Clinical evaluation of postoperative analgesia provided by ketoprofen associated with intravenous or epidural morphine in bitches undergoing ovariosalpingohysterectomy
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Semina. Ciências Agrárias (Online) |
Texto Completo: | https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/16505 |
Resumo: | Multimodal analgesia refers to the practice of combining multiple analgesic drug classes or techniques to target different points along the pain pathway. The objective of this work was to evaluate clinically if ketoprofen associated or not with intravenous or epidural morphine provided adequate postoperative analgesia in bitches undergoing ovariosalpingohysterectomy (OSH). Forty healthy female dogs, weighing 10.7±6.0 kg, sedated with acepromazine (0.05mg kg –1.iv), induced with propofol (5 mg.kg-1. iv) and maintained with isoflurane anesthesia, were distributed into four groups of 10 animals each. After stabilization of inhalation anesthesia, the bitches in Miv and CMiv groups received 0.2 mg.kg-1 of morphine intravenously diluted in 10ml of saline; whereas Mep and CMep groups received 0.1mg.kg-1 of epidural morphine. Thirty minutes after premedication, 2.0mg.kg-1.im of ketoprofen was administered in groups CMiv and CMep. Heart and respiratory rate, systolic blood pressure, and rectal temperature were measured. The degree of analgesia was assessed by a blind study in the following 6 hours after surgery, using a descriptive scale and a scale composed by physiologic and behavioral parameters. An statistical analysis was performed using the Tukey-Kramer test and nonparametric Kruskal-Wallis test, with statistical significance of 5%. There was no important difference between the four groups regarding postoperative analgesia, heart and respiratory rate, systolic blood pressure and rectal temperature. According to the results it can be concluded that the use of ketoprofen associated with intravenous or epidural morphine provided adequate and safe analgesia in the first six hours of postoperative in bitches undergoing ovariohysterectomy, suggesting that there was no analgesic potentiation when both agents were combined. |
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Semina. Ciências Agrárias (Online) |
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Clinical evaluation of postoperative analgesia provided by ketoprofen associated with intravenous or epidural morphine in bitches undergoing ovariosalpingohysterectomyAvaliação clínica da analgesia pós-operatória proporcionada pelo cetoprofeno associado à morfina pela via intravenosa ou epidural em cadelas submetidas à ovariosalpingohisterectomiaOpioidsNSAIDPainDogs.Anestesiologia VeterináriaOpióidesAINEDorCães.Anestesiologia AnimalMultimodal analgesia refers to the practice of combining multiple analgesic drug classes or techniques to target different points along the pain pathway. The objective of this work was to evaluate clinically if ketoprofen associated or not with intravenous or epidural morphine provided adequate postoperative analgesia in bitches undergoing ovariosalpingohysterectomy (OSH). Forty healthy female dogs, weighing 10.7±6.0 kg, sedated with acepromazine (0.05mg kg –1.iv), induced with propofol (5 mg.kg-1. iv) and maintained with isoflurane anesthesia, were distributed into four groups of 10 animals each. After stabilization of inhalation anesthesia, the bitches in Miv and CMiv groups received 0.2 mg.kg-1 of morphine intravenously diluted in 10ml of saline; whereas Mep and CMep groups received 0.1mg.kg-1 of epidural morphine. Thirty minutes after premedication, 2.0mg.kg-1.im of ketoprofen was administered in groups CMiv and CMep. Heart and respiratory rate, systolic blood pressure, and rectal temperature were measured. The degree of analgesia was assessed by a blind study in the following 6 hours after surgery, using a descriptive scale and a scale composed by physiologic and behavioral parameters. An statistical analysis was performed using the Tukey-Kramer test and nonparametric Kruskal-Wallis test, with statistical significance of 5%. There was no important difference between the four groups regarding postoperative analgesia, heart and respiratory rate, systolic blood pressure and rectal temperature. According to the results it can be concluded that the use of ketoprofen associated with intravenous or epidural morphine provided adequate and safe analgesia in the first six hours of postoperative in bitches undergoing ovariohysterectomy, suggesting that there was no analgesic potentiation when both agents were combined.A analgesia multimodal refere-se à prática de associar várias classes de analgésicos ou técnicas para atuar em diferentes pontos ao longo da via da dor. Objetivou-se avaliar clinicamente a qualidade da analgesia pós-operatória promovida pelo cetoprofeno, associado ou não à morfina pela via intravenosa ou epidural, em cadelas submetidas à ovariosalpingohisterectomia (OSH). Quarenta cadelas hígidas, pesando 10,7±6,0kg, tranquilizadas com acepromazina (0,05mg.kg-1.iv), induzidas com propofol (5mg. kg-1.iv) e mantidas sob anestesia inalatória com isoflurano, foram distribuídas em quatro grupos de 10 animais cada. Em Miv e CMiv as cadelas receberam após estabilização da anestesia inalatória, 0,2mg. kg-1 de morfina pela via intravenosa, diluídos em 10ml de salina; enquanto que os animais de Mep e CMep receberam 0,1mg.kg-1 de morfina pela via epidural. O cetoprofeno foi administrado na dose 2,0mg.kg-1.im, nos grupos CMiv e CMep, 30 minutos após a medicação pré-anestésica. Mensuraram-se as frequências cardíaca (FC) e respiratória (f), pressão arterial sistólica (PAS), e temperatura retal (T). O grau de analgesia foi avaliado pelo método cego nas primeiras seis horas após a cirurgia, através de escalas de dor descritivas e escalas compostas por parâmetros fisiológicos e comportamentais. A estatística foi realizada mediante teste de Tukey-Kramer e análise não paramétrica de Kruskal-Wallis, com nível de significância de 5%. Não houve diferença estatística entre os quatro grupos estudados, em relação à analgesia pós-operatória, FC, f, PAS e T. De acordo com os resultados obtidos, pode-se concluir que o emprego do cetoprofeno, associado à morfina pela via intravenosa ou epidural proporcionou analgesia adequada e segura nas primeiras seis horas de analgesia pós-operatória em cadelas submetidas à OSH, sugerindo não haver potencialização analgésica quando da associação de ambos os agentes.UEL2015-04-22info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de Literaturaapplication/pdfhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/1650510.5433/1679-0359.2015v36n2p817Semina: Ciências Agrárias; Vol. 36 No. 2 (2015); 817-826Semina: Ciências Agrárias; v. 36 n. 2 (2015); 817-8261679-03591676-546Xreponame:Semina. Ciências Agrárias (Online)instname:Universidade Estadual de Londrina (UEL)instacron:UELporhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/16505/pdf_633Copyright (c) 2015 Semina: Ciências Agráriashttp://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessSantos, Gabriela Carvalho AquilinoClark, Rosana Maria de OliveiraSaid, Roueda AbouRamos, Christhiano Midlej SilvaMunhoz, Alexandre Dias2023-01-13T14:00:56Zoai:ojs.pkp.sfu.ca:article/16505Revistahttp://www.uel.br/revistas/uel/index.php/semagrariasPUBhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/oaisemina.agrarias@uel.br1679-03591676-546Xopendoar:2023-01-13T14:00:56Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)false |
dc.title.none.fl_str_mv |
Clinical evaluation of postoperative analgesia provided by ketoprofen associated with intravenous or epidural morphine in bitches undergoing ovariosalpingohysterectomy Avaliação clínica da analgesia pós-operatória proporcionada pelo cetoprofeno associado à morfina pela via intravenosa ou epidural em cadelas submetidas à ovariosalpingohisterectomia |
title |
Clinical evaluation of postoperative analgesia provided by ketoprofen associated with intravenous or epidural morphine in bitches undergoing ovariosalpingohysterectomy |
spellingShingle |
Clinical evaluation of postoperative analgesia provided by ketoprofen associated with intravenous or epidural morphine in bitches undergoing ovariosalpingohysterectomy Santos, Gabriela Carvalho Aquilino Opioids NSAID Pain Dogs. Anestesiologia Veterinária Opióides AINE Dor Cães. Anestesiologia Animal |
title_short |
Clinical evaluation of postoperative analgesia provided by ketoprofen associated with intravenous or epidural morphine in bitches undergoing ovariosalpingohysterectomy |
title_full |
Clinical evaluation of postoperative analgesia provided by ketoprofen associated with intravenous or epidural morphine in bitches undergoing ovariosalpingohysterectomy |
title_fullStr |
Clinical evaluation of postoperative analgesia provided by ketoprofen associated with intravenous or epidural morphine in bitches undergoing ovariosalpingohysterectomy |
title_full_unstemmed |
Clinical evaluation of postoperative analgesia provided by ketoprofen associated with intravenous or epidural morphine in bitches undergoing ovariosalpingohysterectomy |
title_sort |
Clinical evaluation of postoperative analgesia provided by ketoprofen associated with intravenous or epidural morphine in bitches undergoing ovariosalpingohysterectomy |
author |
Santos, Gabriela Carvalho Aquilino |
author_facet |
Santos, Gabriela Carvalho Aquilino Clark, Rosana Maria de Oliveira Said, Roueda Abou Ramos, Christhiano Midlej Silva Munhoz, Alexandre Dias |
author_role |
author |
author2 |
Clark, Rosana Maria de Oliveira Said, Roueda Abou Ramos, Christhiano Midlej Silva Munhoz, Alexandre Dias |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Santos, Gabriela Carvalho Aquilino Clark, Rosana Maria de Oliveira Said, Roueda Abou Ramos, Christhiano Midlej Silva Munhoz, Alexandre Dias |
dc.subject.por.fl_str_mv |
Opioids NSAID Pain Dogs. Anestesiologia Veterinária Opióides AINE Dor Cães. Anestesiologia Animal |
topic |
Opioids NSAID Pain Dogs. Anestesiologia Veterinária Opióides AINE Dor Cães. Anestesiologia Animal |
description |
Multimodal analgesia refers to the practice of combining multiple analgesic drug classes or techniques to target different points along the pain pathway. The objective of this work was to evaluate clinically if ketoprofen associated or not with intravenous or epidural morphine provided adequate postoperative analgesia in bitches undergoing ovariosalpingohysterectomy (OSH). Forty healthy female dogs, weighing 10.7±6.0 kg, sedated with acepromazine (0.05mg kg –1.iv), induced with propofol (5 mg.kg-1. iv) and maintained with isoflurane anesthesia, were distributed into four groups of 10 animals each. After stabilization of inhalation anesthesia, the bitches in Miv and CMiv groups received 0.2 mg.kg-1 of morphine intravenously diluted in 10ml of saline; whereas Mep and CMep groups received 0.1mg.kg-1 of epidural morphine. Thirty minutes after premedication, 2.0mg.kg-1.im of ketoprofen was administered in groups CMiv and CMep. Heart and respiratory rate, systolic blood pressure, and rectal temperature were measured. The degree of analgesia was assessed by a blind study in the following 6 hours after surgery, using a descriptive scale and a scale composed by physiologic and behavioral parameters. An statistical analysis was performed using the Tukey-Kramer test and nonparametric Kruskal-Wallis test, with statistical significance of 5%. There was no important difference between the four groups regarding postoperative analgesia, heart and respiratory rate, systolic blood pressure and rectal temperature. According to the results it can be concluded that the use of ketoprofen associated with intravenous or epidural morphine provided adequate and safe analgesia in the first six hours of postoperative in bitches undergoing ovariohysterectomy, suggesting that there was no analgesic potentiation when both agents were combined. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-04-22 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Revisão de Literatura |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/16505 10.5433/1679-0359.2015v36n2p817 |
url |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/16505 |
identifier_str_mv |
10.5433/1679-0359.2015v36n2p817 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/16505/pdf_633 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2015 Semina: Ciências Agrárias http://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2015 Semina: Ciências Agrárias http://creativecommons.org/licenses/by-nc/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
UEL |
publisher.none.fl_str_mv |
UEL |
dc.source.none.fl_str_mv |
Semina: Ciências Agrárias; Vol. 36 No. 2 (2015); 817-826 Semina: Ciências Agrárias; v. 36 n. 2 (2015); 817-826 1679-0359 1676-546X reponame:Semina. Ciências Agrárias (Online) instname:Universidade Estadual de Londrina (UEL) instacron:UEL |
instname_str |
Universidade Estadual de Londrina (UEL) |
instacron_str |
UEL |
institution |
UEL |
reponame_str |
Semina. Ciências Agrárias (Online) |
collection |
Semina. Ciências Agrárias (Online) |
repository.name.fl_str_mv |
Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL) |
repository.mail.fl_str_mv |
semina.agrarias@uel.br |
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1799306070919741440 |