Influence of Lycium barbarum Extract Intake on Oxidative Stress in Wistar Rats

• Autor(a) principal: Janke,Fernanda
• Data de Publicação: 2022
• Outros Autores: Trindade,Fernanda Moura Ribeiro, Penteado,Júlia Oliveira, Nogueira,Camila Castencio, Uecker,Júlia Neitzel, Schneider,Janaína Pereira, Nickel Ávila,Caroline, Rincón,Joao Alveiro Alvarado, Barros,Carlos Castilho de, Jaskulski,Itiane Barcellos, Andreazza,Robson, Oliveira,Jordan Teixeira, Pieniz,Simone
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Brazilian Archives of Biology and Technology
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132022000100405
• topic: Goji Berry; Oxidative damage; Lipid peroxidation; Antioxidant enzymes

Abstract: This study aimed to analyze the effects of Goji Berry extract (GB, Lycium barbarum) gavage administration on liver tissue oxidative stress in Wistar rats as well as to identify and quantify the content of the major bioactive compounds of the fruit. Four diets were applied: SW - standard diet + water; SG - standard diet + Goji Berry extract (125 mg/kg of animal); PW - palatable diet + water; PG - palatable diet + Goji Berry extract (125 mg/kg of animal). Results showed a significant increase in catalase enzyme activity in the liver of rats treated with GB and also in those intaking the palatable diet without GB when compared to the SW group. An increased mRNA expression of this enzyme in the same tissue and groups was also verified. Regarding lipid peroxidation, the GB extract produced a significant decrease in the oxidation state in the SG and PG groups. The results also showed a significant amount of bioactive compounds in GB extract.