Non-steroidal anti-inflammatory drugs and kidney problems

Detalhes bibliográficos
Autor(a) principal: Santos, Ellen Juliana da Silva
Data de Publicação: 2021
Outros Autores: Silva Filho, Severino Mariano da, Guedes, João Paulo
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/22923
Resumo: The inflammatory process is a response of the immune system to some harmful stimulus that can be transmitted by physical, chemical, microbiological trauma or even complete the for, that is, it can be generated by bacteria, viruses, fungi and by some external factors such as heat or physical trauma. NSAIDs are non-steroidal anti-inflammatory drugs that have three functions: Anti-inflammatory, analgesic and anti-thermal, the mechanism of action of this class consists of inhibiting the arachidonic acid cascade, a two-way substrate: the Lipoxygenase (LOX) pathway and the life of Cyclooxygenase (COX). When arachidonic acid is converted by COX, it produces as prostaglandins and thromboxane, inhibiting as cyclooxygenases I and II and thus initiating the recurrent symptoms of inflammation. Cycoxygenase I has a constitutive function and is present in the gastric and renal mucosa, in the kidneys, it contributes to physiological functions, with a vasodilator effect, acts on the nervous system and on the renin-angiotensin-aldosterone system, regulating the blood flow in the blood flow. NSAIDs inhibit the COX enzyme, which can result in several acute or chronic kidney damage, in chronic use the risk increases in several nephrotoxicities.
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spelling Non-steroidal anti-inflammatory drugs and kidney problemsAntiinflamatorios no esteroideos y problemas renalesAnti-inflamatórios não esteroides e problemas renaisAINEEnjuagarCiclooxigenasa.NSAIDRinse offCyclooxygenase.AINERinsCiclooxigenase.The inflammatory process is a response of the immune system to some harmful stimulus that can be transmitted by physical, chemical, microbiological trauma or even complete the for, that is, it can be generated by bacteria, viruses, fungi and by some external factors such as heat or physical trauma. NSAIDs are non-steroidal anti-inflammatory drugs that have three functions: Anti-inflammatory, analgesic and anti-thermal, the mechanism of action of this class consists of inhibiting the arachidonic acid cascade, a two-way substrate: the Lipoxygenase (LOX) pathway and the life of Cyclooxygenase (COX). When arachidonic acid is converted by COX, it produces as prostaglandins and thromboxane, inhibiting as cyclooxygenases I and II and thus initiating the recurrent symptoms of inflammation. Cycoxygenase I has a constitutive function and is present in the gastric and renal mucosa, in the kidneys, it contributes to physiological functions, with a vasodilator effect, acts on the nervous system and on the renin-angiotensin-aldosterone system, regulating the blood flow in the blood flow. NSAIDs inhibit the COX enzyme, which can result in several acute or chronic kidney damage, in chronic use the risk increases in several nephrotoxicities.El proceso inflamatorio es una respuesta del sistema inmunológico a algún estímulo dañino que puede ser transmitido por trauma físico, químico, microbiológico o incluso completo, es decir, puede ser generado por bacterias, virus, hongos y por algunos factores externos como como calor o trauma físico. Los AINE son fármacos antiinflamatorios no esteroideos que tienen tres funciones: Antiinflamatorio, analgésico y anti-térmico, el mecanismo de acción de esta clase consiste en inhibir la cascada del ácido araquidónico, un sustrato bidireccional: la Lipoxigenasa (LOX) vía y la vida de la ciclooxigenasa (COX). Cuando el ácido araquidónico es convertido por COX, se produce como prostaglandinas y tromboxano, inhibiendo como ciclooxigenasas I y II e iniciando así los síntomas recurrentes de inflamación. La Cicoxigenasa I tiene una función constitutiva y está presente en la mucosa gástrica y renal, en los riñones, contribuye a las funciones fisiológicas, con efecto vasodilatador, actúa sobre el sistema nervioso y sobre el sistema renina-angiotensina-aldosterona, regulando el flujo sanguíneo en el flujo sanguíneo. Los AINE inhiben la enzima COX, lo que puede provocar varios daños renales agudos o crónicos; en el uso crónico, el riesgo aumenta en varias nefrotoxicidades.O processo inflamátorio é uma resposta do sistema imunológico a algum estímulo nocivo que pode ser causado por traumas físicos, químicos, microbiológicos ou até lesões a anticorpos, ou seja ele pode ser gerado por bactérias, vírus, fungos e por alguns fatores externos como calor ou trauma físico. Os AINEs são anti-inflamatórios não esteroides que possuem três funções:Anti-inflamatória,analgésica e anti-térmica,o mecanismo de ação desta classe consiste na inibição da cascata do ácido araquidônico ,substrato de duas vias: a via da Lipoxigenase (LOX) e a vida da Ciclooxigenase (COX). Quando o ácido araquidônico é convertido pela COX, ele produz as prostaglandinas e tromboxano, inibindo as ciclooxigenases I e II e assim,dando inicio aos sintomas recorrentes da inflamação .A cicoxigenase I possui função constitutiva e está presente na mucosa gástrica e renal, nos rins ela contribui com funçóes fisiológicas,com efeito vasoditador, atua no sistema nervoso e no sistema renina-angiotensina-aldosterona ,regulando o fluxo sanguíneo no órgão. Os AINEs inibem a enzima COX, podendo resultar em diversos danos renais agudos o crônicos, no uso crônico o risco aumenta em diversas nefrotoxicidades.Research, Society and Development2021-11-19info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2292310.33448/rsd-v10i15.22923Research, Society and Development; Vol. 10 No. 15; e301101522923Research, Society and Development; Vol. 10 Núm. 15; e301101522923Research, Society and Development; v. 10 n. 15; e3011015229232525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/22923/20044Copyright (c) 2021 Ellen Juliana da Silva Santos; Severino Mariano da Silva Filho; João Paulo Guedeshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSantos, Ellen Juliana da Silva Silva Filho, Severino Mariano da Guedes, João Paulo 2021-12-06T10:13:53Zoai:ojs.pkp.sfu.ca:article/22923Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:41:56.896870Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Non-steroidal anti-inflammatory drugs and kidney problems
Antiinflamatorios no esteroideos y problemas renales
Anti-inflamatórios não esteroides e problemas renais
title Non-steroidal anti-inflammatory drugs and kidney problems
spellingShingle Non-steroidal anti-inflammatory drugs and kidney problems
Santos, Ellen Juliana da Silva
AINE
Enjuagar
Ciclooxigenasa.
NSAID
Rinse off
Cyclooxygenase.
AINE
Rins
Ciclooxigenase.
title_short Non-steroidal anti-inflammatory drugs and kidney problems
title_full Non-steroidal anti-inflammatory drugs and kidney problems
title_fullStr Non-steroidal anti-inflammatory drugs and kidney problems
title_full_unstemmed Non-steroidal anti-inflammatory drugs and kidney problems
title_sort Non-steroidal anti-inflammatory drugs and kidney problems
author Santos, Ellen Juliana da Silva
author_facet Santos, Ellen Juliana da Silva
Silva Filho, Severino Mariano da
Guedes, João Paulo
author_role author
author2 Silva Filho, Severino Mariano da
Guedes, João Paulo
author2_role author
author
dc.contributor.author.fl_str_mv Santos, Ellen Juliana da Silva
Silva Filho, Severino Mariano da
Guedes, João Paulo
dc.subject.por.fl_str_mv AINE
Enjuagar
Ciclooxigenasa.
NSAID
Rinse off
Cyclooxygenase.
AINE
Rins
Ciclooxigenase.
topic AINE
Enjuagar
Ciclooxigenasa.
NSAID
Rinse off
Cyclooxygenase.
AINE
Rins
Ciclooxigenase.
description The inflammatory process is a response of the immune system to some harmful stimulus that can be transmitted by physical, chemical, microbiological trauma or even complete the for, that is, it can be generated by bacteria, viruses, fungi and by some external factors such as heat or physical trauma. NSAIDs are non-steroidal anti-inflammatory drugs that have three functions: Anti-inflammatory, analgesic and anti-thermal, the mechanism of action of this class consists of inhibiting the arachidonic acid cascade, a two-way substrate: the Lipoxygenase (LOX) pathway and the life of Cyclooxygenase (COX). When arachidonic acid is converted by COX, it produces as prostaglandins and thromboxane, inhibiting as cyclooxygenases I and II and thus initiating the recurrent symptoms of inflammation. Cycoxygenase I has a constitutive function and is present in the gastric and renal mucosa, in the kidneys, it contributes to physiological functions, with a vasodilator effect, acts on the nervous system and on the renin-angiotensin-aldosterone system, regulating the blood flow in the blood flow. NSAIDs inhibit the COX enzyme, which can result in several acute or chronic kidney damage, in chronic use the risk increases in several nephrotoxicities.
publishDate 2021
dc.date.none.fl_str_mv 2021-11-19
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/22923
10.33448/rsd-v10i15.22923
url https://rsdjournal.org/index.php/rsd/article/view/22923
identifier_str_mv 10.33448/rsd-v10i15.22923
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/22923/20044
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 15; e301101522923
Research, Society and Development; Vol. 10 Núm. 15; e301101522923
Research, Society and Development; v. 10 n. 15; e301101522923
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
_version_ 1797052819485753344

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