Effect of medicinal plants on the parasitemia of Trypanosoma cruzi and on the biodistribution of sodium pertechnetate (Na99mTcO4)

• Autor(a) principal: Silva,Roseane Pereira da
• Data de Publicação: 2008
• Outros Autores: Holanda,Cecília Maria de Carvalho Xavier, Barbosa,Vanessa Santos de Arruda, Oliveira,Daniel Pereira de, Lima,Natália Alves, Câmara,Antônia Cláudia Jácome da, Medeiros,Aldo da Cunha, Constantino,Maria Helena Spyrides
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Brazilian Archives of Biology and Technology
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700034
• topic: Aloe vera; Artemisia vulgaris; technetium-99m; Trypanosoma cruzi; parasitemia; biodistribution

Artemisia vulgaris (AV) is an antihelmintic and antimalarial drug; Aloe vera(babosa) acts as antidiabetic, laxative and anti-inflammatory;Benznidazole (BZ) is a trypanocidal of Trypanosoma cruzi (TC). Technetium-99m (99mTc) has been used in nuclear medicine to obtain diagnostic images. This study evaluated the plant effects in TC parasitemia and on the biodistribution of 99mTc in mice. Twenty mice were infected by TC. At the peak of parasitemia, 5 mice received babosa; 5 received AV and 5 received BZ. The parasitemia was determined at 0, 2, 4 and 6 h of drugs administration. Five infected mice without drugs, 5 mice without TC and the group treated with AV, received 99mTc. The radioactivity was calculated. Infected mice that received babosa reduced significantly (p<0.05) the TC parasitemia. The percentage of activity per gram (%ATI/g) decreased significantly on the AV group. These results indicate that babosa possibly is an anti-TC drug and AV reduces the %ATI/g probably due to its biological effects.