Neonatally induced diabetes: liver glycogen storage in pregnant rats

Detalhes bibliográficos
Autor(a) principal: Iessi,Isabela Lovizutto
Data de Publicação: 2012
Outros Autores: Bueno,Aline, Sinzato,Yuri Karen, Spada,Ana Paula Machado, Rudge,Marilza Vieira Cunha, Heubel,Maricê Thereza Correa Domingues, Damasceno,Débora Cristina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Archives of Biology and Technology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000200010
Resumo: The aim of this sstudy was to evaluate the liver glycogen storage in pregnant rats presenting neonatal streptozotocin-induced diabetes and to establish a relation with glycemia and insulin levels. Wistar rats were divided in to two groups: 1) Mild Diabetes (STZ) - received streptozotocin (glycemia from 120 to 300 mg/dL), 2) Control - received vehicle (glycemia below 120 mg/dL). At days 0, 7, 14 and 21 of the pregnancy, body weight and glycemia were evaluated. At day 21 of the pregnancy, the rats were anesthetized for blood and liver collection so as to determine insulin and liver glycogen, which showed no changes in the STZ group as compared to the controls. In the STZ group, maternal weight gain were lower as compared to those in the control group. Significantly increased glycemia was observed at days 0 and 14 of the pregnancy in the STZ group. Therefore, neonatally induced diabetes in the rats did not cause metabolic changes that impaired insulin and liver glycogen relation in these rats.
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spelling Neonatally induced diabetes: liver glycogen storage in pregnant ratspregnancyrathyperglycemiaglycogen storage livermild diabeteshyperglycemiaThe aim of this sstudy was to evaluate the liver glycogen storage in pregnant rats presenting neonatal streptozotocin-induced diabetes and to establish a relation with glycemia and insulin levels. Wistar rats were divided in to two groups: 1) Mild Diabetes (STZ) - received streptozotocin (glycemia from 120 to 300 mg/dL), 2) Control - received vehicle (glycemia below 120 mg/dL). At days 0, 7, 14 and 21 of the pregnancy, body weight and glycemia were evaluated. At day 21 of the pregnancy, the rats were anesthetized for blood and liver collection so as to determine insulin and liver glycogen, which showed no changes in the STZ group as compared to the controls. In the STZ group, maternal weight gain were lower as compared to those in the control group. Significantly increased glycemia was observed at days 0 and 14 of the pregnancy in the STZ group. Therefore, neonatally induced diabetes in the rats did not cause metabolic changes that impaired insulin and liver glycogen relation in these rats.Instituto de Tecnologia do Paraná - Tecpar2012-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000200010Brazilian Archives of Biology and Technology v.55 n.2 2012reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-89132012000200010info:eu-repo/semantics/openAccessIessi,Isabela LovizuttoBueno,AlineSinzato,Yuri KarenSpada,Ana Paula MachadoRudge,Marilza Vieira CunhaHeubel,Maricê Thereza Correa DominguesDamasceno,Débora Cristinaeng2012-05-03T00:00:00Zoai:scielo:S1516-89132012000200010Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2012-05-03T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false
dc.title.none.fl_str_mv Neonatally induced diabetes: liver glycogen storage in pregnant rats
title Neonatally induced diabetes: liver glycogen storage in pregnant rats
spellingShingle Neonatally induced diabetes: liver glycogen storage in pregnant rats
Iessi,Isabela Lovizutto
pregnancy
rat
hyperglycemia
glycogen storage liver
mild diabetes
hyperglycemia
title_short Neonatally induced diabetes: liver glycogen storage in pregnant rats
title_full Neonatally induced diabetes: liver glycogen storage in pregnant rats
title_fullStr Neonatally induced diabetes: liver glycogen storage in pregnant rats
title_full_unstemmed Neonatally induced diabetes: liver glycogen storage in pregnant rats
title_sort Neonatally induced diabetes: liver glycogen storage in pregnant rats
author Iessi,Isabela Lovizutto
author_facet Iessi,Isabela Lovizutto
Bueno,Aline
Sinzato,Yuri Karen
Spada,Ana Paula Machado
Rudge,Marilza Vieira Cunha
Heubel,Maricê Thereza Correa Domingues
Damasceno,Débora Cristina
author_role author
author2 Bueno,Aline
Sinzato,Yuri Karen
Spada,Ana Paula Machado
Rudge,Marilza Vieira Cunha
Heubel,Maricê Thereza Correa Domingues
Damasceno,Débora Cristina
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Iessi,Isabela Lovizutto
Bueno,Aline
Sinzato,Yuri Karen
Spada,Ana Paula Machado
Rudge,Marilza Vieira Cunha
Heubel,Maricê Thereza Correa Domingues
Damasceno,Débora Cristina
dc.subject.por.fl_str_mv pregnancy
rat
hyperglycemia
glycogen storage liver
mild diabetes
hyperglycemia
topic pregnancy
rat
hyperglycemia
glycogen storage liver
mild diabetes
hyperglycemia
description The aim of this sstudy was to evaluate the liver glycogen storage in pregnant rats presenting neonatal streptozotocin-induced diabetes and to establish a relation with glycemia and insulin levels. Wistar rats were divided in to two groups: 1) Mild Diabetes (STZ) - received streptozotocin (glycemia from 120 to 300 mg/dL), 2) Control - received vehicle (glycemia below 120 mg/dL). At days 0, 7, 14 and 21 of the pregnancy, body weight and glycemia were evaluated. At day 21 of the pregnancy, the rats were anesthetized for blood and liver collection so as to determine insulin and liver glycogen, which showed no changes in the STZ group as compared to the controls. In the STZ group, maternal weight gain were lower as compared to those in the control group. Significantly increased glycemia was observed at days 0 and 14 of the pregnancy in the STZ group. Therefore, neonatally induced diabetes in the rats did not cause metabolic changes that impaired insulin and liver glycogen relation in these rats.
publishDate 2012
dc.date.none.fl_str_mv 2012-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000200010
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000200010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-89132012000200010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
dc.source.none.fl_str_mv Brazilian Archives of Biology and Technology v.55 n.2 2012
reponame:Brazilian Archives of Biology and Technology
instname:Instituto de Tecnologia do Paraná (Tecpar)
instacron:TECPAR
instname_str Instituto de Tecnologia do Paraná (Tecpar)
instacron_str TECPAR
institution TECPAR
reponame_str Brazilian Archives of Biology and Technology
collection Brazilian Archives of Biology and Technology
repository.name.fl_str_mv Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)
repository.mail.fl_str_mv babt@tecpar.br||babt@tecpar.br
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