Neonatally induced diabetes: liver glycogen storage in pregnant rats
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S1516-89132012000200010 http://hdl.handle.net/11449/12088 |
Resumo: | The aim of this sstudy was to evaluate the liver glycogen storage in pregnant rats presenting neonatal streptozotocin-induced diabetes and to establish a relation with glycemia and insulin levels. Wistar rats were divided in to two groups: 1) Mild Diabetes (STZ) - received streptozotocin (glycemia from 120 to 300 mg/dL), 2) Control - received vehicle (glycemia below 120 mg/dL). At days 0, 7, 14 and 21 of the pregnancy, body weight and glycemia were evaluated. At day 21 of the pregnancy, the rats were anesthetized for blood and liver collection so as to determine insulin and liver glycogen, which showed no changes in the STZ group as compared to the controls. In the STZ group, maternal weight gain were lower as compared to those in the control group. Significantly increased glycemia was observed at days 0 and 14 of the pregnancy in the STZ group. Therefore, neonatally induced diabetes in the rats did not cause metabolic changes that impaired insulin and liver glycogen relation in these rats. |
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Neonatally induced diabetes: liver glycogen storage in pregnant ratspregnancyrathyperglycemiaglycogen storage livermild diabeteshyperglycemiaThe aim of this sstudy was to evaluate the liver glycogen storage in pregnant rats presenting neonatal streptozotocin-induced diabetes and to establish a relation with glycemia and insulin levels. Wistar rats were divided in to two groups: 1) Mild Diabetes (STZ) - received streptozotocin (glycemia from 120 to 300 mg/dL), 2) Control - received vehicle (glycemia below 120 mg/dL). At days 0, 7, 14 and 21 of the pregnancy, body weight and glycemia were evaluated. At day 21 of the pregnancy, the rats were anesthetized for blood and liver collection so as to determine insulin and liver glycogen, which showed no changes in the STZ group as compared to the controls. In the STZ group, maternal weight gain were lower as compared to those in the control group. Significantly increased glycemia was observed at days 0 and 14 of the pregnancy in the STZ group. Therefore, neonatally induced diabetes in the rats did not cause metabolic changes that impaired insulin and liver glycogen relation in these rats.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Estadual Paulista Departamento de Ginecologia e Obstetrícia Laboratório de Pesquisa Experimental de Ginecologia e ObstetríciaUniversidade Sagrado Coração Departamento de Ciências Biológicas Laboratório de BiologiaUniversidade Estadual Paulista Departamento de Ginecologia e Obstetrícia Laboratório de Pesquisa Experimental de Ginecologia e ObstetríciaBrazilian Archives of Biology and TechnologyUniversidade Estadual Paulista (Unesp)Universidade Sagrado Coração Departamento de Ciências Biológicas Laboratório de BiologiaIessi, Isabela Lovizutto [UNESP]Bueno, Aline [UNESP]Sinzato, Yuri Karen [UNESP]Spada, Ana Paula Machado [UNESP]Rudge, Marilza Vieira Cunha [UNESP]Heubel, Maricê Thereza Correa DominguesDamasceno, Débora Cristina [UNESP]2014-05-20T13:35:11Z2014-05-20T13:35:11Z2012-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article251-256application/pdfhttp://dx.doi.org/10.1590/S1516-89132012000200010Brazilian Archives of Biology and Technology. Brazilian Archives of Biology and Technology, v. 55, n. 2, p. 251-256, 2012.1516-8913http://hdl.handle.net/11449/1208810.1590/S1516-89132012000200010S1516-89132012000200010WOS:000303935600010S1516-89132012000200010.pdf67586803888350780000-0002-9227-832XSciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Archives of Biology and Technology0.6760,281info:eu-repo/semantics/openAccess2024-08-16T14:12:31Zoai:repositorio.unesp.br:11449/12088Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T14:12:31Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Neonatally induced diabetes: liver glycogen storage in pregnant rats |
title |
Neonatally induced diabetes: liver glycogen storage in pregnant rats |
spellingShingle |
Neonatally induced diabetes: liver glycogen storage in pregnant rats Iessi, Isabela Lovizutto [UNESP] pregnancy rat hyperglycemia glycogen storage liver mild diabetes hyperglycemia |
title_short |
Neonatally induced diabetes: liver glycogen storage in pregnant rats |
title_full |
Neonatally induced diabetes: liver glycogen storage in pregnant rats |
title_fullStr |
Neonatally induced diabetes: liver glycogen storage in pregnant rats |
title_full_unstemmed |
Neonatally induced diabetes: liver glycogen storage in pregnant rats |
title_sort |
Neonatally induced diabetes: liver glycogen storage in pregnant rats |
author |
Iessi, Isabela Lovizutto [UNESP] |
author_facet |
Iessi, Isabela Lovizutto [UNESP] Bueno, Aline [UNESP] Sinzato, Yuri Karen [UNESP] Spada, Ana Paula Machado [UNESP] Rudge, Marilza Vieira Cunha [UNESP] Heubel, Maricê Thereza Correa Domingues Damasceno, Débora Cristina [UNESP] |
author_role |
author |
author2 |
Bueno, Aline [UNESP] Sinzato, Yuri Karen [UNESP] Spada, Ana Paula Machado [UNESP] Rudge, Marilza Vieira Cunha [UNESP] Heubel, Maricê Thereza Correa Domingues Damasceno, Débora Cristina [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Sagrado Coração Departamento de Ciências Biológicas Laboratório de Biologia |
dc.contributor.author.fl_str_mv |
Iessi, Isabela Lovizutto [UNESP] Bueno, Aline [UNESP] Sinzato, Yuri Karen [UNESP] Spada, Ana Paula Machado [UNESP] Rudge, Marilza Vieira Cunha [UNESP] Heubel, Maricê Thereza Correa Domingues Damasceno, Débora Cristina [UNESP] |
dc.subject.por.fl_str_mv |
pregnancy rat hyperglycemia glycogen storage liver mild diabetes hyperglycemia |
topic |
pregnancy rat hyperglycemia glycogen storage liver mild diabetes hyperglycemia |
description |
The aim of this sstudy was to evaluate the liver glycogen storage in pregnant rats presenting neonatal streptozotocin-induced diabetes and to establish a relation with glycemia and insulin levels. Wistar rats were divided in to two groups: 1) Mild Diabetes (STZ) - received streptozotocin (glycemia from 120 to 300 mg/dL), 2) Control - received vehicle (glycemia below 120 mg/dL). At days 0, 7, 14 and 21 of the pregnancy, body weight and glycemia were evaluated. At day 21 of the pregnancy, the rats were anesthetized for blood and liver collection so as to determine insulin and liver glycogen, which showed no changes in the STZ group as compared to the controls. In the STZ group, maternal weight gain were lower as compared to those in the control group. Significantly increased glycemia was observed at days 0 and 14 of the pregnancy in the STZ group. Therefore, neonatally induced diabetes in the rats did not cause metabolic changes that impaired insulin and liver glycogen relation in these rats. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-04-01 2014-05-20T13:35:11Z 2014-05-20T13:35:11Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1516-89132012000200010 Brazilian Archives of Biology and Technology. Brazilian Archives of Biology and Technology, v. 55, n. 2, p. 251-256, 2012. 1516-8913 http://hdl.handle.net/11449/12088 10.1590/S1516-89132012000200010 S1516-89132012000200010 WOS:000303935600010 S1516-89132012000200010.pdf 6758680388835078 0000-0002-9227-832X |
url |
http://dx.doi.org/10.1590/S1516-89132012000200010 http://hdl.handle.net/11449/12088 |
identifier_str_mv |
Brazilian Archives of Biology and Technology. Brazilian Archives of Biology and Technology, v. 55, n. 2, p. 251-256, 2012. 1516-8913 10.1590/S1516-89132012000200010 S1516-89132012000200010 WOS:000303935600010 S1516-89132012000200010.pdf 6758680388835078 0000-0002-9227-832X |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Archives of Biology and Technology 0.676 0,281 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
251-256 application/pdf |
dc.publisher.none.fl_str_mv |
Brazilian Archives of Biology and Technology |
publisher.none.fl_str_mv |
Brazilian Archives of Biology and Technology |
dc.source.none.fl_str_mv |
SciELO reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128176297082880 |