AVALIAÇÃO DO EFEITO PROFILÁTICO DA β-GLUCANA LASIODIPLODANA SOBRE MODELO DE NEUROINFLAMAÇÃO, DÉFICIT COGNITIVO E ESTRESSE OXIDATIVO EM RATOS
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações do UNICENTRO |
Texto Completo: | http://tede.unicentro.br:8080/jspui/handle/jspui/694 |
Resumo: | Introduction: Alzheimer’s disease (AD) reaches 30 million people around the world. By the limited usage of the existent drugs to treat AD, that only relive the symptoms of it, several authors report the necessity of developing new compounds that are able to act in the early stages of AD, delaying it or, avoiding its appearance. Objective: Because of that, this study aims to analyze the prophylactic effect of a natural compound, (1-6)-β-D-glucan, lasiodiplodana, over an animal model of a chronic neuroinflammation. Methodology: 84 male wistar rats were allocated in 7 groups, being one receiving no treatment (CT) and the other receiving: saline (LPS-SAL and SAL-SAL) or 05, 10 and 15 mg/kg of lasiodiplodana (LPS-05mg, LPS-10mg, LPS-15mg and SAL-15mg). After 30 days of treatment, the animals received hippocamp injections of lipopolysaccharide – LPS (LPS-SAL, LPS-05mg, LPS-10mg and LPS-15mg) or saline (SAL-SAL e SAL-15mg). CT group did not pass through any surgical intervention. The locomotor/ exploratory and emotional activities were analyzed in open field and elevated plus mazes, respectively. In order to evaluate the memory of the animals, three tools were utilized: the open field maze with object recognition task, Morris water maze and the radial maze. After the behavioral tests, euthanasia was made and the brain of the rats were taken to later analyses of TBARs (thiobarbituric acid reactive substance) and nitrate/nitrite. Results: No significant difference was found in behavioral control tests among groups. In Morris water maze task, no group demonstrated significant results, but LPS-05mg group had a tendency to be different from LPS-SAL group. In the object recognition test no group showed significant results, however, LPS-10mg group had a tendency to be different from LPS-SAL group. The protocol utilized in radial maze was not efficient in evaluating the memory deficit of the rats from present study. In the analyses of TBARs and nitrate/nitrite the only group that was significantly (P<0.01) different from LPS-SAL was the one treated with 10 mg/kg of lasiodiplodana (LPS-10mg). Conclusion: It was concluded that the treatments with 05 mg/kg and 10mg/kg of lasiodiplodana were able to revert the memory deficit caused by the neuroinflammatory model, concerning associative and non-associative memories respectively, and the dosage of 10 mg/kg was capable of relieving the oxidative stress condition triggered by neuroinflammation. |
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MALFATTI, CARLOS RICARDO MANECKhttp://lattes.cnpq.br/7879558601666787083.400.019-90http://lattes.cnpq.br/2064779426980952Wouk, Jéssica2017-06-13T13:10:22Z2017-02-24Wouk, Jéssica. AVALIAÇÃO DO EFEITO PROFILÁTICO DA β-GLUCANA LASIODIPLODANA SOBRE MODELO DE NEUROINFLAMAÇÃO, DÉFICIT COGNITIVO E ESTRESSE OXIDATIVO EM RATOS. 2017. 62 f. Dissertação (Programa de Pós-Graduação em Ciências Farmacêuticas - Mestrado / Associação Ampla com UEPG) - Universidade Estadual do Centro-Oeste, Guarapuava - PR.http://tede.unicentro.br:8080/jspui/handle/jspui/694Introduction: Alzheimer’s disease (AD) reaches 30 million people around the world. By the limited usage of the existent drugs to treat AD, that only relive the symptoms of it, several authors report the necessity of developing new compounds that are able to act in the early stages of AD, delaying it or, avoiding its appearance. Objective: Because of that, this study aims to analyze the prophylactic effect of a natural compound, (1-6)-β-D-glucan, lasiodiplodana, over an animal model of a chronic neuroinflammation. Methodology: 84 male wistar rats were allocated in 7 groups, being one receiving no treatment (CT) and the other receiving: saline (LPS-SAL and SAL-SAL) or 05, 10 and 15 mg/kg of lasiodiplodana (LPS-05mg, LPS-10mg, LPS-15mg and SAL-15mg). After 30 days of treatment, the animals received hippocamp injections of lipopolysaccharide – LPS (LPS-SAL, LPS-05mg, LPS-10mg and LPS-15mg) or saline (SAL-SAL e SAL-15mg). CT group did not pass through any surgical intervention. The locomotor/ exploratory and emotional activities were analyzed in open field and elevated plus mazes, respectively. In order to evaluate the memory of the animals, three tools were utilized: the open field maze with object recognition task, Morris water maze and the radial maze. After the behavioral tests, euthanasia was made and the brain of the rats were taken to later analyses of TBARs (thiobarbituric acid reactive substance) and nitrate/nitrite. Results: No significant difference was found in behavioral control tests among groups. In Morris water maze task, no group demonstrated significant results, but LPS-05mg group had a tendency to be different from LPS-SAL group. In the object recognition test no group showed significant results, however, LPS-10mg group had a tendency to be different from LPS-SAL group. The protocol utilized in radial maze was not efficient in evaluating the memory deficit of the rats from present study. In the analyses of TBARs and nitrate/nitrite the only group that was significantly (P<0.01) different from LPS-SAL was the one treated with 10 mg/kg of lasiodiplodana (LPS-10mg). Conclusion: It was concluded that the treatments with 05 mg/kg and 10mg/kg of lasiodiplodana were able to revert the memory deficit caused by the neuroinflammatory model, concerning associative and non-associative memories respectively, and the dosage of 10 mg/kg was capable of relieving the oxidative stress condition triggered by neuroinflammation.Introdução: A doença de Alzheimer (DA) acomete atualmente certa de 30 milhões de pessoas ao redor do mundo. Pelo uso limitado dos medicamentos existentes usados para amenizar os sintomas da doença já instalada, muitos autores relatam a necessidade do desenvolvimento de novos fármacos que atuem no estágio inicial da DA, retardando-a ou, evitando o seu aparecimento. Objetivo: Por isso o presente estudo teve como objetivo analisar in vivo o efeito profilático de um composto natural e de fácil bioprodução, a (1-6-β-D-glucana) lasiodiplodana, frente a um modelo animal de neuroinflamação crônica. Metodologia: 84 ratos wistar machos foram inicialmente alocados em 7 grupos, sendo um sem tratamento (CT) e os demais tratados com: salina ( LPS-SAL e SAL-SAL) ou 05, 10 e 15 mg/kg de lasiodiplodana (LPS-05mg, LPS-10mg, LPS-15mg, SAL-15mg). Após 30 dias de tratamento, os animais receberam injeção intra hipocampal de lipopolissacarídeo – LPS (LPS-SAL, LPS-05mg, LPS-10mg, LPS-15mg) ou salina (SAL-SAL e SAL-15mg). Os animais do grupo CT não sofreram intervenção cirúrgica. Para avaliar as atividades locomotora/exploratória e emocional dos ratos foram utilizados os labirintos de campo aberto e de cruz elevado, respectivamente. Para avaliação de memória foram utilizados: o labirinto de campo aberto utilizando a tarefa de reconhecimento de objeto, o labirinto aquático de Morris e o labirinto octogonal. Após avaliação comportamental, os animais foram eutanasiados e seus encéfalos foram retirados para análises de TBARS (espécies reativas ao ácido tiobarbitúrico) e nitrato/ nitrito. Resultados: Nenhuma diferença significativa foi encontrada nas tarefas de controle comportamental entre os grupos. Na avaliação de memória no labirinto aquático de Morris nenhum grupo tratado obteve resultado estatisticamente significativo, porém houve uma tendência do grupo LPS-05mg em ser diferente do grupo LPS-SAL. Na tarefa de reconhecimento de objetos nenhum grupo tratado demonstrou resultados significativos, porém, houve uma tendência do grupo LPS-10mg em ser diferente do grupo LPS-SAL. O protocolo utilizado no labirinto octogonal não foi eficaz para avaliar a memória dos ratos do presente estudo. Nas dosagens de TBARs e nitrato/nitrito o único grupo que mostrou-se significativamente diferente (P<0,01) do grupo LPS-SAL foi o LPS-10mg. Conclusão: Conclui-se que a dose de 5 mg/kg e 10 mg/kg de lasiodiplodana pode ser capaz de reverter o quadro amnésico subsequente ao processo neuroinflamatório, no se que diz respeito a memória associativa e não associativa, respectivamente, e a dose de 10 mg/kg é capaz de amenizar o quadro de estresse oxidativo ocasionado pela neuroinflamação.Submitted by Fabiano Jucá (fjuca@unicentro.br) on 2017-06-13T13:10:22Z No. of bitstreams: 1 Jéssica Wouk.pdf: 1894257 bytes, checksum: 83a39242573bfff769aae35f7acdc645 (MD5)Made available in DSpace on 2017-06-13T13:10:22Z (GMT). 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dc.title.por.fl_str_mv |
AVALIAÇÃO DO EFEITO PROFILÁTICO DA β-GLUCANA LASIODIPLODANA SOBRE MODELO DE NEUROINFLAMAÇÃO, DÉFICIT COGNITIVO E ESTRESSE OXIDATIVO EM RATOS |
title |
AVALIAÇÃO DO EFEITO PROFILÁTICO DA β-GLUCANA LASIODIPLODANA SOBRE MODELO DE NEUROINFLAMAÇÃO, DÉFICIT COGNITIVO E ESTRESSE OXIDATIVO EM RATOS |
spellingShingle |
AVALIAÇÃO DO EFEITO PROFILÁTICO DA β-GLUCANA LASIODIPLODANA SOBRE MODELO DE NEUROINFLAMAÇÃO, DÉFICIT COGNITIVO E ESTRESSE OXIDATIVO EM RATOS Wouk, Jéssica neuroinflamação estresse oxidativo comportamento lasiodiplodana neuroinflammation oxidative stress behavior lasiodiplodana CIENCIAS DA SAUDE::FARMACIA |
title_short |
AVALIAÇÃO DO EFEITO PROFILÁTICO DA β-GLUCANA LASIODIPLODANA SOBRE MODELO DE NEUROINFLAMAÇÃO, DÉFICIT COGNITIVO E ESTRESSE OXIDATIVO EM RATOS |
title_full |
AVALIAÇÃO DO EFEITO PROFILÁTICO DA β-GLUCANA LASIODIPLODANA SOBRE MODELO DE NEUROINFLAMAÇÃO, DÉFICIT COGNITIVO E ESTRESSE OXIDATIVO EM RATOS |
title_fullStr |
AVALIAÇÃO DO EFEITO PROFILÁTICO DA β-GLUCANA LASIODIPLODANA SOBRE MODELO DE NEUROINFLAMAÇÃO, DÉFICIT COGNITIVO E ESTRESSE OXIDATIVO EM RATOS |
title_full_unstemmed |
AVALIAÇÃO DO EFEITO PROFILÁTICO DA β-GLUCANA LASIODIPLODANA SOBRE MODELO DE NEUROINFLAMAÇÃO, DÉFICIT COGNITIVO E ESTRESSE OXIDATIVO EM RATOS |
title_sort |
AVALIAÇÃO DO EFEITO PROFILÁTICO DA β-GLUCANA LASIODIPLODANA SOBRE MODELO DE NEUROINFLAMAÇÃO, DÉFICIT COGNITIVO E ESTRESSE OXIDATIVO EM RATOS |
author |
Wouk, Jéssica |
author_facet |
Wouk, Jéssica |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
MALFATTI, CARLOS RICARDO MANECK |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/7879558601666787 |
dc.contributor.authorID.fl_str_mv |
083.400.019-90 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/2064779426980952 |
dc.contributor.author.fl_str_mv |
Wouk, Jéssica |
contributor_str_mv |
MALFATTI, CARLOS RICARDO MANECK |
dc.subject.por.fl_str_mv |
neuroinflamação estresse oxidativo comportamento lasiodiplodana |
topic |
neuroinflamação estresse oxidativo comportamento lasiodiplodana neuroinflammation oxidative stress behavior lasiodiplodana CIENCIAS DA SAUDE::FARMACIA |
dc.subject.eng.fl_str_mv |
neuroinflammation oxidative stress behavior lasiodiplodana |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE::FARMACIA |
description |
Introduction: Alzheimer’s disease (AD) reaches 30 million people around the world. By the limited usage of the existent drugs to treat AD, that only relive the symptoms of it, several authors report the necessity of developing new compounds that are able to act in the early stages of AD, delaying it or, avoiding its appearance. Objective: Because of that, this study aims to analyze the prophylactic effect of a natural compound, (1-6)-β-D-glucan, lasiodiplodana, over an animal model of a chronic neuroinflammation. Methodology: 84 male wistar rats were allocated in 7 groups, being one receiving no treatment (CT) and the other receiving: saline (LPS-SAL and SAL-SAL) or 05, 10 and 15 mg/kg of lasiodiplodana (LPS-05mg, LPS-10mg, LPS-15mg and SAL-15mg). After 30 days of treatment, the animals received hippocamp injections of lipopolysaccharide – LPS (LPS-SAL, LPS-05mg, LPS-10mg and LPS-15mg) or saline (SAL-SAL e SAL-15mg). CT group did not pass through any surgical intervention. The locomotor/ exploratory and emotional activities were analyzed in open field and elevated plus mazes, respectively. In order to evaluate the memory of the animals, three tools were utilized: the open field maze with object recognition task, Morris water maze and the radial maze. After the behavioral tests, euthanasia was made and the brain of the rats were taken to later analyses of TBARs (thiobarbituric acid reactive substance) and nitrate/nitrite. Results: No significant difference was found in behavioral control tests among groups. In Morris water maze task, no group demonstrated significant results, but LPS-05mg group had a tendency to be different from LPS-SAL group. In the object recognition test no group showed significant results, however, LPS-10mg group had a tendency to be different from LPS-SAL group. The protocol utilized in radial maze was not efficient in evaluating the memory deficit of the rats from present study. In the analyses of TBARs and nitrate/nitrite the only group that was significantly (P<0.01) different from LPS-SAL was the one treated with 10 mg/kg of lasiodiplodana (LPS-10mg). Conclusion: It was concluded that the treatments with 05 mg/kg and 10mg/kg of lasiodiplodana were able to revert the memory deficit caused by the neuroinflammatory model, concerning associative and non-associative memories respectively, and the dosage of 10 mg/kg was capable of relieving the oxidative stress condition triggered by neuroinflammation. |
publishDate |
2017 |
dc.date.accessioned.fl_str_mv |
2017-06-13T13:10:22Z |
dc.date.issued.fl_str_mv |
2017-02-24 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Wouk, Jéssica. AVALIAÇÃO DO EFEITO PROFILÁTICO DA β-GLUCANA LASIODIPLODANA SOBRE MODELO DE NEUROINFLAMAÇÃO, DÉFICIT COGNITIVO E ESTRESSE OXIDATIVO EM RATOS. 2017. 62 f. Dissertação (Programa de Pós-Graduação em Ciências Farmacêuticas - Mestrado / Associação Ampla com UEPG) - Universidade Estadual do Centro-Oeste, Guarapuava - PR. |
dc.identifier.uri.fl_str_mv |
http://tede.unicentro.br:8080/jspui/handle/jspui/694 |
identifier_str_mv |
Wouk, Jéssica. AVALIAÇÃO DO EFEITO PROFILÁTICO DA β-GLUCANA LASIODIPLODANA SOBRE MODELO DE NEUROINFLAMAÇÃO, DÉFICIT COGNITIVO E ESTRESSE OXIDATIVO EM RATOS. 2017. 62 f. Dissertação (Programa de Pós-Graduação em Ciências Farmacêuticas - Mestrado / Associação Ampla com UEPG) - Universidade Estadual do Centro-Oeste, Guarapuava - PR. |
url |
http://tede.unicentro.br:8080/jspui/handle/jspui/694 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.program.fl_str_mv |
-7679163762264962259 |
dc.relation.confidence.fl_str_mv |
600 600 600 600 |
dc.relation.department.fl_str_mv |
-6934766838009717290 |
dc.relation.cnpq.fl_str_mv |
6997636413449754996 |
dc.relation.sponsorship.fl_str_mv |
2075167498588264571 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Estadual do Centro-Oeste |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Ciências Farmacêuticas (Mestrado / Associação Ampla com UEPG) |
dc.publisher.initials.fl_str_mv |
UNICENTRO |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Unicentro::Departamento de Farmácia |
publisher.none.fl_str_mv |
Universidade Estadual do Centro-Oeste |
dc.source.none.fl_str_mv |
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Universidade Estadual do Centro-Oeste (UNICENTRO) |
instacron_str |
UNICENTRO |
institution |
UNICENTRO |
reponame_str |
Biblioteca Digital de Teses e Dissertações do UNICENTRO |
collection |
Biblioteca Digital de Teses e Dissertações do UNICENTRO |
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MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações do UNICENTRO - Universidade Estadual do Centro-Oeste (UNICENTRO) |
repository.mail.fl_str_mv |
repositorio@unicentro.br||fabianoqueiroz@yahoo.com.br |
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1811733811555205120 |