p53 protein expression in corneal squamous cell carcinomas of dogs

Detalhes bibliográficos
Autor(a) principal: Cossi, Lucas Bahdour
Data de Publicação: 2015
Outros Autores: Lima, Silmara Sanae Sakamoto, Andrade, Alexandre Lima
Tipo de documento: Artigo
Idioma: por
Título da fonte: Semina. Ciências Agrárias (Online)
Texto Completo: https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/16913
Resumo: Ocular tumors play an increasing concern in veterinary ophthalmology. Corneal squamous cell carcinoma is unfrequent in dogs, and by this way it has little studies. Studies that investigated the carcinogenesis mechanisms wich could help to the development of ocular squamous cell carcinoma (SCC) in dog are rare. The aim of this work was to identify by immunohistochemical techniques, the p53 protein expression in the spontaneous dog corneal SCC. For this work, were used five cases of corneal SCC and one case of actinic keratitis. The sections were obtained from paraffin-wax blocks and submitted to histopathological and immunohistochemical analysis. All the six samples showed immunolabeling to cytokeratin and p53 protein. These results support the conclusions that the immunoreactivity of p53 protein by immunohistochemistry is present in canine corneal SCC suppporting its role in carcinogenesis of this tumor, but not provides prognostic indicators in cases of SCC corneal in dog; and can be a association of exposure to solar radiation with the possible mutation of the TP53 gene.
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spelling p53 protein expression in corneal squamous cell carcinomas of dogsExpressão da proteína p53 no carcinoma de células escamosas corneal em cãesDogCorneaImmunohistochemistryTumors.CãoCórneaImunoistoquímicaNeoplasia.Oncologia e oftalmologia veterináriaOcular tumors play an increasing concern in veterinary ophthalmology. Corneal squamous cell carcinoma is unfrequent in dogs, and by this way it has little studies. Studies that investigated the carcinogenesis mechanisms wich could help to the development of ocular squamous cell carcinoma (SCC) in dog are rare. The aim of this work was to identify by immunohistochemical techniques, the p53 protein expression in the spontaneous dog corneal SCC. For this work, were used five cases of corneal SCC and one case of actinic keratitis. The sections were obtained from paraffin-wax blocks and submitted to histopathological and immunohistochemical analysis. All the six samples showed immunolabeling to cytokeratin and p53 protein. These results support the conclusions that the immunoreactivity of p53 protein by immunohistochemistry is present in canine corneal SCC suppporting its role in carcinogenesis of this tumor, but not provides prognostic indicators in cases of SCC corneal in dog; and can be a association of exposure to solar radiation with the possible mutation of the TP53 gene.As neoplasias oculares representam uma crescente preocupação na oftalmologia veterinária. O carcinoma de células escamosas corneal é raro em cães e, por isso, pouco estudado. Pesquisas investigando os mecanismos da carcinogênese que contribuem para o desenvolvimento do carcinoma de células escamosas (CCE) ocular em cães são infrequentes. No presente trabalho teve-se por objetivo identificar, por imunoistoquímica, a expressão da proteína p53 no carcinoma de células escamosas corneal espontâneo de cães. Foram utilizados cinco casos de CCE corneal e um caso de ceratite actínica. Os cortes foram obtidos a partir dos blocos de parafina e submetidos à análise anatomopatológica e imunoistoquímica. Do total de seis amostras, todas apresentaram imunomarcação para citoqueratina e para a proteína p53. Conclui-se que a imunorreatividade da proteína p53 pela imunoistoquímica foi presente nos CCE corneal de cães contribuindo para sua carcinogênese, mas não fornece indicadores de prognóstico em casos de CCE córnea em cão; e pode existir forte relação da exposição à radiação solar com a possível mutação do gene TP53.UEL2015-06-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigoapplication/pdfhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/1691310.5433/1679-0359.2015v36n3p1385Semina: Ciências Agrárias; Vol. 36 No. 3 (2015); 1385-1396Semina: Ciências Agrárias; v. 36 n. 3 (2015); 1385-13961679-03591676-546Xreponame:Semina. Ciências Agrárias (Online)instname:Universidade Estadual de Londrina (UEL)instacron:UELporhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/16913/pdf_684Copyright (c) 2015 Semina: Ciências Agráriashttp://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessCossi, Lucas BahdourLima, Silmara Sanae SakamotoAndrade, Alexandre Lima2023-01-13T12:47:40Zoai:ojs.pkp.sfu.ca:article/16913Revistahttp://www.uel.br/revistas/uel/index.php/semagrariasPUBhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/oaisemina.agrarias@uel.br1679-03591676-546Xopendoar:2023-01-13T12:47:40Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)false
dc.title.none.fl_str_mv p53 protein expression in corneal squamous cell carcinomas of dogs
Expressão da proteína p53 no carcinoma de células escamosas corneal em cães
title p53 protein expression in corneal squamous cell carcinomas of dogs
spellingShingle p53 protein expression in corneal squamous cell carcinomas of dogs
Cossi, Lucas Bahdour
Dog
Cornea
Immunohistochemistry
Tumors.
Cão
Córnea
Imunoistoquímica
Neoplasia.
Oncologia e oftalmologia veterinária
title_short p53 protein expression in corneal squamous cell carcinomas of dogs
title_full p53 protein expression in corneal squamous cell carcinomas of dogs
title_fullStr p53 protein expression in corneal squamous cell carcinomas of dogs
title_full_unstemmed p53 protein expression in corneal squamous cell carcinomas of dogs
title_sort p53 protein expression in corneal squamous cell carcinomas of dogs
author Cossi, Lucas Bahdour
author_facet Cossi, Lucas Bahdour
Lima, Silmara Sanae Sakamoto
Andrade, Alexandre Lima
author_role author
author2 Lima, Silmara Sanae Sakamoto
Andrade, Alexandre Lima
author2_role author
author
dc.contributor.author.fl_str_mv Cossi, Lucas Bahdour
Lima, Silmara Sanae Sakamoto
Andrade, Alexandre Lima
dc.subject.por.fl_str_mv Dog
Cornea
Immunohistochemistry
Tumors.
Cão
Córnea
Imunoistoquímica
Neoplasia.
Oncologia e oftalmologia veterinária
topic Dog
Cornea
Immunohistochemistry
Tumors.
Cão
Córnea
Imunoistoquímica
Neoplasia.
Oncologia e oftalmologia veterinária
description Ocular tumors play an increasing concern in veterinary ophthalmology. Corneal squamous cell carcinoma is unfrequent in dogs, and by this way it has little studies. Studies that investigated the carcinogenesis mechanisms wich could help to the development of ocular squamous cell carcinoma (SCC) in dog are rare. The aim of this work was to identify by immunohistochemical techniques, the p53 protein expression in the spontaneous dog corneal SCC. For this work, were used five cases of corneal SCC and one case of actinic keratitis. The sections were obtained from paraffin-wax blocks and submitted to histopathological and immunohistochemical analysis. All the six samples showed immunolabeling to cytokeratin and p53 protein. These results support the conclusions that the immunoreactivity of p53 protein by immunohistochemistry is present in canine corneal SCC suppporting its role in carcinogenesis of this tumor, but not provides prognostic indicators in cases of SCC corneal in dog; and can be a association of exposure to solar radiation with the possible mutation of the TP53 gene.
publishDate 2015
dc.date.none.fl_str_mv 2015-06-10
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Artigo
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/16913
10.5433/1679-0359.2015v36n3p1385
url https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/16913
identifier_str_mv 10.5433/1679-0359.2015v36n3p1385
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/16913/pdf_684
dc.rights.driver.fl_str_mv Copyright (c) 2015 Semina: Ciências Agrárias
http://creativecommons.org/licenses/by-nc/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2015 Semina: Ciências Agrárias
http://creativecommons.org/licenses/by-nc/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv UEL
publisher.none.fl_str_mv UEL
dc.source.none.fl_str_mv Semina: Ciências Agrárias; Vol. 36 No. 3 (2015); 1385-1396
Semina: Ciências Agrárias; v. 36 n. 3 (2015); 1385-1396
1679-0359
1676-546X
reponame:Semina. Ciências Agrárias (Online)
instname:Universidade Estadual de Londrina (UEL)
instacron:UEL
instname_str Universidade Estadual de Londrina (UEL)
instacron_str UEL
institution UEL
reponame_str Semina. Ciências Agrárias (Online)
collection Semina. Ciências Agrárias (Online)
repository.name.fl_str_mv Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)
repository.mail.fl_str_mv semina.agrarias@uel.br
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