Detection of Lsr2 gene of Mycobacterium leprae in nasal mucus

Detalhes bibliográficos
Autor(a) principal: Custodio,Luiz Antonio
Data de Publicação: 2012
Outros Autores: Saito,Alexandre, Amarante,Marla Karine, Fujita,Thiago Cezar, Perim,Aparecida de Lourdes, Costa,Ivete Conchon, Felipe,Ionice, Jankevicius,Shiduca Itow
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Archives of Biology and Technology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000300007
Resumo: In the present study, nasal mucus from patients with leprosy were analyzed by PCR using specific primers for Lsr2 gene of Mycobacterium leprae. The presence of Lsr2 gene in the nasal mucus was detected in 25.80% of patients with paucibacillari leprosy, and 23.07% of contacts. Despite the absence of clinical features in the contact individuals, it was possible to detect the presence of Lsr2 gene in the nasal mucus of these individuals. Therefore, PCR detection of M. leprae targeting Lsr2 gene using nasal mucus samples could contribute to early diagnosis of leprosy.
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spelling Detection of Lsr2 gene of Mycobacterium leprae in nasal mucusMycobacterium lepraeleprosyhanseniasenasal mucusPCRIn the present study, nasal mucus from patients with leprosy were analyzed by PCR using specific primers for Lsr2 gene of Mycobacterium leprae. The presence of Lsr2 gene in the nasal mucus was detected in 25.80% of patients with paucibacillari leprosy, and 23.07% of contacts. Despite the absence of clinical features in the contact individuals, it was possible to detect the presence of Lsr2 gene in the nasal mucus of these individuals. Therefore, PCR detection of M. leprae targeting Lsr2 gene using nasal mucus samples could contribute to early diagnosis of leprosy.Instituto de Tecnologia do Paraná - Tecpar2012-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000300007Brazilian Archives of Biology and Technology v.55 n.3 2012reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-89132012000300007info:eu-repo/semantics/openAccessCustodio,Luiz AntonioSaito,AlexandreAmarante,Marla KarineFujita,Thiago CezarPerim,Aparecida de LourdesCosta,Ivete ConchonFelipe,IoniceJankevicius,Shiduca Itoweng2012-07-03T00:00:00Zoai:scielo:S1516-89132012000300007Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2012-07-03T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false
dc.title.none.fl_str_mv Detection of Lsr2 gene of Mycobacterium leprae in nasal mucus
title Detection of Lsr2 gene of Mycobacterium leprae in nasal mucus
spellingShingle Detection of Lsr2 gene of Mycobacterium leprae in nasal mucus
Custodio,Luiz Antonio
Mycobacterium leprae
leprosy
hanseniase
nasal mucus
PCR
title_short Detection of Lsr2 gene of Mycobacterium leprae in nasal mucus
title_full Detection of Lsr2 gene of Mycobacterium leprae in nasal mucus
title_fullStr Detection of Lsr2 gene of Mycobacterium leprae in nasal mucus
title_full_unstemmed Detection of Lsr2 gene of Mycobacterium leprae in nasal mucus
title_sort Detection of Lsr2 gene of Mycobacterium leprae in nasal mucus
author Custodio,Luiz Antonio
author_facet Custodio,Luiz Antonio
Saito,Alexandre
Amarante,Marla Karine
Fujita,Thiago Cezar
Perim,Aparecida de Lourdes
Costa,Ivete Conchon
Felipe,Ionice
Jankevicius,Shiduca Itow
author_role author
author2 Saito,Alexandre
Amarante,Marla Karine
Fujita,Thiago Cezar
Perim,Aparecida de Lourdes
Costa,Ivete Conchon
Felipe,Ionice
Jankevicius,Shiduca Itow
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Custodio,Luiz Antonio
Saito,Alexandre
Amarante,Marla Karine
Fujita,Thiago Cezar
Perim,Aparecida de Lourdes
Costa,Ivete Conchon
Felipe,Ionice
Jankevicius,Shiduca Itow
dc.subject.por.fl_str_mv Mycobacterium leprae
leprosy
hanseniase
nasal mucus
PCR
topic Mycobacterium leprae
leprosy
hanseniase
nasal mucus
PCR
description In the present study, nasal mucus from patients with leprosy were analyzed by PCR using specific primers for Lsr2 gene of Mycobacterium leprae. The presence of Lsr2 gene in the nasal mucus was detected in 25.80% of patients with paucibacillari leprosy, and 23.07% of contacts. Despite the absence of clinical features in the contact individuals, it was possible to detect the presence of Lsr2 gene in the nasal mucus of these individuals. Therefore, PCR detection of M. leprae targeting Lsr2 gene using nasal mucus samples could contribute to early diagnosis of leprosy.
publishDate 2012
dc.date.none.fl_str_mv 2012-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000300007
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000300007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-89132012000300007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
dc.source.none.fl_str_mv Brazilian Archives of Biology and Technology v.55 n.3 2012
reponame:Brazilian Archives of Biology and Technology
instname:Instituto de Tecnologia do Paraná (Tecpar)
instacron:TECPAR
instname_str Instituto de Tecnologia do Paraná (Tecpar)
instacron_str TECPAR
institution TECPAR
reponame_str Brazilian Archives of Biology and Technology
collection Brazilian Archives of Biology and Technology
repository.name.fl_str_mv Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)
repository.mail.fl_str_mv babt@tecpar.br||babt@tecpar.br
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