Acetylsalicylic acid and morphology of red blood cells

• Autor(a) principal: Frydman,Jacques Natan Grinapel
• Data de Publicação: 2010
• Outros Autores: Fonseca,Adenilson de Souza da, Rocha,Vanessa Câmara da, Benarroz,Monica Oliveira, Rocha,Gabrielle de Souza, Pereira,Marcia de Oliveira, Pereira,Mario José, Medeiros,Aldo Cunha, Bernardo-Filho,Mario
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Brazilian Archives of Biology and Technology
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000300010
• topic: Acetylsalicylic Acid; Blood Cells; Morphology

This work evaluated the effect of in vitro and in vivo treatment with ASA on the morphology of the red blood cells. Blood samples or Wistar rats were treated with ASA for one hour. Blood samples or animals treated with saline were used as control group. Blood smears were prepared, fixed, stained and the qualitative and quantitative morphology of red blood cells were evaluated under optical microscopy. Data showed that the in vitro treatment for one hour with ASA at higher dose used significantly (p<0.05) modified the perimeter/area ratio of the red blood cells. No morphological alterations were obtained with the in vivo treatment. ASA use at highest doses could interfere on shape of red blood cells.