Tepoxalin on renal function and liver enzymes in cats exposed to hypotension with isoflurane

Detalhes bibliográficos
Autor(a) principal: Freitas,Gabrielle Coelho
Data de Publicação: 2014
Outros Autores: Carregaro,Adriano Bonfim, Bisetto,Shayne Pedrozo, Barbosa,Aline Soares, Fantinato Neto,Paulo, Dellova,Deise Carla Almeida Leite, Lopes,Carlize
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Ciência Rural
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782014000600020
Resumo: This study aimed to evaluate the possible renal and hepatic toxicity of tepoxalin administered before or after isoflurane-induced hypotension, as well as for five consecutive days. Twelve healthy mixed-breed cats, adult males, weighing 4.0±0.8kg were allocated into two groups. They received 25mgkg-1 of tepoxalin orally, two hours before the anesthetic procedure (PRE) or after the procedure (POST) and daily for five days. Cats were anesthetized with isoflurane and the concentration was increased until mean arterial pressure reached 40-60mmHg and kept at this level for 60 minutes. During hypotension, the physiological variables were measured at time 0 and every 10 minutes until 60 minutes, and bleeding time was measured at time 0, 30 and 60 minutes. Blood samples were drawn for a hemogram and determination of concentrations of alanine aminotransferase, alkaline phosphatase, urea, creatinine and Na+ at baseline, 24 hours, 48 hours and 7 days post-hypotension. Urine was collected at baseline, 24 hours, 48 hours and 7 days post-hypotension for determination of concentrations of creatinine, gamma-glutamyltransferase, urine specific gravity, protein, albumin and Na+. During the anesthetic procedure there were no important variations in physiological variables and bleeding time. There were differences only in fractional excretion of Na+, which was elevated at 7 days of evaluation in PRE and in the urine protein/creatinine ratio in PRE, which was higher than in POST at 24 and 48 hours post-hypotension. We conclude that tepoxalin does not cause alterations in hepatic enzymes but can cause discrete renal injury, resulting in proteinuria, in cats subjected to 60min of hypotension.
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spelling Tepoxalin on renal function and liver enzymes in cats exposed to hypotension with isofluranenon-steroidal anti-inflammatory drugnephrotoxicityhepatotoxicityThis study aimed to evaluate the possible renal and hepatic toxicity of tepoxalin administered before or after isoflurane-induced hypotension, as well as for five consecutive days. Twelve healthy mixed-breed cats, adult males, weighing 4.0±0.8kg were allocated into two groups. They received 25mgkg-1 of tepoxalin orally, two hours before the anesthetic procedure (PRE) or after the procedure (POST) and daily for five days. Cats were anesthetized with isoflurane and the concentration was increased until mean arterial pressure reached 40-60mmHg and kept at this level for 60 minutes. During hypotension, the physiological variables were measured at time 0 and every 10 minutes until 60 minutes, and bleeding time was measured at time 0, 30 and 60 minutes. Blood samples were drawn for a hemogram and determination of concentrations of alanine aminotransferase, alkaline phosphatase, urea, creatinine and Na+ at baseline, 24 hours, 48 hours and 7 days post-hypotension. Urine was collected at baseline, 24 hours, 48 hours and 7 days post-hypotension for determination of concentrations of creatinine, gamma-glutamyltransferase, urine specific gravity, protein, albumin and Na+. During the anesthetic procedure there were no important variations in physiological variables and bleeding time. There were differences only in fractional excretion of Na+, which was elevated at 7 days of evaluation in PRE and in the urine protein/creatinine ratio in PRE, which was higher than in POST at 24 and 48 hours post-hypotension. We conclude that tepoxalin does not cause alterations in hepatic enzymes but can cause discrete renal injury, resulting in proteinuria, in cats subjected to 60min of hypotension.Universidade Federal de Santa Maria2014-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782014000600020Ciência Rural v.44 n.6 2014reponame:Ciência Ruralinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM10.1590/S0103-84782014000600020info:eu-repo/semantics/openAccessFreitas,Gabrielle CoelhoCarregaro,Adriano BonfimBisetto,Shayne PedrozoBarbosa,Aline SoaresFantinato Neto,PauloDellova,Deise Carla Almeida LeiteLopes,Carlizeeng2014-09-05T00:00:00ZRevista
dc.title.none.fl_str_mv Tepoxalin on renal function and liver enzymes in cats exposed to hypotension with isoflurane
title Tepoxalin on renal function and liver enzymes in cats exposed to hypotension with isoflurane
spellingShingle Tepoxalin on renal function and liver enzymes in cats exposed to hypotension with isoflurane
Freitas,Gabrielle Coelho
non-steroidal anti-inflammatory drug
nephrotoxicity
hepatotoxicity
title_short Tepoxalin on renal function and liver enzymes in cats exposed to hypotension with isoflurane
title_full Tepoxalin on renal function and liver enzymes in cats exposed to hypotension with isoflurane
title_fullStr Tepoxalin on renal function and liver enzymes in cats exposed to hypotension with isoflurane
title_full_unstemmed Tepoxalin on renal function and liver enzymes in cats exposed to hypotension with isoflurane
title_sort Tepoxalin on renal function and liver enzymes in cats exposed to hypotension with isoflurane
author Freitas,Gabrielle Coelho
author_facet Freitas,Gabrielle Coelho
Carregaro,Adriano Bonfim
Bisetto,Shayne Pedrozo
Barbosa,Aline Soares
Fantinato Neto,Paulo
Dellova,Deise Carla Almeida Leite
Lopes,Carlize
author_role author
author2 Carregaro,Adriano Bonfim
Bisetto,Shayne Pedrozo
Barbosa,Aline Soares
Fantinato Neto,Paulo
Dellova,Deise Carla Almeida Leite
Lopes,Carlize
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Freitas,Gabrielle Coelho
Carregaro,Adriano Bonfim
Bisetto,Shayne Pedrozo
Barbosa,Aline Soares
Fantinato Neto,Paulo
Dellova,Deise Carla Almeida Leite
Lopes,Carlize
dc.subject.por.fl_str_mv non-steroidal anti-inflammatory drug
nephrotoxicity
hepatotoxicity
topic non-steroidal anti-inflammatory drug
nephrotoxicity
hepatotoxicity
description This study aimed to evaluate the possible renal and hepatic toxicity of tepoxalin administered before or after isoflurane-induced hypotension, as well as for five consecutive days. Twelve healthy mixed-breed cats, adult males, weighing 4.0±0.8kg were allocated into two groups. They received 25mgkg-1 of tepoxalin orally, two hours before the anesthetic procedure (PRE) or after the procedure (POST) and daily for five days. Cats were anesthetized with isoflurane and the concentration was increased until mean arterial pressure reached 40-60mmHg and kept at this level for 60 minutes. During hypotension, the physiological variables were measured at time 0 and every 10 minutes until 60 minutes, and bleeding time was measured at time 0, 30 and 60 minutes. Blood samples were drawn for a hemogram and determination of concentrations of alanine aminotransferase, alkaline phosphatase, urea, creatinine and Na+ at baseline, 24 hours, 48 hours and 7 days post-hypotension. Urine was collected at baseline, 24 hours, 48 hours and 7 days post-hypotension for determination of concentrations of creatinine, gamma-glutamyltransferase, urine specific gravity, protein, albumin and Na+. During the anesthetic procedure there were no important variations in physiological variables and bleeding time. There were differences only in fractional excretion of Na+, which was elevated at 7 days of evaluation in PRE and in the urine protein/creatinine ratio in PRE, which was higher than in POST at 24 and 48 hours post-hypotension. We conclude that tepoxalin does not cause alterations in hepatic enzymes but can cause discrete renal injury, resulting in proteinuria, in cats subjected to 60min of hypotension.
publishDate 2014
dc.date.none.fl_str_mv 2014-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782014000600020
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782014000600020
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-84782014000600020
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Universidade Federal de Santa Maria
publisher.none.fl_str_mv Universidade Federal de Santa Maria
dc.source.none.fl_str_mv Ciência Rural v.44 n.6 2014
reponame:Ciência Rural
instname:Universidade Federal de Santa Maria (UFSM)
instacron:UFSM
instname_str Universidade Federal de Santa Maria (UFSM)
instacron_str UFSM
institution UFSM
reponame_str Ciência Rural
collection Ciência Rural
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repository.mail.fl_str_mv
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