RHEUMATOID ARTHRITIS-INCREASED GENE EXPRESSIONS IN MUSCLE ATROPHY ARE RESTORED BACK TO CONTROL AS A RESPONSE TO ACUTE RESISTANCE EXERCISE

Detalhes bibliográficos
Autor(a) principal: Oliveira, Anselmo Alves
Data de Publicação: 2018
Outros Autores: Martins, Fernanda Maria, Furlanetto Júnior, Roberto, Michelin, Márcia Antoniazi, Sousa, Aletéia Paula, Nunes, Paulo Ricardo Prado, Murta, Eddie Fernando Candido, Chica, Javier Emilio Lazo, Orsatti, Fábio Lera
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Ciência e Movimento (Online)
Texto Completo: https://portalrevistas.ucb.br/index.php/rbcm/article/view/7928
Resumo: This study had as objective to analyze the acute effects of resistance exercise (RE) on the mRNA levels of the following genes (MyoD, myogenin, IGF-1, atrogin-1, MuRF-1, and myostatin) in rheumatoid arthritis (experimental arthritis). Therefore, 26 females rats were randomly allocated into four groups, control (CT, n=7), exercise (Ex, n=6), rheumatoid arthritis (RA, n=6) and RA with exercise (RAEx, n=7). Met-BSA was injected into the tibiotarsal joint in the RA and RAEx groups. After 15 days from injection, the animals were submitted to an acute bout of RE and six hours post protocol the animals were euthanized. We evaluated the joint thickness, inflammation score, cross-sectional area (CSA) of gastrocnemius muscle fibers and mRNA expression of the IGF-1, MyoD, myogenin, myostatin, MuRF-1, atrogin-1 and GAPDH. It was observed that the joint thickness and score strongly increased in arthritic rats (p
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spelling RHEUMATOID ARTHRITIS-INCREASED GENE EXPRESSIONS IN MUSCLE ATROPHY ARE RESTORED BACK TO CONTROL AS A RESPONSE TO ACUTE RESISTANCE EXERCISEThis study had as objective to analyze the acute effects of resistance exercise (RE) on the mRNA levels of the following genes (MyoD, myogenin, IGF-1, atrogin-1, MuRF-1, and myostatin) in rheumatoid arthritis (experimental arthritis). Therefore, 26 females rats were randomly allocated into four groups, control (CT, n=7), exercise (Ex, n=6), rheumatoid arthritis (RA, n=6) and RA with exercise (RAEx, n=7). Met-BSA was injected into the tibiotarsal joint in the RA and RAEx groups. After 15 days from injection, the animals were submitted to an acute bout of RE and six hours post protocol the animals were euthanized. We evaluated the joint thickness, inflammation score, cross-sectional area (CSA) of gastrocnemius muscle fibers and mRNA expression of the IGF-1, MyoD, myogenin, myostatin, MuRF-1, atrogin-1 and GAPDH. It was observed that the joint thickness and score strongly increased in arthritic rats (p Universidade Católica de Brasília2018-07-25info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionTransversalAvaliado por Paresapplication/pdfapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/vnd.openxmlformats-officedocument.wordprocessingml.documenthttps://portalrevistas.ucb.br/index.php/rbcm/article/view/792810.31501/rbcm.v26i2.7928Revista Brasileira de Ciência e Movimento; v. 26 n. 2 (2018); 24-330103-171610.31501/rbcm.v26i2reponame:Revista Brasileira de Ciência e Movimento (Online)instname:Universidade Católica de Brasília (UCB)instacron:UCBenghttps://portalrevistas.ucb.br/index.php/rbcm/article/view/7928/5794https://portalrevistas.ucb.br/index.php/rbcm/article/view/7928/9756https://portalrevistas.ucb.br/index.php/rbcm/article/view/7928/9757https://portalrevistas.ucb.br/index.php/rbcm/article/view/7928/9758Copyright (c) 2018 Revista Brasileira de Ciência e Movimentoinfo:eu-repo/semantics/openAccessOliveira, Anselmo AlvesMartins, Fernanda MariaFurlanetto Júnior, RobertoMichelin, Márcia AntoniaziSousa, Aletéia PaulaNunes, Paulo Ricardo PradoMurta, Eddie Fernando CandidoChica, Javier Emilio LazoOrsatti, Fábio Lera2018-08-20T15:51:59Zoai:ojs.portalrevistas.ucb.br:article/7928Revistahttp://portalrevistas.ucb.br/index.php/RBCMPRIhttp://portalrevistas.ucb.br/index.php/RBCM/oai||jr_lazer@yahoo.com.br2237-90020103-1716opendoar:2018-08-20T15:51:59Revista Brasileira de Ciência e Movimento (Online) - Universidade Católica de Brasília (UCB)false
dc.title.none.fl_str_mv RHEUMATOID ARTHRITIS-INCREASED GENE EXPRESSIONS IN MUSCLE ATROPHY ARE RESTORED BACK TO CONTROL AS A RESPONSE TO ACUTE RESISTANCE EXERCISE
title RHEUMATOID ARTHRITIS-INCREASED GENE EXPRESSIONS IN MUSCLE ATROPHY ARE RESTORED BACK TO CONTROL AS A RESPONSE TO ACUTE RESISTANCE EXERCISE
spellingShingle RHEUMATOID ARTHRITIS-INCREASED GENE EXPRESSIONS IN MUSCLE ATROPHY ARE RESTORED BACK TO CONTROL AS A RESPONSE TO ACUTE RESISTANCE EXERCISE
Oliveira, Anselmo Alves
title_short RHEUMATOID ARTHRITIS-INCREASED GENE EXPRESSIONS IN MUSCLE ATROPHY ARE RESTORED BACK TO CONTROL AS A RESPONSE TO ACUTE RESISTANCE EXERCISE
title_full RHEUMATOID ARTHRITIS-INCREASED GENE EXPRESSIONS IN MUSCLE ATROPHY ARE RESTORED BACK TO CONTROL AS A RESPONSE TO ACUTE RESISTANCE EXERCISE
title_fullStr RHEUMATOID ARTHRITIS-INCREASED GENE EXPRESSIONS IN MUSCLE ATROPHY ARE RESTORED BACK TO CONTROL AS A RESPONSE TO ACUTE RESISTANCE EXERCISE
title_full_unstemmed RHEUMATOID ARTHRITIS-INCREASED GENE EXPRESSIONS IN MUSCLE ATROPHY ARE RESTORED BACK TO CONTROL AS A RESPONSE TO ACUTE RESISTANCE EXERCISE
title_sort RHEUMATOID ARTHRITIS-INCREASED GENE EXPRESSIONS IN MUSCLE ATROPHY ARE RESTORED BACK TO CONTROL AS A RESPONSE TO ACUTE RESISTANCE EXERCISE
author Oliveira, Anselmo Alves
author_facet Oliveira, Anselmo Alves
Martins, Fernanda Maria
Furlanetto Júnior, Roberto
Michelin, Márcia Antoniazi
Sousa, Aletéia Paula
Nunes, Paulo Ricardo Prado
Murta, Eddie Fernando Candido
Chica, Javier Emilio Lazo
Orsatti, Fábio Lera
author_role author
author2 Martins, Fernanda Maria
Furlanetto Júnior, Roberto
Michelin, Márcia Antoniazi
Sousa, Aletéia Paula
Nunes, Paulo Ricardo Prado
Murta, Eddie Fernando Candido
Chica, Javier Emilio Lazo
Orsatti, Fábio Lera
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Anselmo Alves
Martins, Fernanda Maria
Furlanetto Júnior, Roberto
Michelin, Márcia Antoniazi
Sousa, Aletéia Paula
Nunes, Paulo Ricardo Prado
Murta, Eddie Fernando Candido
Chica, Javier Emilio Lazo
Orsatti, Fábio Lera
description This study had as objective to analyze the acute effects of resistance exercise (RE) on the mRNA levels of the following genes (MyoD, myogenin, IGF-1, atrogin-1, MuRF-1, and myostatin) in rheumatoid arthritis (experimental arthritis). Therefore, 26 females rats were randomly allocated into four groups, control (CT, n=7), exercise (Ex, n=6), rheumatoid arthritis (RA, n=6) and RA with exercise (RAEx, n=7). Met-BSA was injected into the tibiotarsal joint in the RA and RAEx groups. After 15 days from injection, the animals were submitted to an acute bout of RE and six hours post protocol the animals were euthanized. We evaluated the joint thickness, inflammation score, cross-sectional area (CSA) of gastrocnemius muscle fibers and mRNA expression of the IGF-1, MyoD, myogenin, myostatin, MuRF-1, atrogin-1 and GAPDH. It was observed that the joint thickness and score strongly increased in arthritic rats (p
publishDate 2018
dc.date.none.fl_str_mv 2018-07-25
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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Avaliado por Pares
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dc.identifier.uri.fl_str_mv https://portalrevistas.ucb.br/index.php/rbcm/article/view/7928
10.31501/rbcm.v26i2.7928
url https://portalrevistas.ucb.br/index.php/rbcm/article/view/7928
identifier_str_mv 10.31501/rbcm.v26i2.7928
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://portalrevistas.ucb.br/index.php/rbcm/article/view/7928/5794
https://portalrevistas.ucb.br/index.php/rbcm/article/view/7928/9756
https://portalrevistas.ucb.br/index.php/rbcm/article/view/7928/9757
https://portalrevistas.ucb.br/index.php/rbcm/article/view/7928/9758
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista Brasileira de Ciência e Movimento
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista Brasileira de Ciência e Movimento
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Universidade Católica de Brasília
publisher.none.fl_str_mv Universidade Católica de Brasília
dc.source.none.fl_str_mv Revista Brasileira de Ciência e Movimento; v. 26 n. 2 (2018); 24-33
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reponame_str Revista Brasileira de Ciência e Movimento (Online)
collection Revista Brasileira de Ciência e Movimento (Online)
repository.name.fl_str_mv Revista Brasileira de Ciência e Movimento (Online) - Universidade Católica de Brasília (UCB)
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