Dissolution profile evaluation of solid pharmaceutical forms containing chloramphenicol marketed in Brazil

Detalhes bibliográficos
Autor(a) principal: Ferraz, Humberto Gomes
Data de Publicação: 2007
Outros Autores: Carpentieri, Leticia Norma, Watanabe, Sayuri Pereira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UnB
Texto Completo: http://repositorio.unb.br/handle/10482/27091
https://dx.doi.org/10.1590/S1516-89132007000100007
Resumo: The dissolution profile for solid pharmaceutical forms containing chloramphenicol 250 mg available in Brazil was determined using a method from the American Pharmacopoeia (United States Pharmacopoeia, 2004) and then compared. Two different methods of dissolution profile comparison were used: ANOVA, and an independent model. Differences between the formulations were reflected in the dissolution profiles. The presence of metastable polymorphs or amorphous forms of chloramphenicol palmitate might be responsible for variations in the concentration of the drug observed within formulations.
id UNB_23fcac2eb915e39a3db9c48af544fd0a
oai_identifier_str oai:repositorio.unb.br:10482/27091
network_acronym_str UNB
network_name_str Repositório Institucional da UnB
repository_id_str
spelling Dissolution profile evaluation of solid pharmaceutical forms containing chloramphenicol marketed in BrazilCloranfenicolDissoluçãoPolimorfismoThe dissolution profile for solid pharmaceutical forms containing chloramphenicol 250 mg available in Brazil was determined using a method from the American Pharmacopoeia (United States Pharmacopoeia, 2004) and then compared. Two different methods of dissolution profile comparison were used: ANOVA, and an independent model. Differences between the formulations were reflected in the dissolution profiles. The presence of metastable polymorphs or amorphous forms of chloramphenicol palmitate might be responsible for variations in the concentration of the drug observed within formulations.O perfil de dissolução de formas farmacêuticas sólidas contendo palmitato de cloranfenicol 250 mg disponíveis no Brasil foi determinada pelo método da Farmacopéia Americana (United States Pharmacopeia, 2004) e comparado. Duas categorias de métodos para comparação dos perfis de dissolução foram utilizadas: ANOVA e modelo independente. Diferenças entre as formulações foram refletidas nos perfis de dissolução. A presença de polimorfos metaestáveis ou formas amorfas de palmitato de cloranfenicol pode ser responsável pelas variações na concentração do fármaco observada nas formulações.Em processamentoInstituto de Tecnologia do Paraná - Tecpar2017-12-07T04:48:32Z2017-12-07T04:48:32Z2007info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfBraz. arch. biol. technol.,v.50,n.1,p.57-65,2007http://repositorio.unb.br/handle/10482/27091https://dx.doi.org/10.1590/S1516-89132007000100007Ferraz, Humberto GomesCarpentieri, Leticia NormaWatanabe, Sayuri Pereirainfo:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNB2024-08-28T19:04:08Zoai:repositorio.unb.br:10482/27091Repositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2024-08-28T19:04:08Repositório Institucional da UnB - Universidade de Brasília (UnB)false
dc.title.none.fl_str_mv Dissolution profile evaluation of solid pharmaceutical forms containing chloramphenicol marketed in Brazil
title Dissolution profile evaluation of solid pharmaceutical forms containing chloramphenicol marketed in Brazil
spellingShingle Dissolution profile evaluation of solid pharmaceutical forms containing chloramphenicol marketed in Brazil
Ferraz, Humberto Gomes
Cloranfenicol
Dissolução
Polimorfismo
title_short Dissolution profile evaluation of solid pharmaceutical forms containing chloramphenicol marketed in Brazil
title_full Dissolution profile evaluation of solid pharmaceutical forms containing chloramphenicol marketed in Brazil
title_fullStr Dissolution profile evaluation of solid pharmaceutical forms containing chloramphenicol marketed in Brazil
title_full_unstemmed Dissolution profile evaluation of solid pharmaceutical forms containing chloramphenicol marketed in Brazil
title_sort Dissolution profile evaluation of solid pharmaceutical forms containing chloramphenicol marketed in Brazil
author Ferraz, Humberto Gomes
author_facet Ferraz, Humberto Gomes
Carpentieri, Leticia Norma
Watanabe, Sayuri Pereira
author_role author
author2 Carpentieri, Leticia Norma
Watanabe, Sayuri Pereira
author2_role author
author
dc.contributor.author.fl_str_mv Ferraz, Humberto Gomes
Carpentieri, Leticia Norma
Watanabe, Sayuri Pereira
dc.subject.por.fl_str_mv Cloranfenicol
Dissolução
Polimorfismo
topic Cloranfenicol
Dissolução
Polimorfismo
description The dissolution profile for solid pharmaceutical forms containing chloramphenicol 250 mg available in Brazil was determined using a method from the American Pharmacopoeia (United States Pharmacopoeia, 2004) and then compared. Two different methods of dissolution profile comparison were used: ANOVA, and an independent model. Differences between the formulations were reflected in the dissolution profiles. The presence of metastable polymorphs or amorphous forms of chloramphenicol palmitate might be responsible for variations in the concentration of the drug observed within formulations.
publishDate 2007
dc.date.none.fl_str_mv 2007
2017-12-07T04:48:32Z
2017-12-07T04:48:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv Braz. arch. biol. technol.,v.50,n.1,p.57-65,2007
http://repositorio.unb.br/handle/10482/27091
https://dx.doi.org/10.1590/S1516-89132007000100007
identifier_str_mv Braz. arch. biol. technol.,v.50,n.1,p.57-65,2007
url http://repositorio.unb.br/handle/10482/27091
https://dx.doi.org/10.1590/S1516-89132007000100007
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
dc.source.none.fl_str_mv reponame:Repositório Institucional da UnB
instname:Universidade de Brasília (UnB)
instacron:UNB
instname_str Universidade de Brasília (UnB)
instacron_str UNB
institution UNB
reponame_str Repositório Institucional da UnB
collection Repositório Institucional da UnB
repository.name.fl_str_mv Repositório Institucional da UnB - Universidade de Brasília (UnB)
repository.mail.fl_str_mv repositorio@unb.br
_version_ 1814508403560546304

Registros relacionados