectandra membranacea (N. membranacea), Ginkgo biloba (EGb) and Passiflora (PEF) on the morphology of red blood cells (RBC), on the biodistribution of sodium pertechnetate (99mTcO4Na), on the morphology of duodenum and on the labeling of blood constituents (BC, IF-P, IF-BC) with technetium-99m (Tc-99m). Morphometry studies also were performed. The results show that EGb promotes alteration of the labeling of BC, IF-P and IF-BC (p<0.05). The N. membranacea extract does not promote significant alteration of the radiolabeling, and PEF extract alters the IF-P labeling. N. membranacea, EGb and PEF extracts were able to alter the RBC morphology (P<0.05). N. membranacea extract and EGb modifies the biodistribution of the 99mTcO4Na, and EGb influences the morphometry of duodenum isolated from rats (P<0.05).