Neonatally induced diabetes: liver glycogen storage in pregnant rats

Detalhes bibliográficos
Autor(a) principal: Iessi, Isabela Lovizutto [UNESP]
Data de Publicação: 2012
Outros Autores: Bueno, Aline [UNESP], Sinzato, Yuri Karen [UNESP], Spada, Ana Paula Machado [UNESP], Rudge, Marilza Vieira Cunha [UNESP], Heubel, Maricê Thereza Correa Domingues, Damasceno, Débora Cristina [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S1516-89132012000200010
http://hdl.handle.net/11449/12088
Resumo: The aim of this sstudy was to evaluate the liver glycogen storage in pregnant rats presenting neonatal streptozotocin-induced diabetes and to establish a relation with glycemia and insulin levels. Wistar rats were divided in to two groups: 1) Mild Diabetes (STZ) - received streptozotocin (glycemia from 120 to 300 mg/dL), 2) Control - received vehicle (glycemia below 120 mg/dL). At days 0, 7, 14 and 21 of the pregnancy, body weight and glycemia were evaluated. At day 21 of the pregnancy, the rats were anesthetized for blood and liver collection so as to determine insulin and liver glycogen, which showed no changes in the STZ group as compared to the controls. In the STZ group, maternal weight gain were lower as compared to those in the control group. Significantly increased glycemia was observed at days 0 and 14 of the pregnancy in the STZ group. Therefore, neonatally induced diabetes in the rats did not cause metabolic changes that impaired insulin and liver glycogen relation in these rats.
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spelling Neonatally induced diabetes: liver glycogen storage in pregnant ratspregnancyrathyperglycemiaglycogen storage livermild diabeteshyperglycemiaThe aim of this sstudy was to evaluate the liver glycogen storage in pregnant rats presenting neonatal streptozotocin-induced diabetes and to establish a relation with glycemia and insulin levels. Wistar rats were divided in to two groups: 1) Mild Diabetes (STZ) - received streptozotocin (glycemia from 120 to 300 mg/dL), 2) Control - received vehicle (glycemia below 120 mg/dL). At days 0, 7, 14 and 21 of the pregnancy, body weight and glycemia were evaluated. At day 21 of the pregnancy, the rats were anesthetized for blood and liver collection so as to determine insulin and liver glycogen, which showed no changes in the STZ group as compared to the controls. In the STZ group, maternal weight gain were lower as compared to those in the control group. Significantly increased glycemia was observed at days 0 and 14 of the pregnancy in the STZ group. Therefore, neonatally induced diabetes in the rats did not cause metabolic changes that impaired insulin and liver glycogen relation in these rats.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Estadual Paulista Departamento de Ginecologia e Obstetrícia Laboratório de Pesquisa Experimental de Ginecologia e ObstetríciaUniversidade Sagrado Coração Departamento de Ciências Biológicas Laboratório de BiologiaUniversidade Estadual Paulista Departamento de Ginecologia e Obstetrícia Laboratório de Pesquisa Experimental de Ginecologia e ObstetríciaBrazilian Archives of Biology and TechnologyUniversidade Estadual Paulista (Unesp)Universidade Sagrado Coração Departamento de Ciências Biológicas Laboratório de BiologiaIessi, Isabela Lovizutto [UNESP]Bueno, Aline [UNESP]Sinzato, Yuri Karen [UNESP]Spada, Ana Paula Machado [UNESP]Rudge, Marilza Vieira Cunha [UNESP]Heubel, Maricê Thereza Correa DominguesDamasceno, Débora Cristina [UNESP]2014-05-20T13:35:11Z2014-05-20T13:35:11Z2012-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article251-256application/pdfhttp://dx.doi.org/10.1590/S1516-89132012000200010Brazilian Archives of Biology and Technology. Brazilian Archives of Biology and Technology, v. 55, n. 2, p. 251-256, 2012.1516-8913http://hdl.handle.net/11449/1208810.1590/S1516-89132012000200010S1516-89132012000200010WOS:000303935600010S1516-89132012000200010.pdf67586803888350780000-0002-9227-832XSciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Archives of Biology and Technology0.6760,281info:eu-repo/semantics/openAccess2024-08-16T14:12:31Zoai:repositorio.unesp.br:11449/12088Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T14:12:31Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Neonatally induced diabetes: liver glycogen storage in pregnant rats
title Neonatally induced diabetes: liver glycogen storage in pregnant rats
spellingShingle Neonatally induced diabetes: liver glycogen storage in pregnant rats
Iessi, Isabela Lovizutto [UNESP]
pregnancy
rat
hyperglycemia
glycogen storage liver
mild diabetes
hyperglycemia
title_short Neonatally induced diabetes: liver glycogen storage in pregnant rats
title_full Neonatally induced diabetes: liver glycogen storage in pregnant rats
title_fullStr Neonatally induced diabetes: liver glycogen storage in pregnant rats
title_full_unstemmed Neonatally induced diabetes: liver glycogen storage in pregnant rats
title_sort Neonatally induced diabetes: liver glycogen storage in pregnant rats
author Iessi, Isabela Lovizutto [UNESP]
author_facet Iessi, Isabela Lovizutto [UNESP]
Bueno, Aline [UNESP]
Sinzato, Yuri Karen [UNESP]
Spada, Ana Paula Machado [UNESP]
Rudge, Marilza Vieira Cunha [UNESP]
Heubel, Maricê Thereza Correa Domingues
Damasceno, Débora Cristina [UNESP]
author_role author
author2 Bueno, Aline [UNESP]
Sinzato, Yuri Karen [UNESP]
Spada, Ana Paula Machado [UNESP]
Rudge, Marilza Vieira Cunha [UNESP]
Heubel, Maricê Thereza Correa Domingues
Damasceno, Débora Cristina [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade Sagrado Coração Departamento de Ciências Biológicas Laboratório de Biologia
dc.contributor.author.fl_str_mv Iessi, Isabela Lovizutto [UNESP]
Bueno, Aline [UNESP]
Sinzato, Yuri Karen [UNESP]
Spada, Ana Paula Machado [UNESP]
Rudge, Marilza Vieira Cunha [UNESP]
Heubel, Maricê Thereza Correa Domingues
Damasceno, Débora Cristina [UNESP]
dc.subject.por.fl_str_mv pregnancy
rat
hyperglycemia
glycogen storage liver
mild diabetes
hyperglycemia
topic pregnancy
rat
hyperglycemia
glycogen storage liver
mild diabetes
hyperglycemia
description The aim of this sstudy was to evaluate the liver glycogen storage in pregnant rats presenting neonatal streptozotocin-induced diabetes and to establish a relation with glycemia and insulin levels. Wistar rats were divided in to two groups: 1) Mild Diabetes (STZ) - received streptozotocin (glycemia from 120 to 300 mg/dL), 2) Control - received vehicle (glycemia below 120 mg/dL). At days 0, 7, 14 and 21 of the pregnancy, body weight and glycemia were evaluated. At day 21 of the pregnancy, the rats were anesthetized for blood and liver collection so as to determine insulin and liver glycogen, which showed no changes in the STZ group as compared to the controls. In the STZ group, maternal weight gain were lower as compared to those in the control group. Significantly increased glycemia was observed at days 0 and 14 of the pregnancy in the STZ group. Therefore, neonatally induced diabetes in the rats did not cause metabolic changes that impaired insulin and liver glycogen relation in these rats.
publishDate 2012
dc.date.none.fl_str_mv 2012-04-01
2014-05-20T13:35:11Z
2014-05-20T13:35:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1516-89132012000200010
Brazilian Archives of Biology and Technology. Brazilian Archives of Biology and Technology, v. 55, n. 2, p. 251-256, 2012.
1516-8913
http://hdl.handle.net/11449/12088
10.1590/S1516-89132012000200010
S1516-89132012000200010
WOS:000303935600010
S1516-89132012000200010.pdf
6758680388835078
0000-0002-9227-832X
url http://dx.doi.org/10.1590/S1516-89132012000200010
http://hdl.handle.net/11449/12088
identifier_str_mv Brazilian Archives of Biology and Technology. Brazilian Archives of Biology and Technology, v. 55, n. 2, p. 251-256, 2012.
1516-8913
10.1590/S1516-89132012000200010
S1516-89132012000200010
WOS:000303935600010
S1516-89132012000200010.pdf
6758680388835078
0000-0002-9227-832X
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Archives of Biology and Technology
0.676
0,281
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 251-256
application/pdf
dc.publisher.none.fl_str_mv Brazilian Archives of Biology and Technology
publisher.none.fl_str_mv Brazilian Archives of Biology and Technology
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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