Neonatally induced diabetes: liver glycogen storage in pregnant rats
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Archives of Biology and Technology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000200010 |
Resumo: | The aim of this sstudy was to evaluate the liver glycogen storage in pregnant rats presenting neonatal streptozotocin-induced diabetes and to establish a relation with glycemia and insulin levels. Wistar rats were divided in to two groups: 1) Mild Diabetes (STZ) - received streptozotocin (glycemia from 120 to 300 mg/dL), 2) Control - received vehicle (glycemia below 120 mg/dL). At days 0, 7, 14 and 21 of the pregnancy, body weight and glycemia were evaluated. At day 21 of the pregnancy, the rats were anesthetized for blood and liver collection so as to determine insulin and liver glycogen, which showed no changes in the STZ group as compared to the controls. In the STZ group, maternal weight gain were lower as compared to those in the control group. Significantly increased glycemia was observed at days 0 and 14 of the pregnancy in the STZ group. Therefore, neonatally induced diabetes in the rats did not cause metabolic changes that impaired insulin and liver glycogen relation in these rats. |
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Brazilian Archives of Biology and Technology |
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Neonatally induced diabetes: liver glycogen storage in pregnant ratspregnancyrathyperglycemiaglycogen storage livermild diabeteshyperglycemiaThe aim of this sstudy was to evaluate the liver glycogen storage in pregnant rats presenting neonatal streptozotocin-induced diabetes and to establish a relation with glycemia and insulin levels. Wistar rats were divided in to two groups: 1) Mild Diabetes (STZ) - received streptozotocin (glycemia from 120 to 300 mg/dL), 2) Control - received vehicle (glycemia below 120 mg/dL). At days 0, 7, 14 and 21 of the pregnancy, body weight and glycemia were evaluated. At day 21 of the pregnancy, the rats were anesthetized for blood and liver collection so as to determine insulin and liver glycogen, which showed no changes in the STZ group as compared to the controls. In the STZ group, maternal weight gain were lower as compared to those in the control group. Significantly increased glycemia was observed at days 0 and 14 of the pregnancy in the STZ group. Therefore, neonatally induced diabetes in the rats did not cause metabolic changes that impaired insulin and liver glycogen relation in these rats.Instituto de Tecnologia do Paraná - Tecpar2012-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000200010Brazilian Archives of Biology and Technology v.55 n.2 2012reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-89132012000200010info:eu-repo/semantics/openAccessIessi,Isabela LovizuttoBueno,AlineSinzato,Yuri KarenSpada,Ana Paula MachadoRudge,Marilza Vieira CunhaHeubel,Maricê Thereza Correa DominguesDamasceno,Débora Cristinaeng2012-05-03T00:00:00Zoai:scielo:S1516-89132012000200010Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2012-05-03T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false |
dc.title.none.fl_str_mv |
Neonatally induced diabetes: liver glycogen storage in pregnant rats |
title |
Neonatally induced diabetes: liver glycogen storage in pregnant rats |
spellingShingle |
Neonatally induced diabetes: liver glycogen storage in pregnant rats Iessi,Isabela Lovizutto pregnancy rat hyperglycemia glycogen storage liver mild diabetes hyperglycemia |
title_short |
Neonatally induced diabetes: liver glycogen storage in pregnant rats |
title_full |
Neonatally induced diabetes: liver glycogen storage in pregnant rats |
title_fullStr |
Neonatally induced diabetes: liver glycogen storage in pregnant rats |
title_full_unstemmed |
Neonatally induced diabetes: liver glycogen storage in pregnant rats |
title_sort |
Neonatally induced diabetes: liver glycogen storage in pregnant rats |
author |
Iessi,Isabela Lovizutto |
author_facet |
Iessi,Isabela Lovizutto Bueno,Aline Sinzato,Yuri Karen Spada,Ana Paula Machado Rudge,Marilza Vieira Cunha Heubel,Maricê Thereza Correa Domingues Damasceno,Débora Cristina |
author_role |
author |
author2 |
Bueno,Aline Sinzato,Yuri Karen Spada,Ana Paula Machado Rudge,Marilza Vieira Cunha Heubel,Maricê Thereza Correa Domingues Damasceno,Débora Cristina |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Iessi,Isabela Lovizutto Bueno,Aline Sinzato,Yuri Karen Spada,Ana Paula Machado Rudge,Marilza Vieira Cunha Heubel,Maricê Thereza Correa Domingues Damasceno,Débora Cristina |
dc.subject.por.fl_str_mv |
pregnancy rat hyperglycemia glycogen storage liver mild diabetes hyperglycemia |
topic |
pregnancy rat hyperglycemia glycogen storage liver mild diabetes hyperglycemia |
description |
The aim of this sstudy was to evaluate the liver glycogen storage in pregnant rats presenting neonatal streptozotocin-induced diabetes and to establish a relation with glycemia and insulin levels. Wistar rats were divided in to two groups: 1) Mild Diabetes (STZ) - received streptozotocin (glycemia from 120 to 300 mg/dL), 2) Control - received vehicle (glycemia below 120 mg/dL). At days 0, 7, 14 and 21 of the pregnancy, body weight and glycemia were evaluated. At day 21 of the pregnancy, the rats were anesthetized for blood and liver collection so as to determine insulin and liver glycogen, which showed no changes in the STZ group as compared to the controls. In the STZ group, maternal weight gain were lower as compared to those in the control group. Significantly increased glycemia was observed at days 0 and 14 of the pregnancy in the STZ group. Therefore, neonatally induced diabetes in the rats did not cause metabolic changes that impaired insulin and liver glycogen relation in these rats. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000200010 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000200010 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1516-89132012000200010 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
dc.source.none.fl_str_mv |
Brazilian Archives of Biology and Technology v.55 n.2 2012 reponame:Brazilian Archives of Biology and Technology instname:Instituto de Tecnologia do Paraná (Tecpar) instacron:TECPAR |
instname_str |
Instituto de Tecnologia do Paraná (Tecpar) |
instacron_str |
TECPAR |
institution |
TECPAR |
reponame_str |
Brazilian Archives of Biology and Technology |
collection |
Brazilian Archives of Biology and Technology |
repository.name.fl_str_mv |
Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar) |
repository.mail.fl_str_mv |
babt@tecpar.br||babt@tecpar.br |
_version_ |
1750318275184558080 |