Alkaline phosphatase activity in plasma and liver of rats submitted to chronic exposure to fluoride
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Archives of Biology and Technology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000600014 |
Resumo: | The aim of this study was to compare the effect of fluoride (F) on alkaline phosphatase activity in the liver and plasma of the rats. Four groups of male Wistar rats (n=6), which received drinking water containing 5, 15 or 50 ppm F or deionized water (control) throughout the experiment were included in the study. The animals were euthanized and had their tissues and blood plasma collected for the analysis of fluoride and alkaline phosphatase. There was an increase in F concentration in most tissues in the animals treated with higher F concentrations, except for the heart. The alkaline phosphatase assay showed an increase in the activity in the liver and blood plasma of the animals treated with fluoride concentrations of 15 and 50 ppm (p<0.05). This study suggested that F at a concentration of 50 ppm in drinking water promotes increased the activity of alkaline phosphatase in the liver and blood plasma. |
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Brazilian Archives of Biology and Technology |
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Alkaline phosphatase activity in plasma and liver of rats submitted to chronic exposure to fluoridealkaline phosphatasefluorideliverkidneyThe aim of this study was to compare the effect of fluoride (F) on alkaline phosphatase activity in the liver and plasma of the rats. Four groups of male Wistar rats (n=6), which received drinking water containing 5, 15 or 50 ppm F or deionized water (control) throughout the experiment were included in the study. The animals were euthanized and had their tissues and blood plasma collected for the analysis of fluoride and alkaline phosphatase. There was an increase in F concentration in most tissues in the animals treated with higher F concentrations, except for the heart. The alkaline phosphatase assay showed an increase in the activity in the liver and blood plasma of the animals treated with fluoride concentrations of 15 and 50 ppm (p<0.05). This study suggested that F at a concentration of 50 ppm in drinking water promotes increased the activity of alkaline phosphatase in the liver and blood plasma.Instituto de Tecnologia do Paraná - Tecpar2011-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000600014Brazilian Archives of Biology and Technology v.54 n.6 2011reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-89132011000600014info:eu-repo/semantics/openAccessFernandes,Mileni da SilvaIano,Flávia GodoyRocia,VivianYanai,Marcela MitsukoLeite,Aline de LimaFurlani,Tatiana AlmeidaBuzalaf,Marília Afonso RabeloOliveira,Rodrigo Cardoso deeng2011-12-13T00:00:00Zoai:scielo:S1516-89132011000600014Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2011-12-13T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false |
dc.title.none.fl_str_mv |
Alkaline phosphatase activity in plasma and liver of rats submitted to chronic exposure to fluoride |
title |
Alkaline phosphatase activity in plasma and liver of rats submitted to chronic exposure to fluoride |
spellingShingle |
Alkaline phosphatase activity in plasma and liver of rats submitted to chronic exposure to fluoride Fernandes,Mileni da Silva alkaline phosphatase fluoride liver kidney |
title_short |
Alkaline phosphatase activity in plasma and liver of rats submitted to chronic exposure to fluoride |
title_full |
Alkaline phosphatase activity in plasma and liver of rats submitted to chronic exposure to fluoride |
title_fullStr |
Alkaline phosphatase activity in plasma and liver of rats submitted to chronic exposure to fluoride |
title_full_unstemmed |
Alkaline phosphatase activity in plasma and liver of rats submitted to chronic exposure to fluoride |
title_sort |
Alkaline phosphatase activity in plasma and liver of rats submitted to chronic exposure to fluoride |
author |
Fernandes,Mileni da Silva |
author_facet |
Fernandes,Mileni da Silva Iano,Flávia Godoy Rocia,Vivian Yanai,Marcela Mitsuko Leite,Aline de Lima Furlani,Tatiana Almeida Buzalaf,Marília Afonso Rabelo Oliveira,Rodrigo Cardoso de |
author_role |
author |
author2 |
Iano,Flávia Godoy Rocia,Vivian Yanai,Marcela Mitsuko Leite,Aline de Lima Furlani,Tatiana Almeida Buzalaf,Marília Afonso Rabelo Oliveira,Rodrigo Cardoso de |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Fernandes,Mileni da Silva Iano,Flávia Godoy Rocia,Vivian Yanai,Marcela Mitsuko Leite,Aline de Lima Furlani,Tatiana Almeida Buzalaf,Marília Afonso Rabelo Oliveira,Rodrigo Cardoso de |
dc.subject.por.fl_str_mv |
alkaline phosphatase fluoride liver kidney |
topic |
alkaline phosphatase fluoride liver kidney |
description |
The aim of this study was to compare the effect of fluoride (F) on alkaline phosphatase activity in the liver and plasma of the rats. Four groups of male Wistar rats (n=6), which received drinking water containing 5, 15 or 50 ppm F or deionized water (control) throughout the experiment were included in the study. The animals were euthanized and had their tissues and blood plasma collected for the analysis of fluoride and alkaline phosphatase. There was an increase in F concentration in most tissues in the animals treated with higher F concentrations, except for the heart. The alkaline phosphatase assay showed an increase in the activity in the liver and blood plasma of the animals treated with fluoride concentrations of 15 and 50 ppm (p<0.05). This study suggested that F at a concentration of 50 ppm in drinking water promotes increased the activity of alkaline phosphatase in the liver and blood plasma. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000600014 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000600014 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1516-89132011000600014 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
dc.source.none.fl_str_mv |
Brazilian Archives of Biology and Technology v.54 n.6 2011 reponame:Brazilian Archives of Biology and Technology instname:Instituto de Tecnologia do Paraná (Tecpar) instacron:TECPAR |
instname_str |
Instituto de Tecnologia do Paraná (Tecpar) |
instacron_str |
TECPAR |
institution |
TECPAR |
reponame_str |
Brazilian Archives of Biology and Technology |
collection |
Brazilian Archives of Biology and Technology |
repository.name.fl_str_mv |
Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar) |
repository.mail.fl_str_mv |
babt@tecpar.br||babt@tecpar.br |
_version_ |
1750318274869985280 |