Effect of Tripanosomicide Benznidazole (Rochagan®) on the Biodistribution of Sodium Pertechnetate (Na99mTcO4) in Wistar Rats

Detalhes bibliográficos
Autor(a) principal: Barbosa, Vanessa Santos de Arruda
Data de Publicação: 2008
Outros Autores: Holanda, Cecília Maria de Carvalho Xavier, Silva, Roseane Pereira da, Oliveira, Daniel Pereira de, Silva Júnior, Maurício Ferreira da, Oliveira, Elias Herculano de, Spyrides, Maria Helena Constantino, Medeiros, Aldo Cunha
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/jspui/handle/1/6282
Resumo: Benznidazole, a drug with specific anti-Trypanosoma cruzi activity, is used in the treatment of Chagas’ disease. The radiopharmaceutical sodium pertechnetate (Na99mTcO4) is used to obtain diagnostic images of the stomach, thyroid, parathyroids, salivary glands, brain and in the study of esophageal reflux and blood flow. This study aimed at evaluating in vivo the influence of benznidazole treatment on the sodium pertechnetate biodistribution in Wistar rats. The percentage of radioactivity per gram (%ATI/g) of various organs (brain, heart, esophagus, stomach, small intestine, large intestine, spleen, liver, muscle and blood) was determined. Comparing the treated rats with the controls, we observed that sodium pertechnetate biodistribution did not change when administered to rats treated for thirty days with benznidazole
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spelling Barbosa, Vanessa Santos de ArrudaHolanda, Cecília Maria de Carvalho XavierSilva, Roseane Pereira daOliveira, Daniel Pereira deSilva Júnior, Maurício Ferreira daOliveira, Elias Herculano deSpyrides, Maria Helena ConstantinoMedeiros, Aldo Cunha2013-09-24T17:34:12Z2013-09-24T17:34:12Z2008BARBOSA, Vanessa Santos de Arruda ; HOLANDA, Cecília Maria de Carvalho Xavier ; SILVA, Roseane Pereira da ; OLIVEIRA, Daniel Pereira de ; SILVA JÚNIOR, Maurício Ferreira da ; OLIVEIRA, Elias Herculano de ; SPYRIDES, Maria Helena Constantino ; MEDEIROS, Aldo Cunha. Effect of tripanosomicide benznidazole (Rochagan ) on the biodistribution of sodium pertechnetate (Na99mTcO4) in Wistar rats. Brazilian Archives of Biology and Technology , v. 51, p. 175-180, 2008. Disponível em: <http://www.scielo.br/scielo.php?pid=s1516-89132008000700028&script=sci_arttext>. Acesso em: 19 set. 2013.1516-8913https://repositorio.ufrn.br/jspui/handle/1/6282Benznidazole, a drug with specific anti-Trypanosoma cruzi activity, is used in the treatment of Chagas’ disease. The radiopharmaceutical sodium pertechnetate (Na99mTcO4) is used to obtain diagnostic images of the stomach, thyroid, parathyroids, salivary glands, brain and in the study of esophageal reflux and blood flow. This study aimed at evaluating in vivo the influence of benznidazole treatment on the sodium pertechnetate biodistribution in Wistar rats. The percentage of radioactivity per gram (%ATI/g) of various organs (brain, heart, esophagus, stomach, small intestine, large intestine, spleen, liver, muscle and blood) was determined. 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dc.title.pt_BR.fl_str_mv Effect of Tripanosomicide Benznidazole (Rochagan®) on the Biodistribution of Sodium Pertechnetate (Na99mTcO4) in Wistar Rats
title Effect of Tripanosomicide Benznidazole (Rochagan®) on the Biodistribution of Sodium Pertechnetate (Na99mTcO4) in Wistar Rats
spellingShingle Effect of Tripanosomicide Benznidazole (Rochagan®) on the Biodistribution of Sodium Pertechnetate (Na99mTcO4) in Wistar Rats
Barbosa, Vanessa Santos de Arruda
Antiparasite
Radiopharmaceutical
Technetium-99m
Benznidazole
Biodistribution
Trypanosoma cruzi
title_short Effect of Tripanosomicide Benznidazole (Rochagan®) on the Biodistribution of Sodium Pertechnetate (Na99mTcO4) in Wistar Rats
title_full Effect of Tripanosomicide Benznidazole (Rochagan®) on the Biodistribution of Sodium Pertechnetate (Na99mTcO4) in Wistar Rats
title_fullStr Effect of Tripanosomicide Benznidazole (Rochagan®) on the Biodistribution of Sodium Pertechnetate (Na99mTcO4) in Wistar Rats
title_full_unstemmed Effect of Tripanosomicide Benznidazole (Rochagan®) on the Biodistribution of Sodium Pertechnetate (Na99mTcO4) in Wistar Rats
title_sort Effect of Tripanosomicide Benznidazole (Rochagan®) on the Biodistribution of Sodium Pertechnetate (Na99mTcO4) in Wistar Rats
author Barbosa, Vanessa Santos de Arruda
author_facet Barbosa, Vanessa Santos de Arruda
Holanda, Cecília Maria de Carvalho Xavier
Silva, Roseane Pereira da
Oliveira, Daniel Pereira de
Silva Júnior, Maurício Ferreira da
Oliveira, Elias Herculano de
Spyrides, Maria Helena Constantino
Medeiros, Aldo Cunha
author_role author
author2 Holanda, Cecília Maria de Carvalho Xavier
Silva, Roseane Pereira da
Oliveira, Daniel Pereira de
Silva Júnior, Maurício Ferreira da
Oliveira, Elias Herculano de
Spyrides, Maria Helena Constantino
Medeiros, Aldo Cunha
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Barbosa, Vanessa Santos de Arruda
Holanda, Cecília Maria de Carvalho Xavier
Silva, Roseane Pereira da
Oliveira, Daniel Pereira de
Silva Júnior, Maurício Ferreira da
Oliveira, Elias Herculano de
Spyrides, Maria Helena Constantino
Medeiros, Aldo Cunha
dc.subject.por.fl_str_mv Antiparasite
Radiopharmaceutical
Technetium-99m
Benznidazole
Biodistribution
Trypanosoma cruzi
topic Antiparasite
Radiopharmaceutical
Technetium-99m
Benznidazole
Biodistribution
Trypanosoma cruzi
description Benznidazole, a drug with specific anti-Trypanosoma cruzi activity, is used in the treatment of Chagas’ disease. The radiopharmaceutical sodium pertechnetate (Na99mTcO4) is used to obtain diagnostic images of the stomach, thyroid, parathyroids, salivary glands, brain and in the study of esophageal reflux and blood flow. This study aimed at evaluating in vivo the influence of benznidazole treatment on the sodium pertechnetate biodistribution in Wistar rats. The percentage of radioactivity per gram (%ATI/g) of various organs (brain, heart, esophagus, stomach, small intestine, large intestine, spleen, liver, muscle and blood) was determined. Comparing the treated rats with the controls, we observed that sodium pertechnetate biodistribution did not change when administered to rats treated for thirty days with benznidazole
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2013-09-24T17:34:12Z
dc.date.available.fl_str_mv 2013-09-24T17:34:12Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv BARBOSA, Vanessa Santos de Arruda ; HOLANDA, Cecília Maria de Carvalho Xavier ; SILVA, Roseane Pereira da ; OLIVEIRA, Daniel Pereira de ; SILVA JÚNIOR, Maurício Ferreira da ; OLIVEIRA, Elias Herculano de ; SPYRIDES, Maria Helena Constantino ; MEDEIROS, Aldo Cunha. Effect of tripanosomicide benznidazole (Rochagan ) on the biodistribution of sodium pertechnetate (Na99mTcO4) in Wistar rats. Brazilian Archives of Biology and Technology , v. 51, p. 175-180, 2008. Disponível em: <http://www.scielo.br/scielo.php?pid=s1516-89132008000700028&script=sci_arttext>. Acesso em: 19 set. 2013.
dc.identifier.uri.fl_str_mv https://repositorio.ufrn.br/jspui/handle/1/6282
dc.identifier.issn.none.fl_str_mv 1516-8913
identifier_str_mv BARBOSA, Vanessa Santos de Arruda ; HOLANDA, Cecília Maria de Carvalho Xavier ; SILVA, Roseane Pereira da ; OLIVEIRA, Daniel Pereira de ; SILVA JÚNIOR, Maurício Ferreira da ; OLIVEIRA, Elias Herculano de ; SPYRIDES, Maria Helena Constantino ; MEDEIROS, Aldo Cunha. Effect of tripanosomicide benznidazole (Rochagan ) on the biodistribution of sodium pertechnetate (Na99mTcO4) in Wistar rats. Brazilian Archives of Biology and Technology , v. 51, p. 175-180, 2008. Disponível em: <http://www.scielo.br/scielo.php?pid=s1516-89132008000700028&script=sci_arttext>. Acesso em: 19 set. 2013.
1516-8913
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