The genoprotective activity of resveratrol on permethrin-induced genotoxic damage in cultured human lymphocytes

Detalhes bibliográficos
Autor(a) principal: Turkez,Hasan
Data de Publicação: 2013
Outros Autores: Aydin,Elanur
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Archives of Biology and Technology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000300008
Resumo: The aim of this work was to investigate the genetic effects of resveratrol (RSV) at concentrations of 10, 15, 25, 40, 75 and 100 µM and its activities on the genotoxicity induced by the permethrin (PM) (200 µM). After the application of PM and RSV, separately and together, cultured human lymphocytes were assessed by chromosome aberrations (CA) and sister chromatid exchange (SCE) tests. According to results, the frequencies of CA and SCE rates in the peripheral lymphocytes were significantly increased by PM compared with the controls. However, RSV had no genotoxic effect. Furthermore, the findings revealed that PM-induced increases in the mean frequencies of both genotoxic indices were diminished by RSV in a clear dose dependent manner, indicating its protective role towards the cells from PM exerted injury. In conclusion, these effects of RSV should be considered while evaluating the possible use of RSV as a therapeutic agent.
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spelling The genoprotective activity of resveratrol on permethrin-induced genotoxic damage in cultured human lymphocytesChromosome aberrationmutagenicitypermethrinresveratrolsister chromatid exchangeThe aim of this work was to investigate the genetic effects of resveratrol (RSV) at concentrations of 10, 15, 25, 40, 75 and 100 µM and its activities on the genotoxicity induced by the permethrin (PM) (200 µM). After the application of PM and RSV, separately and together, cultured human lymphocytes were assessed by chromosome aberrations (CA) and sister chromatid exchange (SCE) tests. According to results, the frequencies of CA and SCE rates in the peripheral lymphocytes were significantly increased by PM compared with the controls. However, RSV had no genotoxic effect. Furthermore, the findings revealed that PM-induced increases in the mean frequencies of both genotoxic indices were diminished by RSV in a clear dose dependent manner, indicating its protective role towards the cells from PM exerted injury. In conclusion, these effects of RSV should be considered while evaluating the possible use of RSV as a therapeutic agent.Instituto de Tecnologia do Paraná - Tecpar2013-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000300008Brazilian Archives of Biology and Technology v.56 n.3 2013reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-89132013000300008info:eu-repo/semantics/openAccessTurkez,HasanAydin,Elanureng2013-07-12T00:00:00Zoai:scielo:S1516-89132013000300008Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2013-07-12T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false
dc.title.none.fl_str_mv The genoprotective activity of resveratrol on permethrin-induced genotoxic damage in cultured human lymphocytes
title The genoprotective activity of resveratrol on permethrin-induced genotoxic damage in cultured human lymphocytes
spellingShingle The genoprotective activity of resveratrol on permethrin-induced genotoxic damage in cultured human lymphocytes
Turkez,Hasan
Chromosome aberration
mutagenicity
permethrin
resveratrol
sister chromatid exchange
title_short The genoprotective activity of resveratrol on permethrin-induced genotoxic damage in cultured human lymphocytes
title_full The genoprotective activity of resveratrol on permethrin-induced genotoxic damage in cultured human lymphocytes
title_fullStr The genoprotective activity of resveratrol on permethrin-induced genotoxic damage in cultured human lymphocytes
title_full_unstemmed The genoprotective activity of resveratrol on permethrin-induced genotoxic damage in cultured human lymphocytes
title_sort The genoprotective activity of resveratrol on permethrin-induced genotoxic damage in cultured human lymphocytes
author Turkez,Hasan
author_facet Turkez,Hasan
Aydin,Elanur
author_role author
author2 Aydin,Elanur
author2_role author
dc.contributor.author.fl_str_mv Turkez,Hasan
Aydin,Elanur
dc.subject.por.fl_str_mv Chromosome aberration
mutagenicity
permethrin
resveratrol
sister chromatid exchange
topic Chromosome aberration
mutagenicity
permethrin
resveratrol
sister chromatid exchange
description The aim of this work was to investigate the genetic effects of resveratrol (RSV) at concentrations of 10, 15, 25, 40, 75 and 100 µM and its activities on the genotoxicity induced by the permethrin (PM) (200 µM). After the application of PM and RSV, separately and together, cultured human lymphocytes were assessed by chromosome aberrations (CA) and sister chromatid exchange (SCE) tests. According to results, the frequencies of CA and SCE rates in the peripheral lymphocytes were significantly increased by PM compared with the controls. However, RSV had no genotoxic effect. Furthermore, the findings revealed that PM-induced increases in the mean frequencies of both genotoxic indices were diminished by RSV in a clear dose dependent manner, indicating its protective role towards the cells from PM exerted injury. In conclusion, these effects of RSV should be considered while evaluating the possible use of RSV as a therapeutic agent.
publishDate 2013
dc.date.none.fl_str_mv 2013-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000300008
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000300008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-89132013000300008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
dc.source.none.fl_str_mv Brazilian Archives of Biology and Technology v.56 n.3 2013
reponame:Brazilian Archives of Biology and Technology
instname:Instituto de Tecnologia do Paraná (Tecpar)
instacron:TECPAR
instname_str Instituto de Tecnologia do Paraná (Tecpar)
instacron_str TECPAR
institution TECPAR
reponame_str Brazilian Archives of Biology and Technology
collection Brazilian Archives of Biology and Technology
repository.name.fl_str_mv Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)
repository.mail.fl_str_mv babt@tecpar.br||babt@tecpar.br
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