Candidemias e a resistência aos antifúngicos

Detalhes bibliográficos
Autor(a) principal: Araújo, Flávia Caixêta
Data de Publicação: 2013
Idioma: por
Título da fonte: Repositório Institucional da UCB
Texto Completo: https://repositorio.ucb.br:9443/jspui/handle/10869/2757
Resumo: Biomedicina
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spelling Araújo, Flávia Caixêta2014-03-21T20:17:29Z2016-10-10T03:42:03Z2014-03-21T20:17:29Z2016-10-10T03:42:03Z2013-11-14ARAÚJO, Flávia Caixêta. Candidemias e a resistência aos antifúngicos. 2013. 26 f. Monografia (Graduação) - Universidade Católica de Brasília, Brasília, 2013.https://repositorio.ucb.br:9443/jspui/handle/10869/2757BiomedicinaAs infecções fúngicas invasivas causadas por Candida sp., também conhecidas como candidemias ou candidíases hematogênicas, aumentam a cada dia. Os grupos mais suscetíveis a essas infecções são os imunodeprimidos, neonatos de baixo peso e que estão sujeitos a condições hospitalares propícias, além dos idosos. Ainda são descritos como grupos de risco, pacientes em uso de antibióticos de largo espectro, uso de cateter venoso central e ventilação mecânica. A espécie mais comum causadora de candidemias é a Candida albicans, seguida por C. tropicalis, C. glabrata e C. parapsilosis. Mas sabe-se que várias espécies não patogênicas vêm emergindo como patógenos oportunistas, elevando a lista para 18 espécies descritas. A terapêutica se baseia no uso de antifúngicos, sendo 3 classes mais utilizadas, os azólicos (imidazólicos e triazólicos), antibióticos poliênicos e equinocandinas. Porém, muitas espécies apresentam resistência frente esses fármacos, o que dificulta o tratamento e eleva as chances de mortalidade dos pacientes. Devido a isso, a necessidade de metodologias para avaliação da resistência a antifúngicos vem surgindo, com o intuito de aplicar a terapêutica mais adequada a cada paciente.Invasive fungal infections caused by Candida sp., also known as candidemias or hematogenous candidiasis, are increasing every day. The groups more susceptible to these infections are immunosuppressed, newborns of low birth weight and that are subject to hospital conditions conducive, in addition to the elderly. Are still described as risk groups, patients using broad-spectrum antibiotics, use of central venous catheter and mechanical ventilation. The most common species causing candidemias is Candida albicans, followed by C. tropicalis, C. parapsilosis and C. glabrata. But it is known that several pathogenic species are emerging as opportunistic pathogens, bringing the list to 18 described species. The therapy is based on the use of antifungals, 3 more classes being used, the azole (imidazolyl and triazólicos), polienics antibiotics and equinocandinas. However, many species exhibit resistance these pharmaceuticals, which makes the treatment and raises the chances of the mortality of patients. Because of this, the need for methodologies for assessment of resistance to antifungals comes popping up, in order to apply the most appropriate therapy for each patient.Submitted by Juliana Pereira (juliana.pereira@ucb.br) on 2014-03-14T14:40:06Z No. of bitstreams: 2 license_rdf: 20168 bytes, checksum: 288037d582f66c131a3b54761360a7bc (MD5) TCC II - Flavia Caixeta Arapujo.pdf: 416330 bytes, checksum: 4dbff37a880f195584b521305f8ee283 (MD5)Approved for entry into archive by Kelson Anthony de Menezes(kelson@ucb.br) on 2014-03-21T20:17:29Z (GMT) No. of bitstreams: 2 license_rdf: 20168 bytes, checksum: 288037d582f66c131a3b54761360a7bc (MD5) TCC II - Flavia Caixeta Arapujo.pdf: 416330 bytes, checksum: 4dbff37a880f195584b521305f8ee283 (MD5)Made available in DSpace on 2014-03-21T20:17:29Z (GMT). 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dc.title.pt_BR.fl_str_mv Candidemias e a resistência aos antifúngicos
title Candidemias e a resistência aos antifúngicos
spellingShingle Candidemias e a resistência aos antifúngicos
Araújo, Flávia Caixêta
Candidíase hematogênica
Candidemia
Fungemia
Biomedicina
Hematogenous candidiasis
Candidemia
Fungemia
title_short Candidemias e a resistência aos antifúngicos
title_full Candidemias e a resistência aos antifúngicos
title_fullStr Candidemias e a resistência aos antifúngicos
title_full_unstemmed Candidemias e a resistência aos antifúngicos
title_sort Candidemias e a resistência aos antifúngicos
author Araújo, Flávia Caixêta
author_facet Araújo, Flávia Caixêta
author_role author
dc.contributor.author.fl_str_mv Araújo, Flávia Caixêta
dc.subject.por.fl_str_mv Candidíase hematogênica
Candidemia
Fungemia
Biomedicina
Hematogenous candidiasis
Candidemia
Fungemia
topic Candidíase hematogênica
Candidemia
Fungemia
Biomedicina
Hematogenous candidiasis
Candidemia
Fungemia
dc.description.pt_BR.fl_txt_mv Biomedicina
dc.description.abstract.por.fl_txt_mv As infecções fúngicas invasivas causadas por Candida sp., também conhecidas como candidemias ou candidíases hematogênicas, aumentam a cada dia. Os grupos mais suscetíveis a essas infecções são os imunodeprimidos, neonatos de baixo peso e que estão sujeitos a condições hospitalares propícias, além dos idosos. Ainda são descritos como grupos de risco, pacientes em uso de antibióticos de largo espectro, uso de cateter venoso central e ventilação mecânica. A espécie mais comum causadora de candidemias é a Candida albicans, seguida por C. tropicalis, C. glabrata e C. parapsilosis. Mas sabe-se que várias espécies não patogênicas vêm emergindo como patógenos oportunistas, elevando a lista para 18 espécies descritas. A terapêutica se baseia no uso de antifúngicos, sendo 3 classes mais utilizadas, os azólicos (imidazólicos e triazólicos), antibióticos poliênicos e equinocandinas. Porém, muitas espécies apresentam resistência frente esses fármacos, o que dificulta o tratamento e eleva as chances de mortalidade dos pacientes. Devido a isso, a necessidade de metodologias para avaliação da resistência a antifúngicos vem surgindo, com o intuito de aplicar a terapêutica mais adequada a cada paciente.
Invasive fungal infections caused by Candida sp., also known as candidemias or hematogenous candidiasis, are increasing every day. The groups more susceptible to these infections are immunosuppressed, newborns of low birth weight and that are subject to hospital conditions conducive, in addition to the elderly. Are still described as risk groups, patients using broad-spectrum antibiotics, use of central venous catheter and mechanical ventilation. The most common species causing candidemias is Candida albicans, followed by C. tropicalis, C. parapsilosis and C. glabrata. But it is known that several pathogenic species are emerging as opportunistic pathogens, bringing the list to 18 described species. The therapy is based on the use of antifungals, 3 more classes being used, the azole (imidazolyl and triazólicos), polienics antibiotics and equinocandinas. However, many species exhibit resistance these pharmaceuticals, which makes the treatment and raises the chances of the mortality of patients. Because of this, the need for methodologies for assessment of resistance to antifungals comes popping up, in order to apply the most appropriate therapy for each patient.
description Biomedicina
publishDate 2013
dc.date.issued.fl_str_mv 2013-11-14
dc.date.accessioned.fl_str_mv 2014-03-21T20:17:29Z
2016-10-10T03:42:03Z
dc.date.available.fl_str_mv 2014-03-21T20:17:29Z
2016-10-10T03:42:03Z
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dc.identifier.citation.fl_str_mv ARAÚJO, Flávia Caixêta. Candidemias e a resistência aos antifúngicos. 2013. 26 f. Monografia (Graduação) - Universidade Católica de Brasília, Brasília, 2013.
dc.identifier.uri.fl_str_mv https://repositorio.ucb.br:9443/jspui/handle/10869/2757
identifier_str_mv ARAÚJO, Flávia Caixêta. Candidemias e a resistência aos antifúngicos. 2013. 26 f. Monografia (Graduação) - Universidade Católica de Brasília, Brasília, 2013.
url https://repositorio.ucb.br:9443/jspui/handle/10869/2757
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