Characterization of bladder calculi and urinalysis in rabbits (Oryctolagus cuniculus) treated with mesenchymal adipose-derived stem cells (ADSCs) after partial urinary bladder allotransplantation

Detalhes bibliográficos
Autor(a) principal: Pinto Filho, Saulo Tadeu Lemos
Data de Publicação: 2016
Outros Autores: Dalmolin, Fabíola, Pinho, Renata Medina, Giglio, Camila Feltrin, Felin, Diandra Visentini, Faria, Kamila Lopes de, Vargas, Aline da Rosa, Brun, Maurício Veloso, Vaz, Marcos André Braz, Pippi, Ney Luis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Semina. Ciências Agrárias (Online)
Texto Completo: https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/21193
Resumo: Bladder calculi associated or not with early crystalluria or salt deposits can be a common finding after reconstructive bladder surgery. The objective of this study was to characterize calculi and urine of domestic rabbits treated with mesenchymal adipose-derived stem cells (ADSCs) after partial urinary bladder allotransplantation. Twenty-four New Zealand White rabbits were submitted to surgery and treated postoperatively with cyclosporine or ADSCs for immunosuppression. There were no signs of graft rejection in either treatment group 30 days after surgery. Fewer animals presented bladder calculi in the ADSC treated group (33.3%) compared to the cyclosporine treated group (58.3%). Calcium was the predominant component of calculi in both groups. Urinalysis revealed no haematuria or bacteriuria in the ADSC group, in contrast to the results obtained for the cyclosporine group. ADSCs may be an attractive alternative to cyclosporine for immunosuppression after bladder allotransplantation.
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spelling Characterization of bladder calculi and urinalysis in rabbits (Oryctolagus cuniculus) treated with mesenchymal adipose-derived stem cells (ADSCs) after partial urinary bladder allotransplantationCaracterização de cálculos vesicais e urinálise em coelhos (Oryctolagus cuniculus) submetidos a alotransplante parcial de vesícula urinária e tratados com células-tronco mesenquimais alogênicas derivadas do tecido adiposo (ADSCs)BladderSurgeryMSCUrolithiasis.BexigaCirurgiaCTMUrolitíase.Bladder calculi associated or not with early crystalluria or salt deposits can be a common finding after reconstructive bladder surgery. The objective of this study was to characterize calculi and urine of domestic rabbits treated with mesenchymal adipose-derived stem cells (ADSCs) after partial urinary bladder allotransplantation. Twenty-four New Zealand White rabbits were submitted to surgery and treated postoperatively with cyclosporine or ADSCs for immunosuppression. There were no signs of graft rejection in either treatment group 30 days after surgery. Fewer animals presented bladder calculi in the ADSC treated group (33.3%) compared to the cyclosporine treated group (58.3%). Calcium was the predominant component of calculi in both groups. Urinalysis revealed no haematuria or bacteriuria in the ADSC group, in contrast to the results obtained for the cyclosporine group. ADSCs may be an attractive alternative to cyclosporine for immunosuppression after bladder allotransplantation.A litíase vesical pode ser um achado comum quando se faz a reconstrução da bexiga, condição que pode estar associada a alterações precoces como cristalúria e presença de depósito de sais. O objetivo deste artigo é caracterizar os cálculos e a urinálise de coelhos domésticos submetidos a alotransplante de vesícula urinária e tratados com células-tronco alogênicas derivadas do tecido adiposo (ADSCs). Foram utilizados 25 coelhos Nova Zelândia Branco, os quais foram submetidos a alotransplante parcial de bexiga e tratados com ciclosporina (GCi) ou células-tronco mesenquimais (GCe) como agentes imunossupressores. Houve menor número de animais com cálculo vesical no grupo tratado com ADSCs (33.3%), sendo cálcio o mineral mais frequentemente observado; na urinálise, os animais tratados com ADSCs não demonstraram hematúria e/ou bacteriúria. As ADSCs podem ser uma alternativa à ciclosporina para imunossupressão após alotransplante de bexiga.UEL2016-04-26info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/2119310.5433/1679-0359.2016v37n2p867Semina: Ciências Agrárias; Vol. 37 No. 2 (2016); 867-876Semina: Ciências Agrárias; v. 37 n. 2 (2016); 867-8761679-03591676-546Xreponame:Semina. Ciências Agrárias (Online)instname:Universidade Estadual de Londrina (UEL)instacron:UELenghttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/21193/18628http://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessPinto Filho, Saulo Tadeu LemosDalmolin, FabíolaPinho, Renata MedinaGiglio, Camila FeltrinFelin, Diandra VisentiniFaria, Kamila Lopes deVargas, Aline da RosaBrun, Maurício VelosoVaz, Marcos André BrazPippi, Ney Luis2022-12-01T16:32:54Zoai:ojs.pkp.sfu.ca:article/21193Revistahttp://www.uel.br/revistas/uel/index.php/semagrariasPUBhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/oaisemina.agrarias@uel.br1679-03591676-546Xopendoar:2022-12-01T16:32:54Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)false
dc.title.none.fl_str_mv Characterization of bladder calculi and urinalysis in rabbits (Oryctolagus cuniculus) treated with mesenchymal adipose-derived stem cells (ADSCs) after partial urinary bladder allotransplantation
Caracterização de cálculos vesicais e urinálise em coelhos (Oryctolagus cuniculus) submetidos a alotransplante parcial de vesícula urinária e tratados com células-tronco mesenquimais alogênicas derivadas do tecido adiposo (ADSCs)
title Characterization of bladder calculi and urinalysis in rabbits (Oryctolagus cuniculus) treated with mesenchymal adipose-derived stem cells (ADSCs) after partial urinary bladder allotransplantation
spellingShingle Characterization of bladder calculi and urinalysis in rabbits (Oryctolagus cuniculus) treated with mesenchymal adipose-derived stem cells (ADSCs) after partial urinary bladder allotransplantation
Pinto Filho, Saulo Tadeu Lemos
Bladder
Surgery
MSC
Urolithiasis.
Bexiga
Cirurgia
CTM
Urolitíase.
title_short Characterization of bladder calculi and urinalysis in rabbits (Oryctolagus cuniculus) treated with mesenchymal adipose-derived stem cells (ADSCs) after partial urinary bladder allotransplantation
title_full Characterization of bladder calculi and urinalysis in rabbits (Oryctolagus cuniculus) treated with mesenchymal adipose-derived stem cells (ADSCs) after partial urinary bladder allotransplantation
title_fullStr Characterization of bladder calculi and urinalysis in rabbits (Oryctolagus cuniculus) treated with mesenchymal adipose-derived stem cells (ADSCs) after partial urinary bladder allotransplantation
title_full_unstemmed Characterization of bladder calculi and urinalysis in rabbits (Oryctolagus cuniculus) treated with mesenchymal adipose-derived stem cells (ADSCs) after partial urinary bladder allotransplantation
title_sort Characterization of bladder calculi and urinalysis in rabbits (Oryctolagus cuniculus) treated with mesenchymal adipose-derived stem cells (ADSCs) after partial urinary bladder allotransplantation
author Pinto Filho, Saulo Tadeu Lemos
author_facet Pinto Filho, Saulo Tadeu Lemos
Dalmolin, Fabíola
Pinho, Renata Medina
Giglio, Camila Feltrin
Felin, Diandra Visentini
Faria, Kamila Lopes de
Vargas, Aline da Rosa
Brun, Maurício Veloso
Vaz, Marcos André Braz
Pippi, Ney Luis
author_role author
author2 Dalmolin, Fabíola
Pinho, Renata Medina
Giglio, Camila Feltrin
Felin, Diandra Visentini
Faria, Kamila Lopes de
Vargas, Aline da Rosa
Brun, Maurício Veloso
Vaz, Marcos André Braz
Pippi, Ney Luis
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pinto Filho, Saulo Tadeu Lemos
Dalmolin, Fabíola
Pinho, Renata Medina
Giglio, Camila Feltrin
Felin, Diandra Visentini
Faria, Kamila Lopes de
Vargas, Aline da Rosa
Brun, Maurício Veloso
Vaz, Marcos André Braz
Pippi, Ney Luis
dc.subject.por.fl_str_mv Bladder
Surgery
MSC
Urolithiasis.
Bexiga
Cirurgia
CTM
Urolitíase.
topic Bladder
Surgery
MSC
Urolithiasis.
Bexiga
Cirurgia
CTM
Urolitíase.
description Bladder calculi associated or not with early crystalluria or salt deposits can be a common finding after reconstructive bladder surgery. The objective of this study was to characterize calculi and urine of domestic rabbits treated with mesenchymal adipose-derived stem cells (ADSCs) after partial urinary bladder allotransplantation. Twenty-four New Zealand White rabbits were submitted to surgery and treated postoperatively with cyclosporine or ADSCs for immunosuppression. There were no signs of graft rejection in either treatment group 30 days after surgery. Fewer animals presented bladder calculi in the ADSC treated group (33.3%) compared to the cyclosporine treated group (58.3%). Calcium was the predominant component of calculi in both groups. Urinalysis revealed no haematuria or bacteriuria in the ADSC group, in contrast to the results obtained for the cyclosporine group. ADSCs may be an attractive alternative to cyclosporine for immunosuppression after bladder allotransplantation.
publishDate 2016
dc.date.none.fl_str_mv 2016-04-26
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/21193
10.5433/1679-0359.2016v37n2p867
url https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/21193
identifier_str_mv 10.5433/1679-0359.2016v37n2p867
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/21193/18628
dc.rights.driver.fl_str_mv http://creativecommons.org/licenses/by-nc/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv UEL
publisher.none.fl_str_mv UEL
dc.source.none.fl_str_mv Semina: Ciências Agrárias; Vol. 37 No. 2 (2016); 867-876
Semina: Ciências Agrárias; v. 37 n. 2 (2016); 867-876
1679-0359
1676-546X
reponame:Semina. Ciências Agrárias (Online)
instname:Universidade Estadual de Londrina (UEL)
instacron:UEL
instname_str Universidade Estadual de Londrina (UEL)
instacron_str UEL
institution UEL
reponame_str Semina. Ciências Agrárias (Online)
collection Semina. Ciências Agrárias (Online)
repository.name.fl_str_mv Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)
repository.mail.fl_str_mv semina.agrarias@uel.br
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