Influence of tetracycline in the hepatic and renal development of rat's offspring

Detalhes bibliográficos
Autor(a) principal: Machado,Ana Lourdes da Silva
Data de Publicação: 2003
Outros Autores: Brandão,Adriana Aigotti Haberbeck, Silva,Cláudia Maria de Oliveira Monteiro da, Rocha,Rosilene Fernandes da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Archives of Biology and Technology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132003000100008
Resumo: This study aimed on evaluating the possible effects of tetracycline administered to rats on the tenth day of pregnancy, on kidney and liver development of their offspring. The liver showed vacuolization, necrosis, inflammation and sinusoidal dilatations, more evident in the newborn. Mitosis, early increase of Kupffer cells population and hipertrophy of hepatocytes with greater synthesis of glycogen were present on the tenth and twentieth days of life. The kidney showed slight tubular vacuolizations and necrosis, more proeminent in the newborn, as well as signs of tubular regeneration on the tenth and twentieth days. These results suggested that the organs studied went through several transitory morphological changes during development but presented signs of regeneration along the first days of life.
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spelling Influence of tetracycline in the hepatic and renal development of rat's offspringPregnancyDevelopmentTetracyclineHepatotoxicityNephrotoxicityThis study aimed on evaluating the possible effects of tetracycline administered to rats on the tenth day of pregnancy, on kidney and liver development of their offspring. The liver showed vacuolization, necrosis, inflammation and sinusoidal dilatations, more evident in the newborn. Mitosis, early increase of Kupffer cells population and hipertrophy of hepatocytes with greater synthesis of glycogen were present on the tenth and twentieth days of life. The kidney showed slight tubular vacuolizations and necrosis, more proeminent in the newborn, as well as signs of tubular regeneration on the tenth and twentieth days. These results suggested that the organs studied went through several transitory morphological changes during development but presented signs of regeneration along the first days of life.Instituto de Tecnologia do Paraná - Tecpar2003-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132003000100008Brazilian Archives of Biology and Technology v.46 n.1 2003reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-89132003000100008info:eu-repo/semantics/openAccessMachado,Ana Lourdes da SilvaBrandão,Adriana Aigotti HaberbeckSilva,Cláudia Maria de Oliveira Monteiro daRocha,Rosilene Fernandes daeng2003-05-19T00:00:00Zoai:scielo:S1516-89132003000100008Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2003-05-19T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false
dc.title.none.fl_str_mv Influence of tetracycline in the hepatic and renal development of rat's offspring
title Influence of tetracycline in the hepatic and renal development of rat's offspring
spellingShingle Influence of tetracycline in the hepatic and renal development of rat's offspring
Machado,Ana Lourdes da Silva
Pregnancy
Development
Tetracycline
Hepatotoxicity
Nephrotoxicity
title_short Influence of tetracycline in the hepatic and renal development of rat's offspring
title_full Influence of tetracycline in the hepatic and renal development of rat's offspring
title_fullStr Influence of tetracycline in the hepatic and renal development of rat's offspring
title_full_unstemmed Influence of tetracycline in the hepatic and renal development of rat's offspring
title_sort Influence of tetracycline in the hepatic and renal development of rat's offspring
author Machado,Ana Lourdes da Silva
author_facet Machado,Ana Lourdes da Silva
Brandão,Adriana Aigotti Haberbeck
Silva,Cláudia Maria de Oliveira Monteiro da
Rocha,Rosilene Fernandes da
author_role author
author2 Brandão,Adriana Aigotti Haberbeck
Silva,Cláudia Maria de Oliveira Monteiro da
Rocha,Rosilene Fernandes da
author2_role author
author
author
dc.contributor.author.fl_str_mv Machado,Ana Lourdes da Silva
Brandão,Adriana Aigotti Haberbeck
Silva,Cláudia Maria de Oliveira Monteiro da
Rocha,Rosilene Fernandes da
dc.subject.por.fl_str_mv Pregnancy
Development
Tetracycline
Hepatotoxicity
Nephrotoxicity
topic Pregnancy
Development
Tetracycline
Hepatotoxicity
Nephrotoxicity
description This study aimed on evaluating the possible effects of tetracycline administered to rats on the tenth day of pregnancy, on kidney and liver development of their offspring. The liver showed vacuolization, necrosis, inflammation and sinusoidal dilatations, more evident in the newborn. Mitosis, early increase of Kupffer cells population and hipertrophy of hepatocytes with greater synthesis of glycogen were present on the tenth and twentieth days of life. The kidney showed slight tubular vacuolizations and necrosis, more proeminent in the newborn, as well as signs of tubular regeneration on the tenth and twentieth days. These results suggested that the organs studied went through several transitory morphological changes during development but presented signs of regeneration along the first days of life.
publishDate 2003
dc.date.none.fl_str_mv 2003-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132003000100008
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132003000100008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-89132003000100008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
dc.source.none.fl_str_mv Brazilian Archives of Biology and Technology v.46 n.1 2003
reponame:Brazilian Archives of Biology and Technology
instname:Instituto de Tecnologia do Paraná (Tecpar)
instacron:TECPAR
instname_str Instituto de Tecnologia do Paraná (Tecpar)
instacron_str TECPAR
institution TECPAR
reponame_str Brazilian Archives of Biology and Technology
collection Brazilian Archives of Biology and Technology
repository.name.fl_str_mv Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)
repository.mail.fl_str_mv babt@tecpar.br||babt@tecpar.br
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