Dissolution profile evaluation of solid pharmaceutical forms containing chloramphenicol marketed in Brazil

Detalhes bibliográficos
Autor(a) principal: Ferraz,Humberto Gomes
Data de Publicação: 2007
Outros Autores: Carpentieri,Leticia Norma, Watanabe,Sayuri Pereira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Archives of Biology and Technology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000100007
Resumo: The dissolution profile for solid pharmaceutical forms containing chloramphenicol 250 mg available in Brazil was determined using a method from the American Pharmacopoeia (United States Pharmacopoeia, 2004) and then compared. Two different methods of dissolution profile comparison were used: ANOVA, and an independent model. Differences between the formulations were reflected in the dissolution profiles. The presence of metastable polymorphs or amorphous forms of chloramphenicol palmitate might be responsible for variations in the concentration of the drug observed within formulations.
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spelling Dissolution profile evaluation of solid pharmaceutical forms containing chloramphenicol marketed in BrazilChloramphenicolDissolutionPolymorphismThe dissolution profile for solid pharmaceutical forms containing chloramphenicol 250 mg available in Brazil was determined using a method from the American Pharmacopoeia (United States Pharmacopoeia, 2004) and then compared. Two different methods of dissolution profile comparison were used: ANOVA, and an independent model. Differences between the formulations were reflected in the dissolution profiles. The presence of metastable polymorphs or amorphous forms of chloramphenicol palmitate might be responsible for variations in the concentration of the drug observed within formulations.Instituto de Tecnologia do Paraná - Tecpar2007-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000100007Brazilian Archives of Biology and Technology v.50 n.1 2007reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-89132007000100007info:eu-repo/semantics/openAccessFerraz,Humberto GomesCarpentieri,Leticia NormaWatanabe,Sayuri Pereiraeng2007-05-30T00:00:00Zoai:scielo:S1516-89132007000100007Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2007-05-30T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false
dc.title.none.fl_str_mv Dissolution profile evaluation of solid pharmaceutical forms containing chloramphenicol marketed in Brazil
title Dissolution profile evaluation of solid pharmaceutical forms containing chloramphenicol marketed in Brazil
spellingShingle Dissolution profile evaluation of solid pharmaceutical forms containing chloramphenicol marketed in Brazil
Ferraz,Humberto Gomes
Chloramphenicol
Dissolution
Polymorphism
title_short Dissolution profile evaluation of solid pharmaceutical forms containing chloramphenicol marketed in Brazil
title_full Dissolution profile evaluation of solid pharmaceutical forms containing chloramphenicol marketed in Brazil
title_fullStr Dissolution profile evaluation of solid pharmaceutical forms containing chloramphenicol marketed in Brazil
title_full_unstemmed Dissolution profile evaluation of solid pharmaceutical forms containing chloramphenicol marketed in Brazil
title_sort Dissolution profile evaluation of solid pharmaceutical forms containing chloramphenicol marketed in Brazil
author Ferraz,Humberto Gomes
author_facet Ferraz,Humberto Gomes
Carpentieri,Leticia Norma
Watanabe,Sayuri Pereira
author_role author
author2 Carpentieri,Leticia Norma
Watanabe,Sayuri Pereira
author2_role author
author
dc.contributor.author.fl_str_mv Ferraz,Humberto Gomes
Carpentieri,Leticia Norma
Watanabe,Sayuri Pereira
dc.subject.por.fl_str_mv Chloramphenicol
Dissolution
Polymorphism
topic Chloramphenicol
Dissolution
Polymorphism
description The dissolution profile for solid pharmaceutical forms containing chloramphenicol 250 mg available in Brazil was determined using a method from the American Pharmacopoeia (United States Pharmacopoeia, 2004) and then compared. Two different methods of dissolution profile comparison were used: ANOVA, and an independent model. Differences between the formulations were reflected in the dissolution profiles. The presence of metastable polymorphs or amorphous forms of chloramphenicol palmitate might be responsible for variations in the concentration of the drug observed within formulations.
publishDate 2007
dc.date.none.fl_str_mv 2007-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000100007
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000100007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-89132007000100007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
dc.source.none.fl_str_mv Brazilian Archives of Biology and Technology v.50 n.1 2007
reponame:Brazilian Archives of Biology and Technology
instname:Instituto de Tecnologia do Paraná (Tecpar)
instacron:TECPAR
instname_str Instituto de Tecnologia do Paraná (Tecpar)
instacron_str TECPAR
institution TECPAR
reponame_str Brazilian Archives of Biology and Technology
collection Brazilian Archives of Biology and Technology
repository.name.fl_str_mv Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)
repository.mail.fl_str_mv babt@tecpar.br||babt@tecpar.br
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