The genoprotective activity of resveratrol on permethrin-induced genotoxic damage in cultured human lymphocytes
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Archives of Biology and Technology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000300008 |
Resumo: | The aim of this work was to investigate the genetic effects of resveratrol (RSV) at concentrations of 10, 15, 25, 40, 75 and 100 µM and its activities on the genotoxicity induced by the permethrin (PM) (200 µM). After the application of PM and RSV, separately and together, cultured human lymphocytes were assessed by chromosome aberrations (CA) and sister chromatid exchange (SCE) tests. According to results, the frequencies of CA and SCE rates in the peripheral lymphocytes were significantly increased by PM compared with the controls. However, RSV had no genotoxic effect. Furthermore, the findings revealed that PM-induced increases in the mean frequencies of both genotoxic indices were diminished by RSV in a clear dose dependent manner, indicating its protective role towards the cells from PM exerted injury. In conclusion, these effects of RSV should be considered while evaluating the possible use of RSV as a therapeutic agent. |
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The genoprotective activity of resveratrol on permethrin-induced genotoxic damage in cultured human lymphocytesChromosome aberrationmutagenicitypermethrinresveratrolsister chromatid exchangeThe aim of this work was to investigate the genetic effects of resveratrol (RSV) at concentrations of 10, 15, 25, 40, 75 and 100 µM and its activities on the genotoxicity induced by the permethrin (PM) (200 µM). After the application of PM and RSV, separately and together, cultured human lymphocytes were assessed by chromosome aberrations (CA) and sister chromatid exchange (SCE) tests. According to results, the frequencies of CA and SCE rates in the peripheral lymphocytes were significantly increased by PM compared with the controls. However, RSV had no genotoxic effect. Furthermore, the findings revealed that PM-induced increases in the mean frequencies of both genotoxic indices were diminished by RSV in a clear dose dependent manner, indicating its protective role towards the cells from PM exerted injury. In conclusion, these effects of RSV should be considered while evaluating the possible use of RSV as a therapeutic agent.Instituto de Tecnologia do Paraná - Tecpar2013-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000300008Brazilian Archives of Biology and Technology v.56 n.3 2013reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-89132013000300008info:eu-repo/semantics/openAccessTurkez,HasanAydin,Elanureng2013-07-12T00:00:00Zoai:scielo:S1516-89132013000300008Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2013-07-12T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false |
dc.title.none.fl_str_mv |
The genoprotective activity of resveratrol on permethrin-induced genotoxic damage in cultured human lymphocytes |
title |
The genoprotective activity of resveratrol on permethrin-induced genotoxic damage in cultured human lymphocytes |
spellingShingle |
The genoprotective activity of resveratrol on permethrin-induced genotoxic damage in cultured human lymphocytes Turkez,Hasan Chromosome aberration mutagenicity permethrin resveratrol sister chromatid exchange |
title_short |
The genoprotective activity of resveratrol on permethrin-induced genotoxic damage in cultured human lymphocytes |
title_full |
The genoprotective activity of resveratrol on permethrin-induced genotoxic damage in cultured human lymphocytes |
title_fullStr |
The genoprotective activity of resveratrol on permethrin-induced genotoxic damage in cultured human lymphocytes |
title_full_unstemmed |
The genoprotective activity of resveratrol on permethrin-induced genotoxic damage in cultured human lymphocytes |
title_sort |
The genoprotective activity of resveratrol on permethrin-induced genotoxic damage in cultured human lymphocytes |
author |
Turkez,Hasan |
author_facet |
Turkez,Hasan Aydin,Elanur |
author_role |
author |
author2 |
Aydin,Elanur |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Turkez,Hasan Aydin,Elanur |
dc.subject.por.fl_str_mv |
Chromosome aberration mutagenicity permethrin resveratrol sister chromatid exchange |
topic |
Chromosome aberration mutagenicity permethrin resveratrol sister chromatid exchange |
description |
The aim of this work was to investigate the genetic effects of resveratrol (RSV) at concentrations of 10, 15, 25, 40, 75 and 100 µM and its activities on the genotoxicity induced by the permethrin (PM) (200 µM). After the application of PM and RSV, separately and together, cultured human lymphocytes were assessed by chromosome aberrations (CA) and sister chromatid exchange (SCE) tests. According to results, the frequencies of CA and SCE rates in the peripheral lymphocytes were significantly increased by PM compared with the controls. However, RSV had no genotoxic effect. Furthermore, the findings revealed that PM-induced increases in the mean frequencies of both genotoxic indices were diminished by RSV in a clear dose dependent manner, indicating its protective role towards the cells from PM exerted injury. In conclusion, these effects of RSV should be considered while evaluating the possible use of RSV as a therapeutic agent. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000300008 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000300008 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1516-89132013000300008 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
dc.source.none.fl_str_mv |
Brazilian Archives of Biology and Technology v.56 n.3 2013 reponame:Brazilian Archives of Biology and Technology instname:Instituto de Tecnologia do Paraná (Tecpar) instacron:TECPAR |
instname_str |
Instituto de Tecnologia do Paraná (Tecpar) |
instacron_str |
TECPAR |
institution |
TECPAR |
reponame_str |
Brazilian Archives of Biology and Technology |
collection |
Brazilian Archives of Biology and Technology |
repository.name.fl_str_mv |
Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar) |
repository.mail.fl_str_mv |
babt@tecpar.br||babt@tecpar.br |
_version_ |
1750318275651174400 |